Projects funded by the NCN
The role of alpha-lipoic acid in the brain complications of insulin resistance
2018/29/N/NZ4/02011
Keywords:
insulin resistance oxidative stress sphingolipids brain α-lipoic acid
Descriptors:
- NZ4_11: Metabolism
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim
woj. podlaskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 15 - announced on 2018-03-15
Amount awarded: 140 000 PLN
Project start date (Y-m-d): 2019-01-10
Project end date (Y-m-d): 2021-01-09
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant RatsAuthors:Mateusz Maciejczyk ,Ewa Żebrowska, Miłosz Nesterowicz ,Małgorzata Żendzian-Piotrowska, Anna ZalewskaAcademic press:Oxidative Medicine and Cellular Longevity (rok: 2022, tom: 2022, strony: 21), Wydawca: HindawiStatus:PublishedDOI:10.1155/2022/7450514 - link to the publication
- Insulin Resistance and Oxidative Stress in the Brain: What's New?Authors:Mateusz Maciejczyk, Ewa Żebrowska, Adrian ChabowskiAcademic press:International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 45309), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms20040874 - link to the publication
- α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid AccumulationAuthors:Mateusz Maciejczyk, Ewa Żebrowska, Miłosz Nesterowicz, Elżbieta Supruniuk, Barbara Choromańska, Adrian Chabowski, Małgorzata Żendzian-Piotrowska, Anna ZalewskaAcademic press:Journal of Inflammation Research (rok: 2022, tom: 15, strony: 2295-2312), Wydawca: DovepressStatus:PublishedDOI:10.2147/JIR.S358799 - link to the publication