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Significance of transcription factors associated with epithelial-mesenchymal transition and myogenesis in the development of rhabdomyosarcoma

2018/29/B/NZ5/00915

Keywords:

rhabdomyosarcoma iPS cells development EMT myogenesis transcription factors

Descriptors:

  • NZ5_1:
  • NZ5_4:
  • NZ3_8:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Marek Majka 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 2 550 200 PLN

Project start date (Y-m-d): 2019-01-21

Project end date (Y-m-d): 2024-01-20

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Progression and Differentiation of Alveolar Rhabdomyosarcoma Is Regulated by PAX7 Transcription Factor-Significance of Tumor Subclones
    Authors:
    Klaudia Skrzypek, Grażyna Adamek, Marta Kot, Bogna Badyra, Marcin Majka
    Academic press:
    Cells (rok: 2021, tom: 20, strony: 1870), Wydawca: IMPD
    Status:
    Published
    DOI:
    10.3390/cells10081870 - link to the publication
  2. Genome Editing of the SNAI1 Gene in Rhabdomyosarcoma: A Novel Model for Studies of Its Role
    Authors:
    Aleksandra Ulman, Klaudia Skrzypek, Paweł Konieczny, Claudio Mussolino, Toni Cathomen, Marcin Majka
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1095), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9051095 - link to the publication
  3. SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks
    Authors:
    Klaudia Skrzypek, Marta Kot, Paweł Konieczny, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota , Wojciech Bobela, Urszula Jankowska, Sylwia Kedracka-Krok, Marcin Majka
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 1870), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12071870 - link to the publication
  4. Myogenic Differentiation of iPS Cells Shows Different Efficiency in Simultaneous Comparison of Protocols
    Authors:
    Aleksandra Ulman, Marta Kot, Klaudia Skrzypek, Barbara Szewczyk, Marcin Majka
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1671), Wydawca: IMPD
    Status:
    Published
    DOI:
    10.3390/cells10071671 - link to the publication
  5. Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL
    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Bogna Badyra, Małgorzata Lasota, Marcin Majka
    Academic press:
    Mol Ther Nucleic Acids (rok: 2021, tom: 24, strony: 888-904), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2021.04.013 - link to the publication
  6. Myogenic Differentiation of iPS Cells Shows Different Efficiency in Simultaneous Comparison of Protocols
    Authors:
    Aleksandra Ulman, Marta Kot, Klaudia Skrzypek, Barbara Szewczyk, Marcin Majka
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1671), Wydawca: IMPD
    Status:
    Published
    DOI:
    10.3390/cells10071671 - link to the publication

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