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Hypoxia in combinatory treatment of murine pancreatic tumor

2018/29/B/NZ5/02954

Keywords

Descriptors

  • NZ1_3: Biofizyka
  • NZ4_12: Inne zagadnienia pokrewne
  • NZ5_9: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Martyna Krzykawska-Serda

Number of co-investigators in the project: 5

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
1 754 176 PLN
Project start date
2019-10-01
Project end date
2024-03-31
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

  1. Oxygen therapeutic window induced by myo- inositol trispyrophosphate (ITPP)–Local pO2 study in murine tumors

    Authors:
    Martyna Krzykawska-Serda, Dariusz Szczygieł, Szymon Gaweł, Agnieszka Drzał, Małgorzata Szczygieł, Maciej M Kmieć, Andrzej Mackiewicz, Claudine Kieda, Martyna Elas
    Academic press:
    Plos one (year: 2023, volume: 18, pages: e0285318), Publisher: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0285318 – link to the publication

  2. Photodynamic therapy and hyperthermia in combination treatment—Neglected forces in the fight against cancer.

    Authors:
    A. Bienia, O. Wiecheć-Cudak, A. A. Murzyn, M. Krzykawska-Serda
    Academic press:
    Pharmaceutics (year: 2021, volume: 13, pages: 1147-), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13081147 – link to the publication

  3. Interactions of a Water-Soluble Glycofullerene with Glucose Transporter 1. Analysis of the Cellular Effects on a Pancreatic Tumor Model.

    Authors:
    Edyta Barańska, Olga Wiecheć-Cudak, Monika Rak, Aleksandra Bienia, Anna Mrozek-Wilczkiewicz, Martyna Krzykawska-Serda#, Maciej Serda
    Academic press:
    Nanomaterials (year: 2021, volume: 11, pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nano11020513 – link to the publication

  4. Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors

    Authors:
    Gabriela Dziurman, Agnieszka Drzał, Aleksandra Anna Murzyn, Maciej Mikolaj Kmiec, Martyna Elas, Martyna Krzykawska-Serda
    Academic press:
    Mol Imaging Biol (year: 2023, volume: 0, pages: 46033), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11307-023-01859-w – link to the publication

Articles in post-conference publications (20)

  1. Multi-module treatment against pancreatic cancer – synergetic effects of nanogold, gemcitabine, and hyperthermia on cancer cells

    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Małgorzata Szygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Rafał Sitko, Maciej Zubko, Mateusz Dulski, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 51), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  2. Optimization of CW and Pulse EPR measurements of OxyChip probes to noninvasive measurements of tissue hypoxia

    Authors:
    Gabriela Dziurman, Aleksandra Anna Murzyn, Agnieszka Drzał, Martyna Krzykawska-Serda, Martyna Elas
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 56), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  3. Biodistribution of a gold nanoparticle-based construct in a mouse model of pancreatic ductal adenocarcinoma (PDAC)

    Authors:
    Aleksandra Anna Murzyn, Anna Kozińska, Rafał Sitko, Karina Kocot, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 62), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  4. PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) IN MULTI-MODULE THERAPY BASED ON GEMCITABINE WITH HYPERTHERMIA IN COMBINATION WITH GOLD NANORODS OR CALCITRIOL

    Authors:
    O. Wiecheć-Cudak, A. Bienia, A. Murzyn, D. Robak, M. Szczygieł, D. Szczygieł, A. Kozińska, R. Sitko, M. Zubko, M. Serda, M. Krzykawska-Serda
    Conference:
    WinterSchool 2022: Omics research – from methodology to application (year: 2022, pages: 115), Publisher: WBBiB UJ
    Date:
    conference 22-24 lutego
    Status:
    Published

  5. IMMUNOCOMPETENT AND RPRODUCTABLE MOUSE MODEL OF ORTHOTOPIC PANCREATIC CANCER

    Authors:
    A.A. Murzyn, M. Szczygieł, D. Szczygieł, M. Krzykawska-Serda
    Conference:
    WinterSchool 2022: Omics research – from methodology to application (year: 2022, pages: 131), Publisher: WBBiB UJ
    Date:
    conference 22-24 lutego
    Status:
    Published

