Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Protein citrullination as a hallmark of Porphyromonas gingivalis pathogenicity

2018/30/A/NZ5/00650

Keywords:

Porphyomonas gingivalis parodontoza rheumatoid arthritis citrullin peptidyl arginine deiminase prostaglandin fibroblasts

Descriptors:

  • NZ5_3:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Stanisław Potempa 

Number of co-investigators in the project: 8

Call: MAESTRO 10 - announced on 2018-06-15

Amount awarded: 3 762 000 PLN

Project start date (Y-m-d): 2019-04-25

Project end date (Y-m-d): 2023-12-24

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
    Authors:
    Martin M, Nilsson SC, Eikrem D, Fromell K, Scavenius C, Vogt LM, Bielecka E, Potempa J, Enghild JJ, Nilsson B, Ekdahl KN, Kapetanovic MC, Blom AM
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1203506), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1203506 - link to the publication
  2. Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from P. gingivalis in advanced periodontitis
    Authors:
    Grzegorz P Bereta, Karolina Strzelec, Katarzyna Łazarz-Bartyzel, Agata Dziedzic-Kowalska, Zuzanna Nowakowska, Anna Krutyhołowa, Ewa Bielecka, Tomasz Kantyka, Aleksander M Grabiec, Tomasz Kaczmarzyk, Maria Chomyszyn-Gajewska, Jan Potempa, Katarzyna Gawron
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 45670), Wydawca: frontiersin.org
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1355357 - link to the publication
  3. Exhaled Nitric Oxide Reflects Immune Reactions of Airways in 2 Early Rheumatoid Arthritis
    Authors:
    Tomas Weitoft, Johan Rönnelid, Anders Lind, Charlotte de Vries, Anders Larsson 5, Barbara Potempa, Jan Potempa, Alf Kastbom, Klara Martinsson 8, Karin Lundberg and Marieann Högman
    Academic press:
    Biomedicines (rok: 2024, tom: 12, strony: 964), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines12050964 - link to the publication
  4. Impact of increased Porphyromonas gingivalis peptidylarginine deiminase (PPAD) activity on oral microbiota composition and severity of chronic periodontitis
    Authors:
    Marta Kaminska, Noemie A.M. Dudzinska, Tülay Yucel-Lindberg, Birgitta Söder, Jan Potempa and Piotr M. Mydel
    Academic press:
    Journal of Oral Microbiology , Wydawca: Tylor & Francis
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Application of the In Vitro HoxB8 Model System to Characterize the Contributions of Neutrophil-LPS Interaction to Periodontal Disease
    Authors:
    Sochalska M, Stańczyk MB, Użarowska M, Zubrzycka N, Kirschnek S, Grabiec AM, Kantyka T, Potempa J.
    Academic press:
    Pathogens (rok: 2020, tom: 9, strony: 530), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/pathogens9070530 - link to the publication
  6. Pros and cons of causative association between periodontitis and rheumatoid arthritis
    Authors:
    Koziel, J., Potempa, J
    Academic press:
    Periodontology 2000 (rok: 2022, tom: 89, strony: 83-98), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/prd.12432 - link to the publication
  7. Citrullinome of Porphyromonas gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides.
    Authors:
    Larsen DN, Mikkelsen CE, Kierkegaard M, Bereta GP, Nowakowska Z, Kaczmarek JZ, Potempa J, Højrup P.
    Academic press:
    Mol Cell Proteomics (rok: 2020, tom: 19, strony: 167-180), Wydawca: ASMBM
    Status:
    Published
    DOI:
    10.1074/mcp.RA119.001700 - link to the publication
  8. Host and bacterial factors linking periodontitis and rheumatoid arthritis
    Authors:
    Anna Krutyhołowa, Karolina Strzelec,, Agata Dziedzic,, Grzegorz P Bereta, Katarzyna Łazarz-Bartyzel, Jan Potempa , Katarzyna Gawron
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 980805), Wydawca: www.frontiers.com
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.980805 - link to the publication
  9. TLR2 activation by Porphyromonas gingivalis requires both PPAD activity and fimbriae
    Authors:
    Aleksandra Wielento, Grzegorz Bereta, Katarzyna Łagosz-Ćwik, Sigrun Eick, Richard Lamont, Aleksander M. Grabiec, Jan Potempa
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 823685), Wydawca: www.frontiers.com
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.823685 - link to the publication
  10. Treatment of severe periodontitis may improve clinical disease activity in otherwise treatment-refractory rheumatoid arthritis patients.
    Authors:
    Möller B, Bender P, Eick S, Kuchen S, Maldonado A, Potempa J, Reichenbach S, Sculean A, Schwenzer A, Villiger PM, Wong A, Midwood KS.
    Academic press:
    Rheumatology (Oxford) (rok: 2020, tom: 59, strony: 243-245), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/rheumatology/kez287 - link to the publication
  11. HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis
    Authors:
    Lagosz KB, Bysiek A, Macina JM, Bereta GP, Kantorowicz M, Lipska W, Sochalska M, Gawron K, Kaczmarzyk T, Chomyszyn-Gajewska M, Fossati G, Potempa J, Grabiec AM
    Academic press:
    J. Dent. Res. (rok: 2020, tom: 99, strony: 98-106), Wydawca: International & American Association for Dental Research
    Status:
    Published
    DOI:
    10.1177/0022034519885088 - link to the publication
  12. Peptidylarginine Deiminase of Porphyromonas gingivalis Modulates the Interactions between Candida albicans Biofilm and Human Plasminogen and High-Molecular-Mass Kininogen
    Authors:
    Justyna Karkowska-Kuleta, Magdalena Surowiec, Mariusz Gogol, Joanna Koziel, Barbara Potempa, Jan Potempa, Andrzej Kozik and Maria Rapala-Kozik
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 2495), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072495 - link to the publication
  13. Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis
    Authors:
    Prucsi Z, Zimny A, Płonczyńska A, Zubrzycka N, Potempa J, Sochalska M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 12922), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241612922 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy