Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Comprehensive evaluation of biomedical potential of novel maroporous cryogel-based biomaterials produced by freeze-drying technique combined with foaming agent

2018/31/B/ST8/00945

Keywords:

biomaterials tissue engineering regenerative medicine cell culture in vitro stem cells nanoparticles plasma surface modification

Descriptors:

  • ST8_8: Mechanics of solids
  • NZ1_8: Tissue engineering
  • ST5_6: Porous materials, ceramics, glasses

Panel:

ST8 - Production and processes engineering: modelling, product design, process design and control, construction methods and engineering, power units and systems

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Biomedyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agata Przekora-Kuśmierz 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 347 600 PLN

Project start date (Y-m-d): 2019-07-22

Project end date (Y-m-d): 2022-11-21

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Napylarka niskopróżniowa (85 000 PLN)
  2. Skaningowy mikroskop elektronowy (SEM) NeoScope JCM-6000 PLUS z jednostką sterującą (340 000 PLN)
  3. Zestaw pipet elektronicznych z ładowarką karuzelową (2 szt.) (40 000 PLN)
  4. Laptop z dedykowaną kartą graficzną.
  5. Goniometr do pomiaru kąta zwilżania z jednostką sterującą (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  • Articles in post-conference publications (11)
  • Book publications / chapters in book publications (2)
  1. Bioactive curdlan/agarose dressing enriched with gentamicin for infected wounds – pilot studies
    Authors:
    Wojcik M., Wilczynska A., Vivcharenko V., Kazimierczak P., Adaszek L., Przekora A.
    Academic press:
    Inżynieria Biomateriałów/Engineering of Biomaterials (rok: 2021, tom: 160, strony: 45329), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Status:
    Published
    DOI:
    10.34821/eng.biomat.160.2021.2-7 - link to the publication
  2. Biological response to macroporous chitosan-agarose bone scaffolds comprising Mg- and Zn-doped nano-hydroxyapatite
    Authors:
    Kazimierczak P., Kolmas J., Przekora A.
    Academic press:
    Int. J. Mol. Sci. (rok: 2019, tom: 20, strony: 3835), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ijms20153835 - link to the publication
  3. Development and optimization of the novel fabrication method of highly macroporous chitosan/agarose/nanohydroxyapatite bone scaffold for potential regenerative medicine applications
    Authors:
    Kazimierczak P., Palka K., Przekora A.
    Academic press:
    Biomolecules (rok: 2019, tom: 9, strony: 434), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/biom9090434 - link to the publication
  4. Cellular response to vitamin C-enriched chitosan/agarose film with potential application as artificial skin substitute for chronic wound treatment
    Authors:
    Vivcharenko V., Wojcik M., Przekora A.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1185), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/cells9051185 - link to the publication
  5. Development of a new production method of foam-like wound dressings for skin regeneration
    Authors:
    Vivcharenko V., Kazimierczak P., Wójcik M., Przekora A.
    Academic press:
    Inżynieria Biomateriałów/Engineering of Biomaterials (rok: 2019, tom: 22(152), strony: 16-20), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Status:
    Published
    DOI:
    Brak - link to the publication
  6. Effect of vitamin C/hydrocortisone immobilization within curdlan-based wound dressings on in vitro cellular response in context of the management of chronic and burn wounds
    Authors:
    Wojcik M., Kazimierczak P., Vivcharenko V., Koziol M., Przekora A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11474), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ijms222111474 - link to the publication
  7. Elastic and biodegradable chitosan/agarose film revealing slightly acidic pH for potential applications in regenerative medicine as artificial skin graft
    Authors:
    Vivcharenko V., Benko A., Palka K., Wojcik M., Przekora A.
    Academic press:
    Int. J. Bio. Macromol. (rok: 2020, tom: 164, strony: 172-183), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2020.07.099 - link to the publication
  8. Novel synthesis method combining a foaming agent with freeze-drying to obtain hybrid highly macroporous bone scaffolds
    Authors:
    Kazimierczak P., Benko A., Palka K., Canal C., Kolodynska D., Przekora A.
    Academic press:
    J. Mater. Sci. Technol. (rok: 2020, tom: 43, strony: 52-63), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmst.2020.01.006 - link to the publication
  9. The chitosan/agarose/nanoHA bone scaffold-induced M2 macrophage polarization and its effect on osteogenic differentiation in vitro
    Authors:
    Kazimierczak P., Koziol M., Przekora A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1109), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ijms22031109 - link to the publication
  10. A concise review on tissue engineered artificial skin grafts for chronic wound treatment: can we reconstruct functional skin tissue in vitro?
    Authors:
    Przekora A.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1622), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/cells9071622 - link to the publication
  11. Modifications of wound dressings with bioactive agents to achieve improved pro-healing properties
    Authors:
    Vivcharenko V., Przekora A.
    Academic press:
    Applied Sciences (rok: 2021, tom: 11, strony: 4114), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/app11094114 - link to the publication
  12. Surface modifications of biomaterial with different cold plasma reactors to improve cell adhesion
    Authors:
    Terebun P., Wójcik M., Trzaskowska M., Kwiatkowski M., Zarzeczny D., Kazimierczak P., Pawłat J., Przekora A.
    Academic press:
    Inżynieria Biomateriałów/Engineering of Biomaterials (rok: 2022, tom: 165, strony: 45328), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Status:
    Published
    DOI:
    10.34821/eng.biomat.165.2022.2-6 - link to the publication
  13. Biocompatible curdlan-based biomaterials loaded with gentamicin and Zn-doped nano-hydroxyapatite as promising dressing materials for the treatment of infected wounds and prevention of surgical site infections
    Authors:
