Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Integrated transcriptomic, proteomic and metabolomic analysis of molecules that mediate homing of mesenchymal stem cells to renal cancer

2018/29/B/NZ5/01211

Keywords:

mesenchymal stem (stromal) cells renal cancer microRNA non-coding RNA transcriptome proteome metabolome cytokines chemokines metabolome secretome

Descriptors:

  • NZ5_9: Other related subjects
  • NZ2_4: Metabolomics
  • NZ2_3: Proteomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Piekiełko-Witkowska 

Number of co-investigators in the project: 12

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 836 395 PLN

Project start date (Y-m-d): 2019-02-13

Project end date (Y-m-d): 2024-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (10)
  1. Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration
    Authors:
    Poplawski P, Alseekh S, Jankowska U, Skupien-Rabian B, Iwanicka-Nowicka R, Kossowska H, Fogtman A, Rybicka B, Bogusławska J, Adamiok-Ostrowska A, Hanusek K, Hanusek J, Koblowska M, Fernie AR, Piekiełko-Witkowska A.
    Academic press:
    Cancer Cell International (rok: 2023, tom: 23, strony: 45306), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12935-022-02845-y - link to the publication
  2. Ciliary Genes in Renal Cystic Diseases
    Authors:
    Anna Adamiok-Ostrowska, Agnieszka Piekiełko-Witkowska
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 907), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9040907 - link to the publication
  3. piRNAs and PIWI Proteins as Diagnostic and Prognostic Markers of Genitourinary Cancers
    Authors:
    Karolina Hanusek, Sławomir Poletajew, Piotr Kryst, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Academic press:
    Biomolecules (rok: 2022, tom: 12, 186, strony: 45316), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12020186 - link to the publication
  4. TGF‑β1 affects the renal cancer miRNome and regulates tumor cells proliferation
    Authors:
    Karolina Hanusek, Beata Rybicka, Piotr Popławski, Anna Adamiok-Ostrowska, Katarzyna Głuchowska, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Academic press:
    International Journal of Molecular Medicine (rok: 2022, tom: 49,4, strony: 45305), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijmm.2022.5108 - link to the publication
  1. lncRNAs mediate the action of TGF-β1 in renal cell carcinoma of the clear cell type (ccRCC)
    Authors:
    Anna Adamiok-Ostrowska, Beata Rybicka, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Conference:
    27th Congress of The European Association For Cancer Research, 09-12 June 2021 (rok: 2021, ), Wydawca: EACR
    Data:
    konferencja 9-12 czerwca 2021
    Status:
    Published
  2. Impact of hypothyroidism on early preneoplastic changes at the transcriptomic level in mammalian cells
    Authors:
    Karolina Hanusek, Monika Duda, Agnieszka Piekiełko-Witkowska
    Conference:
    22nd European Congress of Endocrinology (rok: 2020, ), Wydawca: Bioscientifica
    Data:
    konferencja 5-9 września 2020
    Status:
    Published
  3. Renal cancer cells stimulate migration of MSC cells via secretion of piR-004153
    Authors:
    Joanna Bogusławska, Piotr Popławski, Beata Rybicka, Anna Adamiok-Ostrowska, Weronika Zarychta-Wiśniewska, Anna Burdzińska, Leszek Pączek, Agnieszka Piekiełko-Witkowska
    Conference:
    EMBO Workshop on PIWI Proteins and piRNAs (rok: 2022, ), Wydawca: EMBO
    Data:
    konferencja 2022.04.06-2022.04.09
    Status:
    Published
  4. RNAseq analysis of exosomal miRNAs secreted by renal cancer cells
    Authors:
    Piotr Popławski, Joanna Bogusławska, Beata Rybicka, Agnieszka Piekiełko-Witkowska
    Conference:
    The 5 th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer (rok: 2020, ), Wydawca: Narodowy Instytut Onkologii
    Data:
    konferencja 23-24 września 2020
    Status:
    Published
  5. Conditioned media from renal cancer cells reprogram transcriptome of MSC cells: possible role of microRNAs
    Authors:
    J. Bogusławska, H. Kossowska, R. Iwanicka-Nowicka, P. Popławski, K. Hanusek, B. Rybicka, W. Zarychta-Wiśniewska, A. Burdzińska, M. Koblowska, L. Pączek, A. Piekiełko-Witkowska
    Conference:
    EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine (rok: 2022, ), Wydawca: EACR
    Data:
    konferencja 2022.06.22-2022.06.23
    Status:
    Published
  6. Global omics analysis reveals TP53 as a top regulator of renal cancer secretome
    Authors:
    Piotr Popławski , Helena Kossowska, Bożena Skupień-Rabian , Urszula Jankowska, Roksana Iwanicka-Nowicka, Beata Rybicka, Marta Koblowska, Agnieszka Piekiełko-Witkowska
    Conference:
    27th Congress of The European Association For Cancer Research, 09-12 June 2021 (rok: 2021, ), Wydawca: EACR
    Data:
    konferencja 9-12 czerwca 2021
    Status:
    Published
  7. Leptin secreted by tumour -associated adipose tissue regulates miR-199a-DDR1 axis in renal cancer
    Authors:
    Anna Litwiniuk, Małgorzata Kalisz, Piotr Kryst, Sławomir Poletajew, Beata Rybicka, Wojciech Bik, Agnieszka Piekiełko-Witkowska, Joanna Bogusławska
    Conference:
    27th Congress of The European Association For Cancer Research (rok: 2021, ), Wydawca: EACR
    Data:
    konferencja 9-12 czerwca 2021
    Status:
    Published
  8. The expression of genes associated with piRNAs biosynthesis and action is disturbed in renal cancer
    Authors:
    Karolina Hanusek, Joanna Bogusławska, Jan Hanusek, Agnieszka Piekiełko-Witkowska
    Conference:
    EMBO Workshop on PIWI Proteins and piRNAs (rok: 2022, ), Wydawca: EMBO
    Data:
    konferencja 2022.04.06-2022.04.09
    Status:
    Published
  9. The influence of renal cell carcinoma secretome on recruitment of mesenchymal stromal cells
    Authors:
    Piotr Popławski, Weronika Zarychta-Wiśniewska, Barbara Skupień-Raban, Urszula Jankowska, Beata Rybicka, Anna Burdzińska, Leszek Pączek, Agnieszka Piekiełko-Witkowska
    Conference:
    27th Congress of The European Association For Cancer Research (rok: 2021, ), Wydawca: EACR
    Data:
    konferencja 9-12 czerwca 2021
    Status:
    Published
  10. Transfection of human mesenchymal stromal cells with piR-004153 leads to downregulation of FGF2, SLC7A5 and WISP1 expression
    Authors:
    Bogusławska J, Kossowska H, Iwanicka-Rokicka R, Popławski P, Białas A, Zarychta-Wiśniewska W, Burdzińska A, Pączek L, Koblowska M, Piekiełko-Witkowska A
    Conference:
    The 7th Warsaw conference on Perspectives of Molecular Oncology (rok: 2022, ), Wydawca: NIO-PIB
    Data:
    konferencja 2022.10.06-2022.10.07
    Status:
    Published

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