Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Hypoxia in combinatory treatment of murine pancreatic tumor

2018/29/B/NZ5/02954

Keywords:

pancreatic cancer chemotherapy USG EPR hypoxia radiotherapy hyperthermia nanopręty złota

Descriptors:

  • NZ1_3:
  • NZ4_12:
  • NZ5_9:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Martyna Krzykawska-Serda 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 754 176 PLN

Project start date (Y-m-d): 2019-10-01

Project end date (Y-m-d): 2024-03-31

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (20)
  • Book publications / chapters in book publications (1)
  1. Interactions of a Water-Soluble Glycofullerene with Glucose Transporter 1. Analysis of the Cellular Effects on a Pancreatic Tumor Model.
    Authors:
    Edyta Barańska, Olga Wiecheć-Cudak, Monika Rak, Aleksandra Bienia, Anna Mrozek-Wilczkiewicz, Martyna Krzykawska-Serda#, Maciej Serda
    Academic press:
    Nanomaterials (rok: 2021, tom: 11, strony: 46035), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano11020513 - link to the publication
  2. Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors
    Authors:
    Gabriela Dziurman, Agnieszka Drzał, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
    Academic press:
    Mol Imaging Biol (rok: 2023, ), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11307-023-01859-w - link to the publication
  3. Oxygen therapeutic window induced by myo- inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors
    Authors:
    Martyna Krzykawska-Serda, Dariusz Szczygieł, Szymon Gaweł, Agnieszka Drzał, Małgorzata Szczygieł, Maciej M Kmieć, Andrzej Mackiewicz, Claudine Kieda, Martyna Elas
    Academic press:
    Plos one (rok: 2023, tom: 18, strony: e0285318), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0285318 - link to the publication
  4. Photodynamic therapy and hyperthermia in combination treatment—Neglected forces in the fight against cancer.
    Authors:
    A. Bienia, O. Wiecheć-Cudak, A. A. Murzyn, M. Krzykawska-Serda
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1147-), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13081147 - link to the publication
  1. Optimization of CW and Pulse EPR measurements of OxyChip probes to noninvasive measurements of tissue hypoxia
    Authors:
    Gabriela Dziurman, Aleksandra Anna Murzyn, Agnieszka Drzał, Martyna Krzykawska-Serda, Martyna Elas
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  2. Biodistribution of a gold nanoparticle-based construct in a mouse model of pancreatic ductal adenocarcinoma (PDAC)
    Authors:
    Aleksandra Anna Murzyn, Anna Kozińska, Rafał Sitko, Karina Kocot, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  3. IMMUNOCOMPETENT AND RPRODUCTABLE MOUSE MODEL OF ORTHOTOPIC PANCREATIC CANCER
    Authors:
    A.A. Murzyn, M. Szczygieł, D. Szczygieł, M. Krzykawska-Serda
    Conference:
    WinterSchool 2022: Omics research – from methodology to application (rok: 2022, ), Wydawca: WBBiB UJ
    Data:
    konferencja 22-24 lutego
    Status:
    Published
  4. Normoxic and hypoxic spheroids of pancreatic ductal adenocarcinoma (PDAC) – environment oxygenation as a driven factor of invasiveness and proliferation
    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Sylwia Drabik, Dominik Robak, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  5. The novel gold nanorod-based nanotherapeutic for multimodule pancreatic cancer therapy
    Authors:
    A. Bienia, A. Murzyn, M. Szczygieł, D. Szczygieł, O. Wiecheć-Cudak, D. Robak, R. Sitko, M. Zubko, A. Kozińska, M. Serda, M. Krzykawska-Serda
    Conference:
    48th Winter School (From proton to proteome) WBBiB UJ (rok: 2021, ), Wydawca: Jagiellonian University
    Data:
    konferencja 11-13.02.2021
    Status:
    Published
  6. Multi-module pancreatic cancer therapy with the novel gold nanorod-based nanotherapeutic
    Authors:
    Aleksandra Bienia, Aleksandra Anna Murzyn, Małgorzata Szczygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    X Jubileuszowe Konwersatorium Chemii Medycznej w Lublinie (rok: 2021, ), Wydawca: PTCHM
    Data:
    konferencja 3-5 września 2021
    Status:
    Published
  7. PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) IN MULTI-MODULE THERAPY BASED ON GEMCITABINE WITH HYPERTHERMIA IN COMBINATION WITH GOLD NANORODS OR CALCITRIOL
    Authors:
    O. Wiecheć-Cudak, A. Bienia, A. Murzyn, D. Robak, M. Szczygieł, D. Szczygieł, A. Kozińska, R. Sitko, M. Zubko, M. Serda, M. Krzykawska-Serda
    Conference:
    WinterSchool 2022: Omics research – from methodology to application (rok: 2022, ), Wydawca: WBBiB UJ
    Data:
    konferencja 22-24 lutego
    Status:
    Published
  8. Combined chemotherapy with hyperthermia and calcitriol in immunocompetent and orthotopic pancreatic tumor mouse models
    Authors:
    Olga Wiecheć-Cudak, Aleksandra Murzyn, Dariusz Szczygieł, Iga Łakoma, Mariia Oliinyk, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  9. Novel theranostics nanoconjugate based on gold nanorods in multi-module therapy - in vitro studies on pancreatic ductal adenocarcinoma (PDAC)
    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Dominik Robak, Olga Wiecheć-Cudak, Małgorzata Szczygieł, Dariusz Szczygieł, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    The 8th Conference of Polish Metabolomic Society Metabolomics Circle 2021 (rok: 2021, ), Wydawca: University of Silesia
