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Molecular Characterization of large tRNA modification Complexes

2018/31/B/NZ1/03559

Keywords

Descriptors

  • NZ1_4: Biologia strukturalna
  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Sebastian Glatt

Number of co-investigators in the project: 5

Call

OPUS 16 – announced on 2018-09-14

Amount awarded
1 990 000 PLN
Project start date
2019-07-24
Project end date
2023-07-23
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Duży inkubator z wytrząsaniem dla kultur drożdży. Cost: 70 000 PLN
  2. Dyski Seagate – 6 szt..
  3. Dyski zewnętrzne 3 szt..
  4. Narzędzia EM. Cost: 30 000 PLN
  5. Specjalistyczny komputer.

Information in the final report

Publication in academic press/journals (7)

  1. E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation

    Authors:
    Ravichandran KE, Kaduhr L, Skupien‐Rabian B, Shvetsova E, Sokołowski M, Krutyhołowa RC, Kwasna D, Brachmann C, Lin S, Guzman Perez S, Wilk P, Kösters M, Grudnik P, Jankowska U, Leidel SA, Schaffrath R, Glatt S
    Academic press:
    The EMBO Journal (year: 2022, volume: 41(20), pages: e111318), Publisher: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.15252/embj.2022111318 – link to the publication

  2. Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops

    Authors:
    Krutyhołowa R, Reinhardt-Tews A, Chramiec-Głąbik A, Breunig KD, Glatt S
    Academic press:
    Current Genetics (year: 2020, volume: 66, pages: 823-833), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00294-020-01070-2 – link to the publication

  3. Molecular basis for the bifunctional Uba4–Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation

    Authors:
    Pabis M, Termathe M, Ravichandran KE, Kienast SD, Krutyhołowa R, Sokołowski M, Jankowska U, Grudnik P, Leidel SA and Glatt S
    Academic press:
    EMBO Journal (year: 2020, volume: 39, pages: e105087), Publisher: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.15252/embj.2020105087 – link to the publication

  4. How Elongator Acetylates tRNA Bases

    Authors:
    Abbassi NE, Biela A, Glatt S and Lin TY
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 46035), Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21218209 – link to the publication

  5. A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype

    Authors:
    1.Kojic M, Abbassi NEH, Lin TY, Jones A, Wakeling EL, Clement E, Nakou V, Singleton M, Dobosz D, Kaliakatsos M, Glatt S and Wainwright BJ
    Academic press:
    Journal of Human Genetics (year: 2023, volume: 2, pages: Online ahead of print), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s10038-023-01135-3 – link to the publication

  6. Cryo‐EM structure of the fully assembled Elongator complex

    Authors:
    Jaciuk M, Scherf D, Kaszuba K, Gaik M, Rau A, Koscielniak A, Krutyhołowa R, Rawski M, Indyka P, Graziadei A, Chramiec‐Głąbik A, Biela A, Dobosz D, Lin TY, Abbassi N, Hammermeister A, Rappsilber J, Kosinski J, Schaffrath R and Glatt S
    Academic press:
    Nucleic Acids Research (year: 2023, volume: gkac1232, pages: online ahead of print.), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1232 – link to the publication

  7. A double role of the Gal80 N-terminus in activation of transcription by Gal4p

    Authors:
    Reinhardt-Tews A, Krutyhołowa R, Günzel C, Roehl C, Glatt S* and Breunig KD
    Academic press:
    Life Science Alliance (year: 2020, volume: 3, pages: e202000665), Publisher: Rockefeller University Press
    Status:
    Published
    DOI:
    10.26508/LSA.202000665 – link to the publication

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