Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Does short C-terminal peptide of alpha1-antitrypsin modify the susceptibility of PiZZ alpha-1-antitrypsin deficiency carriers to develop lung disease – insight into its biological activity towards human neutrophils.

2018/29/B/NZ5/02346

Keywords:

alpha-1 antitrypsin variants alpha-1 antitrypsin deficiency neutrophils C-terminal peptide COPD lung emphysema

Descriptors:

  • NZ5_3:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Gruźlicy i Chorób Płuc

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Agnieszka Chorostowska-Wynimko 

Number of co-investigators in the project: 4

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 529 014 PLN

Project start date (Y-m-d): 2019-01-28

Project end date (Y-m-d): 2024-01-27

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Plasma markers of COVID-19 severity: a pilot study
    Authors:
    Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner & Tobias Welte
    Academic press:
    Respiratory Research (rok: 2022, tom: 23, strony: -), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12931-022-02272-7 - link to the publication
  2. Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
    Authors:
    Kokilavani Sivaraman, Sabine Wrenger, Bin Liu, Dirk Schaudien, Christina Hesse, Gema Gomez-Mariano, Sara Perez-Luz,Katherina Sewald, David DeLuca, Maria J. Wurm, Paco Pino,Tobias Welte,Beatriz Martinez-Delgado, Sabina Janciauskiene1
    Academic press:
    Journal of Leukocyte Biology (rok: 2023, tom: 113, strony: 58-70), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jleuko/qiac004 - link to the publication
  3. SERPINA1 and More? A Putative Genetic Contributor to Pulmonary Dysfunction in Alpha-1 Antitrypsin Deficiency
    Authors:
    Aleksandra Jezela-Stanek, Joanna Chorostowska-Wynimk
    Academic press:
    Journal of Clinical Medicine (rok: 2023, tom: 12, strony: 1708), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm12051708 - link to the publication
  4. Plasma markers of COVID-19 severity: a pilot study
    Authors:
    Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner & Tobias Welte
    Academic press:
    Respiratory Research (rok: 2022, tom: 23, strony: -), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12931-022-02272-7 - link to the publication
  5. An association between plasma levels of α2-macroglobulin and α1-antitrypsin in PiMM and PiZZ individuals differing in COPD presentation
    Authors:
    Urszula Lechowicz, Beatriz Martinez-Delgado, Bin Liu, Sabine Wrenger, Adriana Rozy, Aneta Zdral, David S. DeLuca, Tobias Welte, Sabina Janciauskiene, Joanna Chorostowska-Wynimko,
    Academic press:
    Clinical Biochemstry (rok: 2024, tom: 126, strony: 110736), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clinbiochem.2024.110736 - link to the publication
  6. Computational Tools to Assist in Analyzing Effects of the SERPINA1 Gene Variation on Alpha-1 Antitrypsin (AAT)
    Authors:
    Mróz, J.; Pelc, M.; Mitusińska, K.; Chorostowska-Wynimko, J.; Jezela-Stanek, A.
    Academic press:
    Genes (rok: 2024, tom: 15 (3), strony: 340), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes15030340 - link to the publication
  7. An association between plasma levels of α2-macroglobulin and α1-antitrypsin in PiMM and PiZZ individuals differing in COPD presentation
    Authors:
    Urszula Lechowicz, Beatriz Martinez-Delgado, Bin Liu, Sabine Wrenger, Adriana Rozy, Aneta Zdral, David S. DeLuca, Tobias Welte, Sabina Janciauskiene, Joanna Chorostowska-Wynimko,
    Academic press:
    Clinical Biochemstry (rok: 2024, tom: 126, strony: 110736), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.clinbiochem.2024.110736 - link to the publication
  8. Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein
    Authors:
    Urszula Lechowicz, Stefan Rudzinski, Aleksandra Jezela-Stanek, Sabina Janciauskiene, Joanna Chorostowska-Wynimko
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 2, strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239187 - link to the publication

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