Projects funded by the NCN

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Information of the project and the call

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The role of microbiota-triggered antigen stimulation in development and progression of chronic lymphocytic leukemia

2018/29/B/NZ5/02706

Keywords:

chronic lymphocytic leukemia B-cell receptor leukemogenesis microbiome

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Giannopoulos 

Number of co-investigators in the project: 6

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 3 098 800 PLN

Project start date (Y-m-d): 2019-02-06

Project end date (Y-m-d): 2024-12-05

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. The predominant prognostic significance of NOTCH1 mutation defined by emulsion PCR in chronic lymphocytic leukemia
    Authors:
    Katarzyna Skórka, Michał Chojnacki, Marta Masternak, Agnieszka Karczmarczyk, Edyta Subocz, Ewa Wawrzyniak, Krzysztof Giannopoulos
    Academic press:
    Cancer Manag. Res (rok: 2021, tom: vol. 13, strony: s. 3663-3674), Wydawca: Dave Press
    Status:
    Published
    DOI:
    10.2147/CMAR.S302245 - link to the publication
  2. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL
    Authors:
    Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis ZA, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper R, Sutton LA, Baliakas P, Scarfò L, van Gastel EJ, Armand M, Tausch E, Biderman B, Baer C, Bagnara D, Navarro A, de Septenville A, Guido V, Mitterbauer-Hohendanner G, Dimovski A, Brieghel C, Lawless S, Meggendorfer M, Stranska K, Ritgen M, Facco M, Tresoldi C, Visentin A, Patriarca A, Catherwood M, Bonello L, Sudarikov A, Vanura K, Roumelioti M, Skuhrova Francova H, Moysiadis T, Veronese SM, Giannopoulos K, Mansouri L, Karan-Djurasevic T, Sandaltzopoulos R, Bödör C, Fais F, Kater AP, Panovska-Stavridis I, Rossi D, Alshemmari S, Panagiotidis P, Costeas PA, Espinet B, Antic D, Foroni L, Montillo M, Trentin L, Stavroyianni N, Gaidano G, Francia di Celle P, Niemann CU, Campo E, Anagnostopoulos A, Pott C, Fischer K, Hallek M, Oscier DG, Stilgenbauer S, Haferlach C, Jelinek DF, Chiorazzi N, Pospisilova S, Lefranc MP, Kossida S, Langerak AW, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K.
    Academic press:
    Blood (rok: 2020, tom: Blood., strony: Sep 29:blood.2020007039.Epub ahead of print.), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood.2020007039 - link to the publication
  3. Mean Platelet Volume Has Prognostic Value in Chronic Lymphocytic Leukemia.
    Authors:
    Masternak M, Puła B, Knap J, Waszczuk-Gajda A, Drozd-Sokołowska J, Wdowiak K, Grosicki S, Kozłowska I, Kaźmierczak M, Łabędź A, Szukalski Ł, Wiśniewski K, Subocz E, Hałka J, Szymczyk A, Hus M, Jamroziak K, Giannopoulos K.
    Academic press:
    Cancer Manag Res. (rok: 2020, tom: 12, strony: 9977-9985), Wydawca: Dove Press
    Status:
    Published
    DOI:
    10.2147/CMAR.S246385 - link to the publication
  4. The role of NPM1 alternative splicing in patients with chronic lymphocytic leukemi
    Authors:
    Szelest, Monika ; Masternak, Marta ; Zajac, Malgorzata ; Chojnacki, Michal ; Skórka, Katarzyna ; Zaleska, Joanna ; Karczmarczyk, Agnieszka ; Stasiak, Grazyna ; Wawrzyniak, Ewa ; Kotkowska, Aleksandra ; Siemieniuk-Rys, Monika ; Purkot, Joanna ; Subocz, Edyta ; Cichocka, Edyta ; Tomczak, Waldemar ; Zawirska, Daria ; Giannopoulos, Krzysztof; Valdés, Jesús
    Academic press:
    PloS one (rok: 2022, tom: 17, strony: 45305), Wydawca: San Francisco: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0276674 - link to the publication
  5. Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations? NOTCH1, SF3B1,MYD88, BIRC3
    Authors:
    Maciej Putowski, Krzysztof Giannopoulos
    Academic press:
    Jurnal of Clinical Medicine (rok: 2021, tom: 10(16), 3735, strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10163735 - link to the publication
  6. Aberrant expression of TLR2, TLR7, TLR9, splicing variants of TLR4 and MYD88 in chronic lymphocytic leukemia patients
    Authors:
    Katarzyna Skorka, Paulina Wlasiuk, Agnieszka Karczmarczyk, Krzysztof Giannopoulos
    Academic press:
    Jurnal of Clinical Medicine (rok: 2021, tom: 10(4), 867, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10040867 - link to the publication
  7. The prognostic impact of CD49d protein and mRNA expression in patients with chronic lymphocytic leukaemia
    Authors:
    Maciej Putowski, Katarzyna Skórka, Monika Włodarczyk, Waldemar Tomczak, Edyta Subocz, Janusz Hałka, Krzysztof Giannopoulos
    Academic press:
    Arch Med Sci (rok: 2020, tom: x, strony: x), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/aoms/130646 - link to the publication

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