Genetically modified dendritic cells as a component of combined therapy immunomodulating the tumor microenvironment
2017/27/B/NZ6/02702
Keywords
Descriptors
- NZ6_3: Immunologia zwierząt
- NZ5_8: Leczenie chorób zwierząt
- NZ6_5: Wirusologia
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
dr hab. Elżbieta Pajtasz-Piasecka
Number of co-investigators in the project: 6
Call
OPUS 14 – announced on 2017-09-15
- Amount awarded
- 1 153 200 PLN
- Project start date
- 2018-07-31
- Project end date
- 2022-07-30
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- ACEA NovoExpress.
- COMPRO Ms Office.
- Corel.
- GraphPad.
- MORELE Monitor.
- Oprogramowanie do opracowania wyników. Cost: 2 400 PLN
- Sartorius Waga SECURA.
- Zbiornik na ciekły azot do przechowywania materiału biologicznego wraz z wyposażeniem. Cost: 70 000 PLN
- komputer, nagrywarka DVD.
Information in the final report
Publication in academic press/journals (4)
-
The modulation of local and systemic anti-tumor immune response induced by methotrexate nanoconjugate in murine MC38 colon carcinoma and B16 F0 melanoma tumor models has been reviewed
- Authors:
- Agnieszka Szczygieł, Katarzyna Węgierek-Ciura, Jagoda Mierzejewska, Anna Wróblewska, Joanna Rossowska, Natalia Anger-Góra, Bożena Szermer-Olearnik, Marta Świtalska, Tomasz M. Goszczyński, Elżbieta Pajtasz-Piasecka
- Academic press:
- American Journal of Cancer Research (year: 2023, volume: 13(10), pages: -4623-4643), Publisher: e-Century Publishing Corporation
- Status:
- Published
-
Perspektywy zastosowania interleukiny 15 w terapii przeciwnowotworowe
- Authors:
- Katarzyna Węgierek, Elżbieta Pajtasz-Piasecka
- Academic press:
- Postepy Hig Med Dosw (online), 2019; 73: 850–864 (year: 2019, volume: 73, pages: 850–864), Publisher: Index Copernicus
- Status:
- Published
- DOI:
- 10.5604/01.3001.0013.7194 – link to the publication
-
Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines
- Authors:
- Katarzyna We˛ gierek-Ciura*, Jagoda Mierzejewska, Agnieszka Szczygieł, Joanna Rossowska, Anna Wro´ blewska, Marta S´ witalska, Tomasz M. Goszczyn´ ski, Boz˙ena Szermer-Olearnik and Elz˙ bieta Pajtasz-Piasecka
- Academic press:
- Frontiers in Immunology (year: 2023, volume: 14, pages: 1212606), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fimmu.2023.1212606 – link to the publication
-
Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell‑based vaccines in murine colon carcinoma.
- Authors:
- A. Szczygieł, N. Anger‑Góra, K. Węgierek‑Ciura, J. Mierzejewska, J. Rossowska, T. Goszczyński, M. Świtalska, E. Pajtasz‑Piasecka
- Academic press:
- Oncoogy Reports (year: 2021, volume: 45, pages: 945-962), Publisher: Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/or.2021.7930 – link to the publication