Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Preparation and investigation of multifunctional biomaterials based on nanoapatites for possible application in bone tumor treatment.

2017/27/N/ST5/02976

Keywords:

bio-nanoapatites co-doping with alkali metal ions and rare earth ions charge compensation structural-spectroscopy properties surface modification functionalization by chemotherapeutic agents anti-cancer therapy bio-imaging theranostic

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_3: Surface modification

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Sobierajska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 139 580 PLN

Project start date (Y-m-d): 2018-11-09

Project end date (Y-m-d): 2021-11-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Multifunctionality of nanosized calcium apatite dual-doped with Li+/Eu3+ ions related to cell culture studies and cytotoxicity evaluation in vitro
    Authors:
    Paulina Sobierajska, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Agata Piecuch, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and Rafal J. Wiglusz
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1388), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11091388 - link to the publication
  2. Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration After Mechanical Damage – In Vitro Study
    Authors:
    Benita Wiatrak, Paulina Sobierajska, Marta Szandruk-Bender, Paulina Jawien, Maciej Janeczek, Maciej Dobrzynski, Patrycja Pistor, Adam Szelag and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4454), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094454 - link to the publication
  3. The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms
    Authors:
    Wojciech Zakrzewski, Maciej Dobrzynski, Joanna Nowicka, Magdalena Pajaczkowska,Maria Szymonowicz, Sara Targonska, Paulina Sobierajska, Katarzyna Wiglusz, Wojciech Dobrzynski, Adam Lubojanski, Sebastian Fedorowicz, Zbigniew Rybak and Rafal J. Wiglusz
    Academic press:
    Nanomaterials (rok: 2020, tom: 10, strony: 1997), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano10101997 - link to the publication
  4. Investigation of topography effect on antibacterial properties and biocompatibility of nanohydroxyapatites activated with zinc and copper ions: In vitro study of colloids, hydrogel scaffolds and pellets
    Authors:
    Paulina Sobierajska, Nicole Nowak, Justyna Rewak-Soroczynska, Sara Targonska, Agnieszka Lewińska, Lukasz Grosman, Rafal J. Wiglusz
    Academic press:
    Materials Science and Engineering: C (rok: 2021, tom: b.d., strony: 112547), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.msec.2021.112547 - link to the publication
  5. Influence of Li+ ions on the physicochemical properties of nanocrystalline calcium–strontium hydroxyapatite doped with Eu3+ ions
    Authors:
    Paulina Sobierajska and Rafal J. Wiglusz
    Academic press:
    New Journal of Chemistry (rok: 2019, tom: 43, strony: 14908-14916), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9NJ03003D - link to the publication
  6. Nanohydroxyapatite-Mediated Imatinib Delivery for Specific Anticancer Applications
    Authors:
    Paulina Sobierajska, Anna Serwotka-Suszczak, Damian Szymanski, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4602), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204602 - link to the publication
  7. Nanoapatites Doped and Co-Doped with Noble Metal Ions as Modern Antibiofilm Materials for Biomedical Applications against Drug-Resistant Clinical Strains of Enterococcus faecalis VRE and Staphylococcus aureus MRSA
    Authors:
    Emil Paluch, Paulina Sobierajska, Piotr Okinczyc, Jarosław Widelski, Anna Duda-Madej, Barbara Krzyzanowska, Paweł Krzyzek, Rafał Ogorek, Jakub Szperlik, Jacek Chmielowiec, Grazyna Gosciniak and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1533), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031533 - link to the publication
  8. Synergistic effect of Toceranib and nanohydroxyapatite as a drug delivery platform – physicochemical properties and in vitro studies on mastocytoma cells
    Authors:
    Paulina Sobierajska, Anna Serwotka-Suszczak, Sara Targońska, Damian Szymanski, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1944), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23041944 - link to the publication

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