Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The significance of exocytosis and IL10RA receptor in respect to the induction of suppression of immunological response in colorectal cancer by the intravesicular, extracellular transport

2017/27/N/NZ5/02020

Keywords:

Exocytosis IL10RA colorectal cancer

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Łukasz Zadka 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 200 200 PLN

Project start date (Y-m-d): 2018-07-26

Project end date (Y-m-d): 2021-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Interplay of stromal tumor-infiltrating lymphocytes, normal colonic mucosa, cancer-associated fibroblasts, clinicopathological data and the immunoregulatory molecules of patients diagnosed with colorectal cancer.
    Authors:
    Łukasz Zadka, Mariusz Chabowski, Damian Grybowski, Aleksandra Piotrowska, Piotr Dzięgiel
    Academic press:
    Cancer Immunology, Immunotherapy (rok: 2021, tom: 70, strony: 2681-2700), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    10.1007/s00262-021-02863-1 - link to the publication
  2. TYK2 protein expression as the first tissue-based biomarker for the diagnosis of colorectal cancer
    Authors:
    Łukasz Zadka, Adam Ustaszewski, Natalia Glatzel-Plucińska, Agnieszka Rusak, Izabela Łaczmańska, Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Aleksandra Piotrowska, Katarzyna Haczkiewicz-Leśniak, Agnieszka Gomułkiewicz, Magdalena Kostrzewska-Poczekaj, Piotr Dzięgiel
    Academic press:
    American Journal of Surgical Pathology (rok: 2021, ), Wydawca: LIPPINCOTT WILLIAMS & WILKINS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Comparative analysis of exosome markers and extracellular vesicles between colorectal cancer and cancer-associated normal colonic mucosa.
    Authors:
    Łukasz Zadka, Aleksandra Piotrowska, Agnieszka Opalińska, Katarzyna Haczkiewicz-Leśniak, Damian Grybowski, Ireneusz Ceremuga, Mariusz Chabowski, Piotr Dzięgiel
    Academic press:
    Polish Archives of Internal Medicine (rok: 2020, tom: 130, strony: 640-648), Wydawca: Medycyna Praktyczna (MP)
    Status:
    Published
    DOI:
    10.20452/pamw.15462 - link to the publication
  4. Molecular profiling of the intestinal mucosa and immune cells of the colon by multi-parametric histological techniques.
    Authors:
    Łukasz Zadka, Karolina Chrabaszcz, Igor Buzalewicz, Ewelina Wiercigroch, Natalia Glatzel-Plucińska, Łukasz Szleszkowski, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Krzysztof Kurnol, Piotr Dzięgiel, Tomasz Jurek, Kamilla Malek
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 11309), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-021-90761-y - link to the publication
  5. Label-free quantitative phase imaging reveals spatial heterogeneity of extracellular vesicles in selected colon disorders.
    Authors:
    Łukasz Zadka, Igor Buzalewicz, Agnieszka Ulatowska-Jarża, Agnieszka Rusak, Maria Kochel, Ireneusz Ceremuga, Piotr Dzięgiel
    Academic press:
    The American Journal of Pathology (rok: 2021, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.ajpath.2021.08.005 - link to the publication
  6. Extracellular vesicles present immunosuppressive and proangiogenic properties in human colorectal cancer
    Authors:
    Łukasz Zadka, Agnieszka Rusak, Ben Peacock, Alice Law, Aleksandra Piotrowska, Katarzyna Haczkiewicz-Leśniak, Dimitri Aubert, Piotr Dzięgiel.
    Academic press:
    Cancer Immunology Research (rok: 2021, ), Wydawca: AMER ASSOC CANCER RESEARCH
    Status:
    Submitted
    DOI:
    brak - link to the publication

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