Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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How platelet microparticles affect invasiveness of colon cancer cells in the process of metastasis. Can we change it?

2018/29/B/NZ5/01756

Keywords:

Platelet microparticles cell invasion metastasis colon cancer

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Kowalska 

Number of co-investigators in the project: 4

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 482 313 PLN

Project start date (Y-m-d): 2019-01-24

Project end date (Y-m-d): 2023-07-23

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wielofunkcyjny czytnik płytkowy (286 713 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Snail Overexpression Alters the microRNA Content of Extracellular Vesicles Released from HT29 Colorectal Cancer Cells and Activates Pro-Inflammatory State In Vivo
    Authors:
    Izabela Papiewska-Pająk, Patrycja Przygodzka, Damian Krzyżanowski, Kamila Soboska, Izabela Szulc-Kiełbik, Olga Stasikowska-Kanicka, Joanna Boncela, Małgorzata Wągrowska-Danilewicz, and M. Anna Kowalska
    Academic press:
    Cancers (Basel). (rok: 2021, tom: 13(2), strony: 172-187), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13020172 - link to the publication
  2. Platelet-derived microparticles stimulate the invasiveness of colorectal cancer cells via the p38MAPK-MMP-2/MMP-9 axis
    Authors:
    Hassan Kassassir, Izabela Papiewska-Pająk, Jakub Kryczka, Joanna Boncela, M Anna Kowalska
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21(1), strony: 51-63), Wydawca: BioMed Central, Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-023-01066-8 - link to the publication
  3. Glypican-1 Level Is Elevated in Extracellular Vesicles Released from MC38 Colon Adenocarcinoma Cells Overexpressing Snail
    Authors:
    Izabela Papiewska-Pająk, Damian Krzyżanowski, Maria Katela, Romain Rivet, Sylwia Michlewska, Patrycja Przygodzka, M. Anna Kowalska, and Stéphane Brézillon
    Academic press:
    Cells (rok: 2020, tom: 9(7), strony: 1585-1596), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071585 - link to the publication
  1. Changes of miRNA profile in extracellular vesicles released by colorectal cancer cells during early EMT
    Authors:
    Izabela Papiewska-Pająk, Damian Krzyżanowski, Patrycja Przygodzka, Joanna Boncela, M. Anna Kowalska
    Conference:
    Konferencja ISEV2020 (rok: 2020, ), Wydawca: Philadelphia, USA
    Data:
    konferencja 20-22 lipca
    Status:
    Published
  2. Increased expression of chemokine receptor CXCR4 in non-invasive colorectal cancer cells after incorporation of platelet-derived extracellular vesicles.
    Authors:
    Izabela Papiewska-Pajak, Hassan Kassassir, Damian Krzyzanowski, Jakub Kryczka, M. Anna Kowalsk
    Conference:
    Konferencja ISEV2020 (rok: 2020, ), Wydawca: ISEV
    Data:
    konferencja 20-22 lipca
    Status:
    Published
  3. Glypican-1 expression is elevated in colon adenocarcinoma extracellular vesicles of MC38 cells overexpressing SNAIL
    Authors:
    Izabela Papiewska-Pajak, Damian Krzyżanowski, Maria Catella, Romain Rivet, Sylwia Michlewska, Patrycja Przygodzka, M. Anna Kowalska, Stéphane Brézillon:
    Conference:
    Extracellular Vesicles in Health & Disease FSEV-2019 Congress (rok: 2019, ), Wydawca: Nantes, Francja
    Data:
    konferencja 14-15 października
    Status:
    Published
  4. "Can the platelet-derived extracellular vesicles change invasiveness of colorectal cancer cells by transferring the chemokine receptor 4?"
    Authors:
    H. Kassassir, I. Papiewska-Pajak, J. Kryczka, M.A. Kowalska
    Conference:
    Conference of International Society of Extracellular Vesicles 2021 (rok: 2021, ), Wydawca: Virtual Conference
    Data:
    konferencja 18-21 May
    Status:
    Published

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