Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Expression of microRNA and its effect on the level of proteins with neuroprotective properties in the pathogenesis of the multiple sclerosis

2017/27/B/NZ7/02527

Keywords:

microRNA neuroprotection multiple sclerosis

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, Oddział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ireneusz Majsterek 

Number of co-investigators in the project: 6

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 214 388 PLN

Project start date (Y-m-d): 2018-08-14

Project end date (Y-m-d): 2023-08-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wirówka z dodatkowymi rotorami (80 000 PLN)
  2. zamrażarka niskotemperaturowa -70 st.C.
  3. Komora laminarna (60 000 PLN)
  4. Dewar na ciekły azot (10 000 PLN)
  5. Płuczka Multiwash Plus (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. miRNA-Dependent CD4+ T Cell Differentiation in the Pathogenesis of Multiple Sclerosis
    Authors:
    Justyna Basak, Ireneusz Majsterek.
    Academic press:
    Multiple Sclerosis International (rok: 2021, tom: 2021, strony: 45302), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/8825588 - link to the publication
  2. Neuroprotective Effects of BDNF, NT4/5, SIRT1, HSP70, and 2 HSP27 Genes in Multiple Sclerosis Patients
    Authors:
    Sokolowski I, Kucharska-Lusina A, Miller E, Majsterek I
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 23, strony: 45307), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    10.3390/xxxxx - link to the publication
  3. Association between the Cytosine Hydroxymethylation and the Expression of microRNA in Multiple Sclerosis in Polish Population
    Authors:
    Basak J, Piotrzkowska D, Kucharska-Lusina A, Majsterek I
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241813923 - link to the publication
  4. Association of miRNA and mRNA levels of the clinical onset of 2 multiple sclerosis patients
    Authors:
    Piotrzkowska D, Miller E, Kucharska E, Niwald M, Majsterek I
    Academic press:
    MDPI-biology (rok: 2021, tom: 10, 554, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biology10060554 - link to the publication
  5. The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
    Authors:
    Rozpędek-Kamińska W, Siwecka N, Wawrzynkiewicz A, Wojtczak R, Pytel D, Diehl JA, Majsterek I
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, 2108, strony: 14611), Wydawca: 1996-2020 MDPI (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms21062108 - link to the publication
  6. Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis
    Authors:
    Basak J, Piotrzkowska D, Majsterek I, Kucharska E
    Academic press:
    Biomedicines (rok: 2022, tom: 10, 3124, strony: 45334), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines10123124 - link to the publication
  1. Znaczenie ekspresji miR-548ab, miR-26a, miR-150-3p, miR-21-5p, miR132-3p, miR-132-5p w patogenezie stwardnienia rozsianego
    Authors:
    Basak J, Piotrzkowska D, Majsterek I
    Conference:
    VII Ogólnopolska Konferencja Doktorantów Nauk o Życiu BioOpen (rok: 2022, ), Wydawca: Uniwersytet Medyczny w Łodzi
    Data:
    konferencja 07-08.04
    Status:
    Published
  2. THE SIGNIFICANCE OF THE POLYMORPHISMS OF THE microRNA PROCESSING GENES IN THE PATHOGENIS OF MULTIPLE SCLEROSIS
    Authors:
    Justyna Basak, Danuta Piotrzkowska, Ireneusz Majsterek
    Conference:
    DocUMED, II Interdyscyplinarna Konferencja Doktorantów Uczelni Medycznych (rok: 2021, ), Wydawca: DOC-UMED
    Data:
    konferencja 22-24.10
    Status:
    Published
  3. Wpływ miRNA na poziom ekspresji neurotrofin białek szoku cieplnego i sirtuiny SIRT1 w przebiegu stwardnienia rozsianego.
    Authors:
    Basak J, Piotrzkowska D, Majsterek I.
    Conference:
    I Interdyscyplinarna Konferencja Doktorantów Uniwersytetu Medycznego w Łodzi (rok: 2020, ), Wydawca: Uniwersytet Medyczny w Łodzi
    Data:
    konferencja 7,11
    Status:
    Published

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