Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effect of tumor microenvironment on efficiency of melanoma targeted therapy

2018/29/B/NZ5/00967

Keywords:

microenvironment melanoma EGFR c-Met lapatinib gefitinib foretinib

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dorota Nowak 

Number of co-investigators in the project: 7

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 431 960 PLN

Project start date (Y-m-d): 2019-02-04

Project end date (Y-m-d): 2023-02-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wytrząsarka do mikropłytek z inkubacją (7 000 PLN)
  2. Moduł fluorescencyjny do mikroskopu odwróconego z kamerą, komputerem, monitorem i oprogramowaniem (93 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Melanoma stimulates the proteolytic activity of HaCaT keratinocytes
    Authors:
    Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
    Academic press:
    Cell Commun Signal. (rok: 2022, tom: 20, strony: 146), Wydawca: BMC part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-022-00961-w - link to the publication
  2. Hypoxia and extracellular acidification as drivers of melanoma progression and drug resistance
    Authors:
    E. Dratkiewicz, A. Simiczyjew, J. Mazurkiewicz, M. Ziętek., R. Matkowski, D. Nowak
    Academic press:
    Cells (rok: 2021, tom: 10(4), strony: 862), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10040862 - link to the publication
  3. Melanoma cells induce dedifferentiation and metabolic changes of adipocytes present in the tumor niche
    Authors:
    Aleksandra Simiczyjew, Justyna Wądzyńska, Katarzyna Pietraszek-Gremplewicz, Magdalena Kot, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2023, tom: 28, strony: 58), Wydawca: BMC part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s11658-023-00476-3 - link to the publication
  4. Melanoma cells with diverse invasive potential differentially induce the activation of normal human fibroblasts
    Authors:
    J. Mazurkiewicz, A. Simiczyjew, E. Dratkiewicz, K. Pietraszek-Gremplewicz, M. Majkowski, M. Kot, M. Ziętek, R. Matkowski, D. Nowak
    Academic press:
    Cell Communication and Signalling (rok: 2022, tom: 20, strony: 63), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-022-00871-x - link to the publication
  5. The Influence of Tumor Microenvironment on Immune Escape of Melanoma
    Authors:
    Aleksandra Simiczyjew, Ewelina Dratkiewicz, Justyna Mazurkiewicz, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, 8359, strony: 45319), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21218359 - link to the publication
  6. Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy
    Authors:
    Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Marcin Ziętek, Rafał Matkowski, Dorota Nowak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, 529, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020529 - link to the publication
  7. Combinations of EGFR and MET inhibitors reduce viability and invasiveness of mucosal melanoma cells
    Authors:
    Aleksandra Simiczyjew, Justyna Wądzyńska, Magdalena Kot, Marcin Ziętek, Rafał Matkowski, Mai P. Hoang, Piotr Donizy, Dorota Nowak
    Academic press:
    Journal of Cellular and Molecular Medicine , Wydawca: Wiley
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication

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