  6. Normoxic and hypoxic spheroids of pancreatic ductal adenocarcinoma (PDAC) – environment oxygenation as a driven factor of invasiveness and proliferation

    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Sylwia Drabik, Dominik Robak, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 50), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  7. Development of a Convolutional Neural Network (CNN) model for automated cell counting and classification in transmitted light microscopy images of cancer cell lines

    Authors:
    Dominik Robak, Piotr Kluska, Aleksandra Bienia, Mirosław Zarębski, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 66), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  8. Oxygen partial pressure dynamic as a marker of chemotherapy efficiency – in vivo study on OchyChip and murine pancreatic cancer

    Authors:
    G. Dziurman G, A. Drzał, A.A. Murzyn, M.M. Kmiec, M. Krzykawska-Serda, M. Elas
    Conference:
    EPR 2023 - International Conference on EPR Spectroscopy and Imaging of Biological Systems (year: 2023, pages: 58), Publisher: Paris University, France
    Date:
    conference 22-26 maj 2023
    Status:
    Published

  9. Combined chemotherapy with hyperthermia and calcitriol in immunocompetent and orthotopic pancreatic tumor mouse models

    Authors:
    Olga Wiecheć-Cudak, Aleksandra Murzyn, Dariusz Szczygieł, Iga Łakoma, Mariia Oliinyk, Martyna Krzykawska-Serda
    Conference:
    50th Winter School, MOLECULES ACTING IN CANCER BIOLOGY AND THERAPY (year: 2023, pages: 76), Publisher: Jagiellonian University
    Date:
    conference 22-24 luty 2023
    Status:
    Published

  10. The novel gold nanorod-based nanotherapeutic for multimodule pancreatic cancer therapy

    Authors:
    A. Bienia, A. Murzyn, M. Szczygieł, D. Szczygieł, O. Wiecheć-Cudak, D. Robak, R. Sitko, M. Zubko, A. Kozińska, M. Serda, M. Krzykawska-Serda
    Conference:
    48th Winter School (From proton to proteome) WBBiB UJ (year: 2021, pages: 46 and 42 and 86), Publisher: Jagiellonian University
    Date:
    conference 11-13.02.2021
    Status:
    Published

  11. Novel theranostics nanoconjugate based on gold nanorods in multi-module therapy - in vitro studies on pancreatic ductal adenocarcinoma (PDAC)

    Authors:
    Aleksandra Bienia, Aleksandra Murzyn, Dominik Robak, Olga Wiecheć-Cudak, Małgorzata Szczygieł, Dariusz Szczygieł, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    The 8th Conference of Polish Metabolomic Society Metabolomics Circle 2021 (year: 2021, pages: 31), Publisher: University of Silesia
    Date:
    conference 19.11.2021
    Status:
    Published

  12. ONCO-058 – Oxygenation of orthotopic pancreatic tumors during multimodal therapy in vivo

    Authors:
    Aleksandra A. Murzyn, Olga Wiecheć-Cudak, Gabriela Dziurman, Aleksandra A. Bienia, Agnieszka Drzał, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EMIM 2024 (year: 2024, pages: ONCO-058), Publisher: European Society for Molecular Imaging
    Date:
    conference 12-15.03.2024
    Status:
    Published

  13. ONCO-002 – Oxygen measurement as a tool to monitor tumor response after multi-modality-treatment

    Authors:
    Aleksandra A. Murzyn, Maciej Serda, Gabriela Dziurman, Agnieszka Drzał, Maciej Kmieć, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EMIM 2024 (year: 2024, pages: ONCO-002), Publisher: European Society for Molecular Imaging
    Date:
    conference 12-15.03.2024
    Status:
    Published

  14. ONCO-117 – Non-invasive oxygen mapping in preclinical tumors

    Authors:
    Aleksandra A. Murzyn, Aleksandra A. Bienia, Gabriela Dziurman, Agnieszka Drzał, Dariusz Szczygieł, Martyna Krzykawska-Serda, Małgorzata Szczygieł, Martyna Elas
    Conference:
    EMIM2024 (year: 2024, pages: ONCO-117), Publisher: European Society for Molecular Imaging
    Date:
    conference 12-15.03.2024
    Status:
    Published