    Data:
    konferencja 19.11.2021
    Status:
    Published
  10. ONCO-058 – Oxygenation of orthotopic pancreatic tumors during multimodal therapy in vivo
    Authors:
    Aleksandra A. Murzyn, Olga Wiecheć-Cudak, Gabriela Dziurman, Aleksandra A. Bienia, Agnieszka Drzał, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EMIM 2024 (rok: 2024, ), Wydawca: European Society for Molecular Imaging
    Data:
    konferencja 12-15.03.2024
    Status:
    Published
  11. ONCO-117 – Non-invasive oxygen mapping in preclinical tumors
    Authors:
    Aleksandra A. Murzyn, Aleksandra A. Bienia, Gabriela Dziurman, Agnieszka Drzał, Dariusz Szczygieł, Martyna Krzykawska-Serda, Małgorzata Szczygieł, Martyna Elas
    Conference:
    EMIM2024 (rok: 2024, ), Wydawca: European Society for Molecular Imaging
    Data:
    konferencja 12-15.03.2024
    Status:
    Published
  12. Gold nanorods as a component of multi-module therapy in the treatment of pancreatic adenocarcinoma (PDAC)
    Authors:
    Aleksandra Anna Murzyn, Aleksandra Bienia, Małgorzata Szczygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    3rd International Workshop on Functional Nanostructured Materials 3 (FuNaM-3) (rok: 2021, ), Wydawca: Jagiellonian University
    Data:
    konferencja October 6th – 8th, 2021
    Status:
    Published
  13. Multi-module treatment against pancreatic cancer – synergetic effects of nanogold, gemcitabine, and hyperthermia on cancer cells
    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Małgorzata Szygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Rafał Sitko, Maciej Zubko, Mateusz Dulski, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  14. Development of a Convolutional Neural Network (CNN) model for automated cell counting and classification in transmitted light microscopy images of cancer cell lines
    Authors:
    Dominik Robak, Piotr Kluska, Aleksandra Bienia, Mirosław Zarębski, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (rok: 2023, ), Wydawca: Jagiellonian University
    Data:
    konferencja 22-24 luty 2023
    Status:
    Published
  15. Oxygen partial pressure dynamic as a marker of chemotherapy efficiency – in vivo study on OchyChip and murine pancreatic cancer
    Authors:
    G. Dziurman G, A. Drzał, A.A. Murzyn, M.M. Kmiec, M. Krzykawska-Serda, M. Elas
    Conference:
    EPR 2023 - International Conference on EPR Spectroscopy and Imaging of Biological Systems (rok: 2023, ), Wydawca: Paris University, France
    Data:
    konferencja 22-26 maj 2023
    Status:
    Published
  16. ONCO-002 – Oxygen measurement as a tool to monitor tumor response after multi-modality-treatment
    Authors:
    Aleksandra A. Murzyn, Maciej Serda, Gabriela Dziurman, Agnieszka Drzał, Maciej Kmieć, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EMIM 2024 (rok: 2024, ), Wydawca: European Society for Molecular Imaging
    Data:
    konferencja 12-15.03.2024
    Status:
    Published
  17. Combined chemotherapy with hyperthermia and calcitriol in pancreatic tumor models
    Authors:
    Olga Wiecheć-Cudak, Aleksandra Murzyn, Dariusz Szczygieł, Iga Łakoma, Mariia Oliinyk, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EACR 2023 (rok: 2023, ), Wydawca: European Association for Cancer Research
    Status:
    Accepted for publication
  18. Design, Synthesis, and Evaluation of Novel Gold Nanorod-Based Theranostic Agents for Anticancer Therapy #474
    Authors:
    Aleksandra Murzyn, Olga Wiecheć-Cudak, Gabriela Dziurman, Drwięga Gniewosz, Agnieszka Drzał, Małgorzata Szczygieł, Piotr Świerzewski, Martyna Elas, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    JS2024 : 5th Jagiellonian Symposium on Advances in Particle Physics and Medicine (rok: 2024, ), Wydawca: Jagiellonian University
    Status:
    Accepted for publication
  19. Advanced Gold Nanorod-Based Theranostics: A Multimodal Approach to Combat Pancreatic Ductal Adenocarcinoma
    Authors:
    Krzykawska-Serda Martyna, Murzyn Aleksandra, Bienia Aleksandra, Wiecheć-Cudak Olga, Dziurman Gabriela, Drwięga Gniewosz, Drzał Agnieszka, Szczygieł Małgorzata, Świerzewski Piotr, Serda Maciej , Elas Martyna
    Conference:
    Chemistry towards Biology 2024 (rok: 2024, ), Wydawca: Jagiellonian University
    Status:
    Accepted for publication
  20. Tumor oxygenation dynamics in murine orthotopic pancreatic cancer: insights from in vivo multimodal therapy
    Authors:
    Martyna Krzykawska-Serda, Aleksandra A. Murzyn, Gabriela A. Dziurman, Aleksandra A. Bienia, Agnieszka E. Drzał, Olga M. Wiecheć-Cudak, Maciej M. Serda and Martyna Elas
    Conference:
    63rd Rocky Mountain Conference on Magnetic Resonance, 45th International EPR Symposium (rok: 2024, ), Wydawca: Colorado Section – American Chemical Society↗︎ and the Society for Applied Spectroscopy
    Status:
    Accepted for publication
  1. Electron Paramagnetic Resonance Imaging-Solo and Orchestra
    Authors:
    Martyna Elas, Martyna Krzykawska-Serda, Michał Gonet, Anna Kozińska, Przemysław M. Płonka
    Book:
    Medical Imaging Methods (rok: 2019, tom: 1, strony: 15342), Wydawca: Springer
    Status:
    Published

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