Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular Characterization of large tRNA modification Complexes

2018/31/B/NZ1/03559

Keywords:

Elongator tRNA modification Cryo-EM neurodegenerative diseases cancer

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sebastian Glatt 

Number of co-investigators in the project: 5

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 990 000 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2023-07-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Specjalistyczny komputer.
  2. Duży inkubator z wytrząsaniem dla kultur drożdży (70 000 PLN)
  3. Dyski zewnętrzne 3 szt..
  4. Narzędzia EM (30 000 PLN)
  5. Dyski Seagate – 6 szt..

Information in the final report

  • Publication in academic press/journals (7)
  1. A double role of the Gal80 N-terminus in activation of transcription by Gal4p
    Authors:
    Reinhardt-Tews A, Krutyhołowa R, Günzel C, Roehl C, Glatt S* and Breunig KD
    Academic press:
    Life Science Alliance (rok: 2020, tom: 3, strony: e202000665), Wydawca: Rockefeller University Press
    Status:
    Published
    DOI:
    10.26508/LSA.202000665 - link to the publication
  2. Molecular basis for the bifunctional Uba4–Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation
    Authors:
    Pabis M, Termathe M, Ravichandran KE, Kienast SD, Krutyhołowa R, Sokołowski M, Jankowska U, Grudnik P, Leidel SA and Glatt S
    Academic press:
    EMBO Journal (rok: 2020, tom: 39, strony: e105087), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.15252/embj.2020105087 - link to the publication
  3. A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype
    Authors:
    1.Kojic M, Abbassi NEH, Lin TY, Jones A, Wakeling EL, Clement E, Nakou V, Singleton M, Dobosz D, Kaliakatsos M, Glatt S and Wainwright BJ
    Academic press:
    Journal of Human Genetics (rok: 2023, tom: 2, strony: Online ahead of print), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s10038-023-01135-3 - link to the publication
  4. E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
    Authors:
    Ravichandran KE, Kaduhr L, Skupien‐Rabian B, Shvetsova E, Sokołowski M, Krutyhołowa RC, Kwasna D, Brachmann C, Lin S, Guzman Perez S, Wilk P, Kösters M, Grudnik P, Jankowska U, Leidel SA, Schaffrath R, Glatt S
    Academic press:
    The EMBO Journal (rok: 2022, tom: 41(20), strony: e111318), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.15252/embj.2022111318 - link to the publication
  5. Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops
    Authors:
    Krutyhołowa R, Reinhardt-Tews A, Chramiec-Głąbik A, Breunig KD, Glatt S
    Academic press:
    Current Genetics (rok: 2020, tom: 66, strony: 823-833), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00294-020-01070-2 - link to the publication
  6. Cryo‐EM structure of the fully assembled Elongator complex
    Authors:
    Jaciuk M, Scherf D, Kaszuba K, Gaik M, Rau A, Koscielniak A, Krutyhołowa R, Rawski M, Indyka P, Graziadei A, Chramiec‐Głąbik A, Biela A, Dobosz D, Lin TY, Abbassi N, Hammermeister A, Rappsilber J, Kosinski J, Schaffrath R and Glatt S
    Academic press:
    Nucleic Acids Research (rok: 2023, tom: gkac1232, strony: online ahead of print.), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac1232 - link to the publication
  7. How Elongator Acetylates tRNA Bases
    Authors:
    Abbassi NE, Biela A, Glatt S and Lin TY
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45304), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21218209 - link to the publication

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