Projects funded by the NCN
Disclosing chromatin accessibility in brain tumor cells after treatment by cracking a 'nucleosomal code'
2017/27/B/NZ2/02827
Keywords:
chromatin histone variants histone modifications chromatin accessibility
Descriptors:
- NZ2_2: Genomics, transcriptomics, epigenomics
- NZ2_8: Computational biology
Panel:
NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution :
Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 14 - announced on 2017-09-15
Amount awarded: 1 568 500 PLN
Project start date (Y-m-d): 2018-09-03
Project end date (Y-m-d): 2022-09-02
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Serwer obliczeniowy (160 000 PLN)
- Bioanalizator (160 000 PLN)
- Komora PCR.
- Komputer osobisty/laptop (10 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cellsAuthors:Katarzyna B Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N L Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A Garcia, Jacek Majewski, Bozena Kaminska, Jakub MieczkowskiAcademic press:Cell Reports (rok: 2024, tom: 43(2), strony: 113707), Wydawca: Cell PressStatus:PublishedDOI:10.1016/j.celrep.2024.113707 - link to the publication
- Emerging Advances in Combinatorial Treatments of Epigenetically Altered Pediatric High-Grade H3K27M GliomasAuthors:Katarzyna B. Leszczynska, Chinchu Jayaprakash, Bozena Kaminska and Jakub Mieczkowski1Academic press:Frontiers in Genetics: Epigenomics and Epigenetics (rok: 2021, tom: 12, strony: 742561), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fgene.2021.742561 - link to the publication