    Wojcik M., Kazimierczak P., Belcarz A., Wilczynska A., Vivcharenko V., Pajchel L., Adaszek L., Przekora A.
    Academic press:
    Biomaterials Advances (rok: 2022, tom: 139, strony: 213006), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2022.213006 - link to the publication
  14. Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management
    Authors:
    Vivcharenko V., Wojcik M., Palka K., Przekora A.
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 1211), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ma14051211 - link to the publication
  15. Noncytotoxic zinc-doped nanohydroxyapatite-based bone scaffolds with strong bactericidal, bacteriostatic, and antibiofilm activity
    Authors:
    Kazimierczak P., Golus J., Kolmas J., Wojcik M., Kolodynska D., Przekora A.
    Academic press:
    Biomaterials Advances (rok: 2022, tom: 139, strony: 213011), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2022.213011 - link to the publication
  16. Superabsorbent curdlan-based foam dressings with typical hydrocolloids properties for highly exuding wound management
    Authors:
    Wojcik M., Kazimierczak P., Benko A., Palka K., Vivcharenko V., Przekora A.
    Academic press:
    Materials Science & Engineering C-Materials for Biological Applications (rok: 2021, tom: 124, strony: 112068), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2021.112068 - link to the publication
  1. Curdlan-based biomaterial enriched with zinc-doped hydroxyapatite as antibacterial dressing
    Authors:
    Wojcik M., Kazimierczak P., Belcarz A., Vivcharenko V., Przekora A.
    Conference:
    XXXI Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2022, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 13-16 X 2022
    Status:
    Published
  2. Vitamin c enriched biocompatible and biodegradable film obtained from marine-derived natural polysaccharides
    Authors:
    Vivcharenko V., Wójcik M., Przekora A.
    Conference:
    XXXI Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2022, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 13-16 X 2022
    Status:
    Published
  3. Highly macroporous chitosan/agarose/HA bone scaffold produced by combination of freeze-drying with gas-foaming agent
    Authors:
    Kazimierczak P., Palka K., Przekora A.
    Conference:
    XXVIII Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2019, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 10-13 X 2019
    Status:
    Published
  4. In vitro evaluation of cellular response to novel agarose/chitosan/HA scaffold
    Authors:
    Kazimierczak P., Przekora A.
    Conference:
    XXVIII Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2019, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 10-13 X 2019
    Status:
    Published
  5. Novel highly biocompatible chitosan/agarose film for potential application as skin substitute
    Authors:
    Vivcharenko V., Kazimierczak P., Wójcik M., Przekora A.
    Conference:
    XXVIII Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2019, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 10-13 X 2019
    Status:
    Published
  6. Effect of zinc ions incorporated within the structure of bone scaffold on cellular response and antibacterial activity in vitro
    Authors:
    Kazimierczak P., Golus J., Wojcik M., Kolmas J., Przekora A.
    Conference:
    XXXI Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2022, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 13-16 X 2022
    Status:
    Published
  7. Superabsorbent vitamin c-enriched chitosan-agarose biomaterial for exuding wound management
    Authors:
    Vivcharenko V., Wojcik M., Palka K., Przekora A.
    Conference:
    XXX Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2021, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 14-17 X 2021
    Status:
    Published
  8. Bioactive hydrocolloid-type biomaterials for potential management of highly exuding wounds
    Authors:
    Wojcik M., Kazimierczak P., Vivcharenko V., Przekora A.
    Conference:
    XXX Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2021, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 14-17 X 2021
    Status:
    Published
  9. Novel agarose/β-1,3-D-glucan foam as promising biomaterial for skin regeneration applications
    Authors:
    Wójcik M., Kazimierczak P., Vivcharenko V., Przekora A.
    Conference:
    XXVIII Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2019, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 10-13 X 2019
    Status:
    Published
  10. The effect of nanoHA-based biomaterial on macrophage polarization and osteogenic differentiation in co-culture system in vitro
    Authors:
    Kazimierczak P., Przekora A.
    Conference:
    XXX Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2021, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 14-17 X 2021
    Status:
    Published
  11. The use of a hydrocolloid dressing on a chronic wound - case study
    Authors:
    Wilczynska A., Wojcik M., Przekora A., Zietek J., Adaszek L.
    Conference:
    XXX Annual Conference: Biomaterials in Medicine and Veterinary Medicine (rok: 2021, ), Wydawca: Polskie Stowarzyszenie Biomateriałów w Krakowie
    Data:
    konferencja 14-17 X 2021
    Status:
    Published
  1. Nanocomposite scaffolds and coatings for wound healing and infection control
    Authors:
    Sebastian Wilk, Agata Przekora, Paulina Kazimierczak, David Medina-Cruz, Lidia Martínez, Catherine O'Connell, Linh B. Truong, Katarzyna Reczyńska-Kolman, Hamed Barabadi, Jorge L. Cholula-Diaz, Elżbieta Pamuła, Yves Huttel, José Miguel García-Martín, Thomas J. Webster, Aleksandra Benko
    Book:
    Antimicrobial activity of nanoparticles : applications in wound healing and infection treatment (rok: 2023, tom: -, strony: 69-99), Wydawca: Elsevier
    Status:
    Published
  2. Nanomaterials to aid wound healing and infection control
    Authors:
    Aleksandra Benko, Katarzyna Reczyńska-Kolman, David Medina-Cruz, Jorge L. Cholula-Diaz, Catherine O'Connell, Linh B. Truong, Lidia Martínez, Paulina Kazimierczak, Agata Przekora, Sebastian Wilk, Hamed Barabadi, Yves Huttel, José Miguel García-Martín, Elżbieta Pamuła, Thomas J. Webster.
    Book:
    Antimicrobial activity of nanoparticles : applications in wound healing and infection treatment (rok: 2023, tom: -, strony: 19-67), Wydawca: Elsevier
    Status:
    Published

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