Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dissecting of the novel mechanisms in multi-drug resistance associated with vault's proteins and translation initiation factors in cancer diseases

2018/30/E/NZ7/00614

Keywords:

cellular vaults protein biosynthesis translation control MVP TEP1 vPARP

Descriptors:

  • NZ3_1:
  • NZ1_1:
  • NZ7_15:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Witold Szaflarski 

Number of co-investigators in the project: 4

Call: SONATA BIS 8 - announced on 2018-06-15

Amount awarded: 1 999 000 PLN

Project start date (Y-m-d): 2019-03-29

Project end date (Y-m-d): 2024-03-28

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. MVP expression facilitates tumor cell proliferation and migration supporting the metastasis of colorectal cancer cells
    Authors:
    Pietras P, Leśniczak-Staszak M, Kasprzak A, Andrzejewska M, Jopek K, Sowiński M, Ruciński M, Lyons SM, Ivanov P, Szaflarski W
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(22), strony: 12121), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222212121 - link to the publication
  2. Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention
    Authors:
    Leśniczak-Staszak M, Pietras M, Ruciński M, Johnston R, Sowiński M, Andrzejewska M, Nowicki M, Gowin E, Lyons SM, Ivanov P, Szaflarski W
    Academic press:
    Journal of Cell Science (rok: 2024, tom: 137(12), strony: jcs261825), Wydawca: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/jcs.261825 - link to the publication
  3. Molecular structure of stress granules and their role in the eukaryotic cell
    Authors:
    Pietras P, Leśniczak M, Sowiński M, Szaflarski W
    Academic press:
    Medical Journal of Cell Biology (rok: 2021, tom: 9(1), strony: 34-41), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/acb-2021-0006 - link to the publication
  4. Role of Alternatively Spliced Messenger RNA (mRNA) Isoforms of the Insulin-Like Growth Factor 1 (IGF1) in Selected Human Tumors.
    Authors:
    Kasprzak Aldona, Szaflarski Witold
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(19), strony: 6995), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21196995 - link to the publication
  5. Analysis of genes involved in immune response in children with HLH – case series
    Authors:
    Gowin E, Szaflarski W, Januszkiewicz-Lewandowska D
    Status:
    Accepted for publication

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