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Study on the mechanisms of antidiabetic properties of steviol glucosides (alone and combined with L-arginine and chromium(III) - in search for a supplementary formula for diabetics

2017/27/B/NZ9/00677

Keywords

Descriptors

  • NZ9_7: Naukowe podstawy żywienia i badania żywności
  • NZ4_11: Metabolizm

Panel

NZ9 – Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution

Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Zbigniew Krejpcio

Number of co-investigators in the project: 9

Call

OPUS 14 – announced on 2017-09-15

Amount awarded
1 107 700 PLN
Project start date
2018-06-29
Project end date
2023-08-28
Project duration
62 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (9)

  1. Determination of antidiabetic activity of steviol glycosides by evaluation of α-glucosidase inhibition in vitro.

    Authors:
    Jakub Michał Kurek, Anna Gościniak, Judyta Cielecka-Piontek, Zbigniew Krejpcio
    Academic press:
    Żywność jako wyzwanie dla współczesnej nauki i przemysłu.Monografia pod redakcją naukową Emilii Bernaś, Doroty Gałkowskiej, Kingi Topolskiej Polskie Towarzystwo Technologów Żywności Wydawnictwo Naukowe PTTŻ Kraków (year: 2023, volume: 1, pages: 194-204), Publisher: Monografia pod redakcją naukową Emilii Bernaś, Doroty Gałkowskiej, Kingi Topolskiej Polskie Towarzystwo Technologów Żywności Wydawnictwo Naukowe PTTŻ Kraków, ISBN 978-95-3897-5-7
    Status:
    Published

  2. The Potential of L-Arginine in Prevention and Treatment of Disturbed Carbohydrate and Lipid Metabolism—A Review

    Authors:
    Aleksandra Szlas , Jakub Michał Kurek and Zbigniew Krejpcio
    Academic press:
    Nutrients (year: 2022, volume: 14, 961, pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nu14050961 – link to the publication

  3. Steviol Glycosides Supplementation Affects Lipid Metabolism in High-Fat Fed STZ-Induced Diabetic Rats.

    Authors:
    Kurek, J.M.; Król, E.; Krejpcio, Z.
    Academic press:
    Nutrients (year: 2021, volume: 13(1), pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13010112 – link to the publication

  4. The Functional and Health-Promoting Properties of Stevia Rebaudiana Bertoni and Its Glycosides with Special Focus on the Antidiabetic Potential - a Review.

    Authors:
    Jakub Michał Kurek, Zbigniew Krejpcio
    Academic press:
    Journal of Functional Foods (year: 2019, volume: 61, pages: 103465), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jff.2019.103465 – link to the publication

  5. Steviol glycosides from Stevia rebaudiana Bertoni mitigate lipid metabolism abnormalities in diabetes by modulating selected gene expression – An in vivo study.

    Authors:
    Jakub Michał Kurek, Joanna Mikołajczyk-Stecyna , Zbigniew Krejpcio
    Academic press:
    Biomedicine & Pharmacotherapy (year: 2023, volume: 166, pages: 115424), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.115424 – link to the publication

  6. Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet.

    Authors:
    Jakub Michał Kurek , Ewelina Król, Halina Staniek and Zbigniew Krejpcio
    Academic press:
    Pharmaceuticals (year: 2022, volume: 15, pages: 46046), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15101200 – link to the publication

  7. Modulating effects of steviol and steviol glycosides on adipogenesis, lipogenesis, glucose uptake and insulin resistance in 3T3-L1 adipocyte model

    Authors:
    Jakub Michał Kurek, Joanna Zielińska-Wasielica, Katarzyna Kowalska, Zbigniew Krejpcio
    Academic press:
    Journal of Functional Foods (year: 2022, volume: 94, pages: 46033), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jff.2022.105141 – link to the publication

