Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Hypoxia inducible factor alpha (Hif-1 alpha) and transcription factor Foxn1 guide regenerative vs reparative skin wound healing processes

2017/27/B/NZ5/02610

Keywords:

Foxn1 Hif-1 alpha regeneration skin wound healing

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_4: Pathogenesis of animal diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Barbara Gawrońska-Kozak 

Number of co-investigators in the project: 12

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 994 940 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2023-02-09

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. laptop wraz z oprogramowamiem (Graph Pad Prizm, EndNote) (2 szt.) (15 000 PLN)
  2. Inkubator (52 000 PLN)
  3. Kostka z filtrami do fluorescencji.
  4. Multiskan - czytnik mikropłytek.
  5. Zestaw do analizy metodą Western Blot (15 000 PLN)
  6. zestaw pipet (2 szt.) (7 000 PLN)
  7. Aparat fotograficzny z obiektywem (6 000 PLN)
  8. Countess II - licznik komorek.
  9. System do dekontaminacji inkubatorów.

Information in the final report

  • Publication in academic press/journals (8)
  1. Foxn1 Control of Skin Function
    Authors:
    Gawronska-Kozak Barbara
    Academic press:
    Applied Sciences Basel (rok: 2020, tom: 10, strony: art. no 5685 (1-12)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app10165685 - link to the publication
  2. Molekularne mechanizmy działania czynnika transkrypcyjnego FOXN1 w skórze
    Authors:
    Barbara Gawrońska-Kozak, Anna Kur-Piotrowska, Joanna Wiśniewska, Marta Kopcewicz
    Academic press:
    Postępy HIgieny i Medycyny Doświadczalnej (rok: 2021, tom: 75, strony: 573-583), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/ahem-2021-0028 - link to the publication
  3. The transcription factor Foxn1 regulates skin adipogenesis and affects susceptibility to diet-induced obesity
    Authors:
    Katarzyna Walendzik, Marta Kopcewicz, Joanna Bukowska, Grzegorz Panasiewicz, Bozena Szafranska and Barbara Gawronska-Kozak
    Academic press:
    Journal of Investigative Dermatology (rok: 2020, tom: June; 140 (6), strony: 1166-1175), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jid.2019.11.010 - link to the publication
  4. Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice
    Authors:
    Kopcewicz, M.; Walendzik, K.; Bukowska, J.; Kur-Piotrowska, A.; Machcinska, S.; Gimble, J.M.; Gawronska-Kozak, B
    Academic press:
    Aging-US (rok: 2020, tom: 12, strony: 7066-7111), Wydawca: Albany NY
    Status:
    Published
    DOI:
    10.18632/aging.103064 - link to the publication
  5. Impairment of the Hif-1α regulatory pathway in Foxn1-deficient (Foxn1-/- ) mice affects the skin wound healing process
    Authors:
    Machcinska S, Kopcewicz M, Bukowska J, Walendzik K, Gawronska-Kozak B.
    Academic press:
    FASEB Journal (rok: 2021, tom: 35, strony: 45313), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202001907R - link to the publication
  6. Dermal White Adipose Tissue (dWAT) Is Regulated by Foxn1 and Hif-1 during the Early Phase of Skin Wound Healing
    Authors:
    Barbara Gawronska-Kozak, KatarzynaWalendzik , Sylwia Machcinska , Artur Padzik, Marta Kopcewicz and Joanna Wisniewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 23, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010257 - link to the publication
  7. Hypoxia reveals a new function of Foxn1 in the keratinocyte antioxidant defence system
    Authors:
    Machcinska S., Walendzik K., Kopcewicz M., Wisniewska J., Rokka A., Pääkkönen M., Slowinska M., Gawronska-Kozak B.
    Academic press:
    FASEB Journal (rok: 2022, tom: 36, strony: 45316), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202200249RR - link to the publication
  8. Age, Diet and Epidermal Signaling Modulate Dermal Fibroblasts' Adipogenic Potential
    Authors:
    Katarzyna Walendzik, Joanna Bukowska, Marta Kopcewicz, Sylwia Machcinska, Jeffrey M. Gimble, Barbara Gawronska-Kozak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (23), strony: art. no 8955 (1-19)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21238955 - link to the publication

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