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Integrated transcriptomic, proteomic and metabolomic analysis of molecules that mediate homing of mesenchymal stem cells to renal cancer

2018/29/B/NZ5/01211

Keywords

Descriptors

  • NZ5_9: Inne zagadnienia pokrewne
  • NZ2_4: Metabolomika
  • NZ2_3: Proteomika

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Agnieszka Piekiełko-Witkowska

Number of co-investigators in the project: 12

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
1 836 395 PLN
Project start date
2019-02-13
Project end date
2024-02-12
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (6)

  1. Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration

    Authors:
    Poplawski P, Alseekh S, Jankowska U, Skupien-Rabian B, Iwanicka-Nowicka R, Kossowska H, Fogtman A, Rybicka B, Bogusławska J, Adamiok-Ostrowska A, Hanusek K, Hanusek J, Koblowska M, Fernie AR, Piekiełko-Witkowska A.
    Academic press:
    Cancer Cell International (year: 2023, volume: 23, pages: 46037), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s12935-022-02845-y – link to the publication

  2. Renal cancer secretome induces migration of mesenchymal stromal cells.

    Authors:
    Popławski P, Zarychta-Wiśniewska W, Burdzińska A, Bogusławska J, Adamiok-Ostrowska A, Hanusek K, Rybicka B, Białas A, Kossowska H, Iwanicka-Rokicka R, Koblowska M, Pączek L, Piekiełko-Witkowska A.
    Academic press:
    Stem cell research and therapy (year: 2023, volume: 14(1), pages: 200), Publisher: BMC
    Status:
    Published
    DOI:
    10.1186/s13287-023-03430-4 – link to the publication

  3. TGF‑β1 affects the renal cancer miRNome and regulates tumor cells proliferation

    Authors:
    Karolina Hanusek, Beata Rybicka, Piotr Popławski, Anna Adamiok-Ostrowska, Katarzyna Głuchowska, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Academic press:
    International Journal of Molecular Medicine (year: 2022, volume: 49,4, pages: 46036), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijmm.2022.5108 – link to the publication

  4. Ciliary Genes in Renal Cystic Diseases

    Authors:
    Anna Adamiok-Ostrowska, Agnieszka Piekiełko-Witkowska
    Academic press:
    Cells (year: 2020, volume: 9, pages: 907), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9040907 – link to the publication

  5. piRNAs and PIWI Proteins as Diagnostic and Prognostic Markers of Genitourinary Cancers

    Authors:
    Karolina Hanusek, Sławomir Poletajew, Piotr Kryst, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Academic press:
    Biomolecules (year: 2022, volume: 12, 186, pages: 46047), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12020186 – link to the publication

  6. Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells

    Authors:
    Joanna Bogusławska, Małgorzata Grzanka, Piotr Popławski, Weronika Zarychta-Wiśniewska, Anna Burdzinska, Karolina Hanusek, Helena Kossowska, Roksana Iwanicka-Nowicka, Alex Białas, Beata Rybicka, Anna Adamiok-Ostrowska, Joanna Życka-Krzesińska, Marta Koblowska, Leszek Pączek & Agnieszka Piekiełko-Witkowska
    Academic press:
    Cell Communication and Signaling (year: 2025, volume: 23, pages: 46035), Publisher: Springer Nature BMC
    Status:
    Published
    DOI:
    10.1186/s12964-024-02001-1 – link to the publication

Articles in post-conference publications (10)

  1. Leptin secreted by tumour -associated adipose tissue regulates miR-199a-DDR1 axis in renal cancer

    Authors:
    Anna Litwiniuk, Małgorzata Kalisz, Piotr Kryst, Sławomir Poletajew, Beata Rybicka, Wojciech Bik, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Conference:
    27th Congress of The European Association For Cancer Research (year: 2021, pages: nie dotyczy), Publisher: EACR
    Date:
    conference 9-12 czerwca 2021
    Status:
    Published

  2. Global omics analysis reveals TP53 as a top regulator of renal cancer secretome

    Authors:
    Piotr Popławski , Helena Kossowska, Bożena Skupień-Rabian , Urszula Jankowska, Roksana Iwanicka-Nowicka, Beata Rybicka, Marta Koblowska, Agnieszka Piekiełko-Witkowska
    Conference:
    27th Congress of The European Association For Cancer Research, 09-12 June 2021 (year: 2021, pages: nie dotyczy), Publisher: EACR
    Date:
    conference 9-12 czerwca 2021
    Status:
    Published