  8. Steviol glycosides, l-arginine, and chromium(III) affect trace element status in diabetic rats.

    Authors:
    Jakub Michał Kurek, Ewelina Król, Halina Staniek, Zbigniew Krejpcio
    Academic press:
    Acta Scientiarum Polonorum Technologia Alimentaria (year: 2024, volume: 23(3), pages: 345–356), Publisher: Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu
    Status:
    Published
    DOI:
    10.17306/J.AFS.001258 – link to the publication

  9. Steviol glycosides affect trace element status in diabetic rats.

    Authors:
    Jakub Michał Kurek, Ewelina Król, Halina Staniek, Zbigniew Krejpcio
    Status:
    Accepted for publication

Articles in post-conference publications (21)

  1. Najważniejsze osiągnięcia projektu naukowo-badawczego DiabetHelp (NCN 2017/27/B/NZ9/00677)

    Authors:
    Krejpcio Z., Kurek J.M., Olejnik A., Kowalska K., Zielińska-Wasielica J., Staniek H., Król E., Tubacka M., Skrzypski M., Wojciechowicz T., Mikołajczyk-Stecyna J.
    Conference:
    X Konferencja Naukowa Fizjologiczne uwarunkowania postępowania dietetycznego, Warszawa (year: 2024, pages: 53), Publisher: Wydawnictwo SGGW
    Date:
    conference 2024-11-14-15
    Status:
    Published

  2. Effects of supplementary steviol glycosides on tissular trace elements levels in type 2 diabetic rats.

    Authors:
    Jakub Michał Kurek and Zbigniew Krejpcio
    Conference:
    10th International Congress of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, November 30th -December 2nd, 2022. (year: 2022, pages: 118), Publisher: 10th International Congress of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia
    Date:
    conference 2022-11-30-2022-12-02
    Status:
    Published

  3. Steviol Glycosides and Lipid Profile Regulation — is it the Type or the Dose that Really Matters ?.

    Authors:
    Jakub Michał Kurek, Ewelina Król, Zbigniew Krejpcio
    Conference:
    The 15th Annual International Conference of the D&CVD Study Group (D&CVD2023), (year: 2023, pages: 166), Publisher: Diabetes, Stoffwechsel und Hertz
    Date:
    conference 2023-05-10-12
    Status:
    Published

  4. Co-Supplementary Steviol Glycosides, L-Arginine and Cr(III) Improve Blood Antioxidant Status Biomarkers in Mildly Diabetic Rats Fed High-Fat Diet

    Authors:
    Jakub Michał Kurek, Zbigniew Krejpcio
    Conference:
    GSFST2023, 2nd Global Summit on Food Science and Technology (year: 2023, pages: 108-109), Publisher: The Scientistt
    Date:
    conference 2023-03-23-25
    Status:
    Published

  5. Is supplementary chromium(III) beneficial for treating diabetes? A reference to own study.

    Authors:
    Zbigniew Krejpcio, Jakub Michał Kurek
    Conference:
    III Bio.Natural- Bioactive Natural Products Research Conference, Lisbon, Portugal and Online (year: 2023, pages: 52), Publisher: III Bio.Natural
    Date:
    conference 2023-07-13-14
    Status:
    Published

  6. Supplementary Steviol Glycosides Can Regulate Lipid Metabolism in Diabetes.

    Authors:
    Zbigniew Krejpcio, Jakub Michał Kurek, Ewelina Król, Joanna Mikołajczyk-Stecyna, Joanna Zielińska-Wasielica, Katarzyna Kowalska, Anna Olejnik
    Conference:
    The 15th Annual International Conference of the D&CVD Study Group (D&CVD2023) (year: 2023, pages: 165-166), Publisher: Diabetes, Stoffwechsel und Hertz, www.diabetologie-online.de
    Date:
    conference 2023-05-10-12
    Status:
    Published

  7. Steviol glycosides and glucose metabolism related protein levels in diabetic rats.

    Authors:
    Jakub Michał Kurek, Marek Skrzypski, Dawid Szczepankiewicz, Tatiana Wojciechowicz, Zbigniew Krejpcio
    Conference:
    III Bio.Natural- Bioactive Natural Products Research Conference, Lisbon, Portugal and online (year: 2023, pages: 52-53), Publisher: III BIO.NATURAL
    Date:
    conference 2023-07-13-14
    Status:
    Published

  8. Stevia rebaudiana Bertoni –właściwości funkcjonalne oraz prozdrowotne z wyszczególnieniem potencjału działania przeciwcukrzycowego.

    Authors:
    Jakub M. Kurek, Zbigniew Krejpcio
    Conference:
    XXIV Sesja Naukowa, Sekcji Młodej Kadry Naukowej PTTŻ oraz VII International Session of Young Scientific Staff. MIĘDZYNARODOWA KONFERENCJA NAUKOWA Żywność –wczoraj, dziś i na zdrowe jutro (year: 2019, pages: 86), Publisher: UWM Olsztyn
    Date:
    conference 2019-05-23-24
    Status:
    Published

  9. Stevia rebaudiana Bertoni and its glycosides as promising phytochemicals with anti-diabetic potential.

    Authors:
    Jakub Kurek, Zbigniew Krejpcio
    Conference:
    The 13th European Nutrition Conference - FENS 2019, Dublin, Ireland (year: 2019, pages: wersja elektroniczna), Publisher: FENS
    Date:
    conference 2019-10-15-18
    Status:
    Published
    DOI:
    link to the publication

  10. Ocena właściwości przeciwdrobnoustrojowych ekstraktów rośliny Stevia rebaudiana Bertoni

    Authors:
    Jakub Michał Kurek, Tomasz Szablewski, Kinga Stuper-Szablewska, Zbigniew Krejpcio
    Conference:
    XXV Jubileuszowa Sesja Naukowa Sekcji Młodej Kadry Naukowej PTTŻ, Wrocław (year: 2021, pages: 59), Publisher: WYDAWNICTWO UNIWERSYTETU PRZYRODNICZEGO WE WROCŁAWIU
    Date:
    conference 20-21 maja
    Status:
    Published

  11. Wpływ glikozydów stewiolowych na wybrane wskaźniki biochemiczne krwi u szczurów z wywołaną cukrzycą

    Authors:
    Jakub Michał Kurek, Ewelina Król, Małgorzata Tubacka, Zbigniew Krejpcio
    Conference:
    XXVIII Ogólnopolskie Sympozjum Bromatologiczne – Gdańsk (year: 2020, pages: 82), Publisher: Gdański Uniwersytet Medyczny, Gdańsk
    Date:
    conference 47389
    Status:
    Published

  12. Czy chrom jest niezbędnym mikroelementem, czy artefaktem ?

    Authors:
    Zbigniew Krejpcio
    Conference:
    XXVIII Ogólnopolskie Sympozjum Bromatologiczne – Gdańsk (year: 2020, pages: 20), Publisher: Gdański Uniwersytet Medyczny
    Date:
    conference 47389
    Status:
    Published

  13. Effects of steviol on cytotoxicity, adipogenesis, ROS concentration and gene expression in 3T3-L1 Cell Line.

    Authors:
    Jakub Kurek, Joanna Zielińska-Wasielica, Katarzyna Kowalska, Anna Olejnik, Zbigniew Krejpcio
    Conference:
    The 3th European Nutrition Conference - FENS 2019 Dublin, Ireland (year: 2019, pages: elektroniczne), Publisher: FENS
    Date:
    conference 2019-10-15-18
    Status:
    Published
    DOI:
    link to the publication

  14. Wpływ rodzaju i ilości glikozydów stewiolowych w diecie na ekspresję genów związanych z gospodarką węglowodanowo-lipidową u szczurów z wywołaną cukrzycą typu 2

    Authors:
    Jakub Michał Kurek, Joanna Mikołajczyk-Stecyna, Zbigniew Krejpcio
    Conference:
    XLV Sesja Naukowa Komitetu Nauk o Żywności i Żywieniu, Gdańsk (year: 2021, pages: 118), Publisher: Politechnika Gdańska
    Date:
    conference 1-2 lipca
    Status:
    Published

  15. Steviol glycosides from Stevia rebaudiana Bertoni normalise lipid metabolism by modulating selected gene expression in diabetic rats.

