Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Stimulation of various autophagy induction pathways in the light of efficiency of glycosaminoglycan degradation in neuronopathic types of mucopolysaccharidoses

2018/29/N/NZ2/00802

Keywords:

mucopolysaccharidosis therapy of mucopolysaccharidosis autophagy autophagy pathways autophagy inducers

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_11: Genetic epidemiology
  • NZ3_7: Signal transduction

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Lidia Gaffke 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2019-02-21

Project end date (Y-m-d): 2023-02-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. Activities of (Poly)phenolic Antioxidants and Other Natural Autophagy Modulators in the Treatment of Sanfilippo Disease: Remarkable Efficacy of Resveratrol in Cellular and Animal Models.
    Authors:
    Rintz E, Podlacha M, Cyske Z, Pierzynowska K, Węgrzyn G, Gaffke L.
    Academic press:
    Neurotherapeutics (rok: 2023, tom: 20, strony: 254-271), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s13311-022-01323-7 - link to the publication
  2. Changes in cellular processes occurring in mucopolysaccharidoses as underestimated pathomechanisms of these diseases.
    Authors:
    Gaffke L, Pierzynowska K, Podlacha M, Brokowska J, Węgrzyn G.
    Academic press:
    Cell Biology International (rok: 2021, tom: 45, strony: 498-506), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/cbin.11275 - link to the publication
  3. Therapeutic potential of lithium chloride and valproic acid against neuronopathic types of mucopolysaccharidoses through induction of the autophagy process.
    Authors:
    Gaffke L, Firyn N, Rintz E, Pierzynowska K, Piotrowska E, Mazur-Marzec H, Węgrzyn G.
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2023, tom: 747, strony: 45302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2023.109754 - link to the publication
  1. Chapter 14 - Hopes and disappointments related to the use of flavonoids in therapeutical approaches
    Authors:
    Lidia Gaffke, Karolina Pierzynowska, Zuzanna Cyske, Estera Rintz, Magdalena Podlacha, Grzegorz Mincewicz, Grzegorz Węgrzyn
    Book:
    Modulation of Oxidative Stress Biochemical, Physiological and Pharmacological Aspects (rok: 2023, tom: -, strony: 199-210), Wydawca: Elsevier
    Status:
    Published

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