  3. Transfection of human mesenchymal stromal cells with piR-004153 leads to downregulation of FGF2, SLC7A5 and WISP1 expression

    Authors:
    Bogusławska J, Kossowska H, Iwanicka-Rokicka R, Popławski P, Białas A, Zarychta-Wiśniewska W, Burdzińska A, Pączek L, Koblowska M, Piekiełko-Witkowska A
    Conference:
    The 7th Warsaw conference on Perspectives of Molecular Oncology (year: 2022, pages: 19-20), Publisher: NIO-PIB
    Date:
    conference 2022.10.06-2022.10.07
    Status:
    Published

  4. The influence of renal cell carcinoma secretome on recruitment of mesenchymal stromal cells

    Authors:
    Piotr Popławski, Weronika Zarychta-Wiśniewska, Barbara Skupień-Raban, Urszula Jankowska, Beata Rybicka, Anna Burdzińska, Leszek Pączek, Agnieszka Piekiełko-Witkowska
    Conference:
    27th Congress of The European Association For Cancer Research (year: 2021, pages: nie dotyczy), Publisher: EACR
    Date:
    conference 9-12 czerwca 2021
    Status:
    Published

  5. The expression of genes associated with piRNAs biosynthesis and action is disturbed in renal cancer

    Authors:
    Karolina Hanusek, Joanna Bogusławska, Jan Hanusek, Agnieszka Piekiełko-Witkowska
    Conference:
    EMBO Workshop on PIWI Proteins and piRNAs (year: 2022, pages: 28), Publisher: EMBO
    Date:
    conference 2022.04.06-2022.04.09
    Status:
    Published

  6. Renal cancer cells stimulate migration of MSC cells via secretion of piR-004153

    Authors:
    Joanna Bogusławska, Piotr Popławski, Beata Rybicka, Anna Adamiok-Ostrowska, Weronika Zarychta-Wiśniewska, Anna Burdzińska, Leszek Pączek, Agnieszka Piekiełko-Witkowska
    Conference:
    EMBO Workshop on PIWI Proteins and piRNAs (year: 2022, pages: 39), Publisher: EMBO
    Date:
    conference 2022.04.06-2022.04.09
    Status:
    Published

  7. RNAseq analysis of exosomal miRNAs secreted by renal cancer cells

    Authors:
    Piotr Popławski, Joanna Bogusławska, Beata Rybicka, Agnieszka Piekiełko-Witkowska
    Conference:
    The 5 th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer (year: 2020, pages: nienumerowane), Publisher: Narodowy Instytut Onkologii
    Date:
    conference 23-24 września 2020
    Status:
    Published

  8. Impact of hypothyroidism on early preneoplastic changes at the transcriptomic level in mammalian cells

    Authors:
    Karolina Hanusek, Monika Duda, Agnieszka Piekiełko-Witkowska
    Conference:
    22nd European Congress of Endocrinology (year: 2020, pages: nienumerowane), Publisher: Bioscientifica
    Date:
    conference 5-9 września 2020
    Status:
    Published

  9. Conditioned media from renal cancer cells reprogram transcriptome of MSC cells: possible role of microRNAs

    Authors:
    J. Bogusławska, H. Kossowska, R. Iwanicka-Nowicka, P. Popławski, K. Hanusek, B. Rybicka, W. Zarychta-Wiśniewska, A. Burdzińska, M. Koblowska, L. Pączek, A. Piekiełko-Witkowska
    Conference:
    EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine (year: 2022, pages: 1), Publisher: EACR
    Date:
    conference 2022.06.22-2022.06.23
    Status:
    Published

  10. lncRNAs mediate the action of TGF-β1 in renal cell carcinoma of the clear cell type (ccRCC)

    Authors:
    Anna Adamiok-Ostrowska, Beata Rybicka, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Conference:
    27th Congress of The European Association For Cancer Research, 09-12 June 2021 (year: 2021, pages: nie dotyczy), Publisher: EACR
    Date:
    conference 9-12 czerwca 2021
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski