Projects funded by the NCN
Why Nature introduced selenium to wobble nucleosides in transfer RNA?
2018/29/B/ST5/02509
Keywords:
modified nucleosides transfer RNA tRNA selenium seleno-uridine oxidative stress mass spectrometry chemical synthesis
Descriptors:
- ST5_16:
- NZ3_1: Cell biology
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: OPUS 15 - announced on 2018-03-15
Amount awarded: 1 828 600 PLN
Project start date (Y-m-d): 2019-01-24
Project end date (Y-m-d): 2024-01-23
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (5)
- Book publications / chapters in book publications (1)
- Escherichia coli tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of S-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNAAuthors:Patrycja Szczupak , Malgorzata Sierant ,* Ewelina Wielgus , Ewa Radzikowska-Cieciura, Katarzyna Kulik, Agnieszka Krakowiak, Paulina Kuwerska, Grazyna Leszczynska and Barbara NawrotAcademic press:Cells (rok: 2022, tom: 11, strony: 1522), Wydawca: MDPIStatus:PublishedDOI:10.3390/cells11091522 - link to the publication
- 2-Selenouridine, a Modified Nucleoside of Bacterial tRNAs, Its Reactivity in the Presence of Oxidizing and Reducing ReagentsAuthors:Katarzyna Kulik ,* Klaudia Sadowska, Ewelina Wielgus, Barbara Pacholczyk-Sienicka, Elzbieta Sochacka and Barbara NawrotAcademic press:Int. J. Mol. Sci. (rok: 2022, tom: 23, strony: 7973), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms23147973 - link to the publication
- Different Oxidation Pathways of 2-Selenouracil and 2-Thiouracil, Natural Components of Transfer RNAAuthors:Kulik, K.; Sadowska, K.; Wielgus, E.; Pacholczyk-Sienicka, B.; Sochacka, E.; Nawrot, B.Academic press:Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 5956), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms21175956 - link to the publication
- C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA Codons.Authors:Leszczynska G., Cypryk M., Gostynski B., Sadowska K., Herman P., Bujacz G., Lodyga-Chruscinska E., Sochacka E., Nawrot B.Academic press:Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 2882), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms21082882 - link to the publication
- Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic functionAuthors:Patrycja Szczupak, Ewa Radzikowska-Cieciura 1, Katarzyna Kulik, Rafał Madaj, Małgorzata Sierant, Agnieszka Krakowiak, Barbara Nawrot *Academic press:Bioorganic Chemistry (rok: 2022, tom: 122, strony: 105739), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bioorg.2022.105739 - link to the publication
- Sulfur and Selenium modified bacterial tRNAsAuthors:B. Nawrot, M. Sierant, and P. SzczupakBook:Handbook of Chemical Biology of Nucleic Acids (rok: 2023, tom: 1, strony: 12420), Wydawca: Springer Nature Singapore Pte Ltd. 2023Status:Published