Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Insight into the properties of polymeric matrices containig active pharmaceutical ingredients obtained by means of 3D printing

2018/31/B/ST8/01327

Keywords:

3D printing hot-melt extrusion drug-polymer composites physical stability rheology

Descriptors:

  • ST8_8: Mechanics of solids
  • ST8_9: Industrial design, product and device design, ergonomics, human-machine interaction
  • ST8_1: Chemical engineering, technical chemistry, environmental engineering, sanitary engineering, engineering of chemical processes

Panel:

ST8 - Production and processes engineering: modelling, product design, process design and control, construction methods and engineering, power units and systems

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Jachowicz 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 768 800 PLN

Project start date (Y-m-d): 2019-09-03

Project end date (Y-m-d): 2023-03-02

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. Inhibition of celecoxib crystallization by mesoporous silica – Molecular dynamics studies leading to the discovery of the stabilization origin
    Authors:
    Daniel Kramarczyk, Justyna Knapik-Kowalczuk, Wojciech Smolka, Maria Ferreira Monteiro, Lidia Tajber, Marian Paluch
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2022, tom: 171, strony: 10), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ejps.2022.106132 - link to the publication
  2. Rheo-dielectric studies of the kinetics of shear-induced nematic alignment changes in itraconazole
    Authors:
    Knapik-Kowalczuk Justyna, Jurkiewicz Karolina, Kocot Antoni, Paluch Marian
    Academic press:
    JOURNAL OF MOLECULAR LIQUIDS (rok: 2020, tom: 302, strony: 6), Wydawca: ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.112494 - link to the publication
  3. Submerged Eutectic-Assisted, Solvent-Free Mechanochemical Formation of a Propranolol Salt and Its Other Multicomponent Solids
    Authors:
    Klaudia Bialek, Żaneta Wojnarowska, Marcin Skotnicki, Brendan Twamley, Marian Paluch, Lidia Tajber
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 20), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13122125 - link to the publication
  4. Druk 3D metodą osadzania termoplastycznego tworzywa jako metoda wytwarzania leków personalizowanych
    Authors:
    Jolanta Pyteraf, Witold Jamróz, Mateusz Kurek, Renata Jachowicz
    Academic press:
    Farmacja Polska (rok: 2022, tom: 78, strony: 9), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    10.32383/farmpol/163605 - link to the publication
  5. How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?
    Authors:
    Jolanta Pyteraf, Witold Jamróz, Mateusz Kurek , Joanna Szafraniec-Szczęsny, Daniel Kramarczyk, Karolina Jurkiewicz, Justyna Knapik-Kowalczuk, Jacek Tarasiuk, Sebastian Wroński, Marian Paluch, Renata Jachowicz
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 22), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/molecules26113106 - link to the publication
  6. Preparation and advanced characterization of highly drug-loaded, 3D printed orodispersible tablets containing fluconazole
    Authors:
    Jolanta Pyteraf, Witold Jamróz, Mateusz Kurek, Urszula Bąk, Jan Loskot, Daniel Kramarczyk, Marian Paluch, Renata Jachowicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2023, tom: 630, strony: 12), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2022.122444 - link to the publication
  7. Application and Multi-Stage Optimization of Daylight Polymer 3D Printing of Personalized Medicine Products
    Authors:
    Jolanta Pyteraf, Adam Pacławski, Witold Jamróz, Aleksander Mendyk, Marian Paluch, Renata Jachowicz
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14, strony: 20), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14040843 - link to the publication
  8. Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets
    Authors:
    Thao Tranová, Jolanta Pyteraf, Mateusz Kurek, Witold Jamróz, Witold Brniak, Dita Spálovska, Jan Loskot, Karolina Jurkiewicz, Joanna Grelska, Daniel Kramarczyk, Jitka Mužíková, Marian Paluch, Renata Jachowicz
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 21), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ph15010069 - link to the publication
  9. Speed it up, slow it down...An issue of bicalutamide release from 3D printed tablets
    Authors:
    Jamróz Witold, Kurek Mateusz, Szafraniec-Szczęsny Joanna, Czech Anna, Gawlak Karolina, Knapik-Kowalczuk Justyna, Leszczynski Bartosz, Wróbel Andrzej, Paluch Marian, Jachowicz Renata
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2020, tom: 143, strony: 9), Wydawca: ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
    Status:
    Published
    DOI:
    10.1016/j.ejps.2019.105169 - link to the publication
  10. Effect of shear strain on the supercooled itraconazole
    Authors:
    Justyna Knapik-Kowalczuk , Daniel Kramarczyk , Renata Jachowicz , Marian Paluch
    Academic press:
    Journal of Pharmaceutical Sciences (rok: 2023, tom: 112, strony: 8), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.xphs.2023.01.020 - link to the publication
  11. Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of Polymers
    Authors:
    Daniel Kramarczyk, Justyna Knapik-Kowalczuk, Mateusz Kurek, Witold Jamróz, Renata Jachowicz, Marian Paluch
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 22), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15030799 - link to the publication
  12. Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug-Itraconazole
    Authors:
    Jamróz Witold, Pyteraf Jolanta, Kurek Mateusz, Knapik-Kowalczuk Justyna, Szafraniec-Szczęsny Joanna, Jurkiewicz Karolina, Leszczynski Bartosz, Wróbel Andrzej, Paluch Marian, Jachowicz Renata
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 20), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/ma13214961 - link to the publication

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