Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Role of TBC1D5 phosphorylation in neurodevelopment and TSC-related cell pathology

2017/27/B/NZ3/01358

Keywords:

TBC1D5 mTOR retromer neurogenesis TSC

Descriptors:

  • NZ3_5:
  • NZ3_6:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Ryszard Jaworski 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 795 700 PLN

Project start date (Y-m-d): 2018-07-02

Project end date (Y-m-d): 2022-06-01

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Pathological mTOR mutations impact cortical development.
    Authors:
    Tarkowski B, Kuchcinska K, Blazejczyk M, Jaworski J.
    Academic press:
    Human Molecular Genetics (rok: 2019, tom: 28(13), strony: 2107-2119), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/hmg/ddz042 - link to the publication
  2. mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types
    Authors:
    Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska , Jacek Jaworski
    Academic press:
    Cell Mol Biol Lett . (rok: 2021, tom: 26, strony: 45675), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s11658-021-00262-z - link to the publication
  3. mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types
    Authors:
    Alicja Koscielny, Ewa Liszewska, Katarzyna Machnicka, Michalina Wezyk, Katarzyna Kotulska , Jacek Jaworski
    Academic press:
    Cell Mol Biol Lett . (rok: 2021, tom: 26, strony: 45675), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s11658-021-00262-z - link to the publication
  4. Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner
    Authors:
    Janusz-Kaminska A, Brzozowska A, Tempes A, Urbanska M, Blazejczyk M, Miłek J, Kuzniewska B, Zeng J, Wesławski J, Kisielewska K, Bassell GJ, Jaworski J.
    Academic press:
    Mol Biol Cell. (rok: 2024, tom: 35(3):ar43, strony: 45677), Wydawca: ACSB
    Status:
    Published
    DOI:
    10.1091/mbc.E23-02-0060 - link to the publication
  5. Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning
    Authors:
    Janusz-Kaminska, Jaworski J.
    Academic press:
    Autophagy Reports (rok: 2024, tom: 3:1, 2346064, strony: 45661), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/27694127.2024.2346064 - link to the publication

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