  15. Multi-module pancreatic cancer therapy with the novel gold nanorod-based nanotherapeutic

    Authors:
    Aleksandra Bienia, Aleksandra Anna Murzyn, Małgorzata Szczygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    X Jubileuszowe Konwersatorium Chemii Medycznej w Lublinie (year: 2021, pages: C15), Publisher: PTCHM
    Date:
    conference 3-5 września 2021
    Status:
    Published

  16. Gold nanorods as a component of multi-module therapy in the treatment of pancreatic adenocarcinoma (PDAC)

    Authors:
    Aleksandra Anna Murzyn, Aleksandra Bienia, Małgorzata Szczygieł, Dariusz Szczygieł, Olga Wiecheć-Cudak, Dominik Robak, Anna Kozińska, Rafał Sitko, Maciej Zubko, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    3rd International Workshop on Functional Nanostructured Materials 3 (FuNaM-3) (year: 2021, pages: 98), Publisher: Jagiellonian University
    Date:
    conference October 6th – 8th, 2021
    Status:
    Published

  17. Combined chemotherapy with hyperthermia and calcitriol in pancreatic tumor models

    Authors:
    Olga Wiecheć-Cudak, Aleksandra Murzyn, Dariusz Szczygieł, Iga Łakoma, Mariia Oliinyk, Martyna Elas, Martyna Krzykawska-Serda
    Conference:
    EACR 2023 (year: 2023, pages: 1), Publisher: European Association for Cancer Research
    Status:
    Accepted for publication

  18. Design, Synthesis, and Evaluation of Novel Gold Nanorod-Based Theranostic Agents for Anticancer Therapy #474

    Authors:
    Aleksandra Murzyn, Olga Wiecheć-Cudak, Gabriela Dziurman, Drwięga Gniewosz, Agnieszka Drzał, Małgorzata Szczygieł, Piotr Świerzewski, Martyna Elas, Maciej Serda, Martyna Krzykawska-Serda
    Conference:
    JS2024 : 5th Jagiellonian Symposium on Advances in Particle Physics and Medicine (year: 2024, pages: 46024), Publisher: Jagiellonian University
    Status:
    Accepted for publication

  19. Advanced Gold Nanorod-Based Theranostics: A Multimodal Approach to Combat Pancreatic Ductal Adenocarcinoma

    Authors:
    Krzykawska-Serda Martyna, Murzyn Aleksandra, Bienia Aleksandra, Wiecheć-Cudak Olga, Dziurman Gabriela, Drwięga Gniewosz, Drzał Agnieszka, Szczygieł Małgorzata, Świerzewski Piotr, Serda Maciej , Elas Martyna
    Conference:
    Chemistry towards Biology 2024 (year: 2024, pages: 46024), Publisher: Jagiellonian University
    Status:
    Accepted for publication

  20. Tumor oxygenation dynamics in murine orthotopic pancreatic cancer: insights from in vivo multimodal therapy

    Authors:
    Martyna Krzykawska-Serda, Aleksandra A. Murzyn, Gabriela A. Dziurman, Aleksandra A. Bienia, Agnieszka E. Drzał, Olga M. Wiecheć-Cudak, Maciej M. Serda and Martyna Elas
    Conference:
    63rd Rocky Mountain Conference on Magnetic Resonance, 45th International EPR Symposium (year: 2024, pages: 1), Publisher: Colorado Section – American Chemical Society↗︎ and the Society for Applied Spectroscopy
    Status:
    Accepted for publication

Book publications / chapters in book publications (1)

  1. Electron Paramagnetic Resonance Imaging-Solo and Orchestra

    Authors:
    Martyna Elas, Martyna Krzykawska-Serda, Michał Gonet, Anna Kozińska, Przemysław M. Płonka
    Book:
    Medical Imaging Methods (year: 2019, volume: 1, pages: 15342), Publisher: Springer
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski