The role of Mcpip1 RNase in disrupted endothalial homeostasis accompanying nonalcoholic fatty liver disease.
2017/27/B/NZ5/01440
Keywords
Descriptors
- NZ5_1: Etiologia chorób człowieka
- NZ5_3: Patogeneza chorób człowieka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
OPUS 14 – announced on 2017-09-15
- Amount awarded
- 1 212 400 PLN
- Project start date
- 2018-06-29
- Project end date
- 2022-08-28
- Project duration
- 50 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- aparat do elektroforezy.
- autoklaw. Cost: 6 836 PLN
- chłodziarka do analizatora biochemicznego.
- homogenizator elektryczny. Cost: 10 000 PLN
- komora laminarna do hodowli komórkowej typu II. Cost: 55 000 PLN
- kołyska 2D. Cost: 7 000 PLN
- kuchenka mikrofalowa. Cost: 399 PLN
- oprogramowanie do obróbki statystycznej. Cost: 4 388 PLN
- wirówka nablatowa. Cost: 5 000 PLN
Information in the final report
Publication in academic press/journals (4)
-
Selected transgenic murine models of human autoimmune liver diseases.
- Authors:
- Katarzyna Trzos, Natalia Pydyn, Jolanta Jura, Jerzy Kotlinowski
- Academic press:
- Pharmacological Reports (year: 2022, volume: online, pages: online), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s43440-021-00351-y – link to the publication
-
Hepatic Mcpip1 regulates adaptation to food restriction in mice.
- Authors:
- Olga Mucha, Bozena Skupien-Rabian, Alicja Slota, Katarzyna Trzos, Bartosz Podlewski, Jolanta Jura, Jerzy Kotlinowski
- Academic press:
- Acta Biochimica Polonica (year: 2023, volume: online ahead of print, pages: n/n), Publisher: Polish Biochemical Society
- Status:
- Published
- DOI:
- 10.18388/abp.2020_6819 – link to the publication
-
Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts.
- Authors:
- Natalia Pydyn, Dariusz Żurawek, Joanna Kozieł, Edyta Kus, Kamila Wojnar-Lason, Agnieszka Jasztal, Mingui Fu, Jolanta Jura, Jerzy Kotlinowski
- Academic press:
- The FEBS Journal (year: 2021, volume: 288, pages: 6563-6580), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1111/febs.16040 – link to the publication
-
Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis
- Authors:
- Jerzy Kotlinowski, Tomasz Hutsch, Izabela Czyzynska-Cichon, Marta Wadowska, Natalia Pydyn, Agnieszka Jasztal, Agnieszka Kij, Ewelina Dobosz, Maciej Lech, Katarzyna Miekus, Ewelina Pośpiech, Mingui Fu, Jolanta Jura, Joanna Koziel, Stefan Chlopicki
- Academic press:
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (year: 2021, volume: 1867, pages: 166086), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbadis.2021.166086. – link to the publication