    Authors:
    Jakub Michał Kurek, Joanna Mikołajczyk-Stecyna, Zbigniew Krejpcio
    Conference:
    21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore), 31 October - 3 November 2022. Abstracts - IUFoST 2022, Singapore (year: 2022, pages: 342), Publisher: 21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore
    Date:
    conference 2022-10-31-2022-11-03
    Status:
    Published

  16. Stevia-derived compounds improve glucose uptake and alleviate insulin resistance in the 3T3-L1 adipocytes.

    Authors:
    Joanna Zielińska-Wasielica, Katarzyna Kowalska, Zbigniew Krejpcio, Anna Olejnik
    Conference:
    21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore), 31 October - 3 November 2022. (year: 2022, pages: 343), Publisher: Abstracts - IUFoST 2022, Singapore
    Date:
    conference 2022-10-31-2022-11-03
    Status:
    Published

  17. Steviol glycosides attenuate lipid metabolism abnormalities by affecting gene expression in type 2 diabetic rats.

    Authors:
    Jakub Michał Kurek, Joanna Mikołajczyk-Stecyna, Zbigniew Krejpcio
    Conference:
    10th International Congress of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia, November 30th-December 2nd, 2022. (year: 2022, pages: 117), Publisher: 10th International Congress of Food Technologists, Biotechnologists and Nutritionists, Zagreb, Croatia
    Date:
    conference 2022-11-30-2022-12-02
    Status:
    Published

  18. Supplementary steviol glycosides in combination with L-arginine and chromium(III) improve selected nutritional indices in mildly diabetic rats.

    Authors:
    Jakub Michał Kurek, Ewelina Król, Zbigniew Krejpcio
    Conference:
    21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore), 31 October - 3 November 2022. Abstracts - IUFoST 2022, Singapore (year: 2022, pages: 353), Publisher: 21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore)
    Date:
    conference 2022-10-31-2022-11-03
    Status:
    Published

  19. Effects of supplementary steviol glycosides in combination with L-arginine and chromium(III) on tissular trace mineral contents in mildly diabetic rats.

    Authors:
    Jakub Michał Kurek, Ewelina Król, Zbigniew Krejpcio
    Conference:
    21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore), 31 October - 3 November 2022. Abstracts - IUFoST 2022, Singapore (year: 2022, pages: 352), Publisher: 21st IUFoST World Congress of Food Science & Technology (IUFoST'2022, Singapore)
    Date:
    conference 2022-10-31-2022-11-03
    Status:
    Published

  20. Wpływ rodzaju glikozydów stewiolowych oraz dodatku L-argininy i chromu (III) w diecie na wybrane markery gospodarki węglowodanowo-lipidowej u szczurów z wywołaną cukrzycą typu 2

    Authors:
    Kurek Jakub Michał, Król Ewelina, Staniek Halina, Tubacka Małgorzata, Krejpcio Zbigniew
    Conference:
    I Ogólnopolska Konferencja Naukowa Żywność i żywienie w pigułce, Gdańsk, 2022 (year: 2022, pages: 103), Publisher: Gdańsk : Komitet Organizacyjny I Ogólnopolskiej Konferencji Naukowej Żywność i żywienie w pigułce, 2022
    Date:
    conference 44660
    Status:
    Published

  21. Steviol Glycosides Attenuate Histological Alterations in Liver of Diabetic Rats fed High-Fat Diet

    Authors:
    Jakub Michał Kurek, Joanna Mikołajczyk Stecyna, Zbigniew Krejpcio
    Conference:
    GSFST2023, 2nd Global Summit on Food Science and Technology (year: 2023, pages: 106-107), Publisher: The Scientistt
    Date:
    conference 2023-03-23-25
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski