Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Flavin based tools for monitoring and controling redox environment in cell

2017/27/B/ST4/02494

Keywords:

spectroscopy photochemistry singlet oxygen fluorescence probes flavins

Descriptors:

  • ST4_17: Chemical reactions: mechanisms, thermodynamics, kinetics

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Sikorski 

Number of co-investigators in the project: 9

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 466 440 PLN

Project start date (Y-m-d): 2018-06-12

Project end date (Y-m-d): 2023-06-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. inkubator CO2 do hodowli komórek: termowytrząsarka (50 000 PLN)
  2. 3 komputery typu laptop.
  3. Laser z układem laserowej fotolizy błyskowej (430 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Book publications / chapters in book publications (1)
  1. Azodicarboxylate-free esterification with triphenylphosphine mediated by flavin and visible light: Method development and stereoselectivity control
    Authors:
    M. Marz, M. Kohout, T. Nevesely, J. Chudoba, D. Prukata, S. Nizinski, M. Sikorski, G. Burdzinski, R. Cibulka,
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2018, tom: 16, strony: 6809-6817), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8ob01822g - link to the publication
  2. Riboflavin degradation products; combined photochemical and Mass Spectrometry approach
    Authors:
    Małgorzata Insińska-Rak, Dorota Prukała, Anna Golczak, Emilia Fornal, Marek Sikorski
    Academic press:
    Journal of Photochemistry and Photobiology A: Chemistry (rok: 2020, tom: 403, strony: 112837- 1128), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotochem.2020.112837 - link to the publication
  3. Tetraacetyl riboflavin derivative mediates caspase 3/7 activation via MAPK in A431 cells upon blue light influence
    Authors:
    Izabela Buniowska, Norbert Wronski, Małgorzata Insinska-Rak, Marek Sikorski, Agnieszka Wolnicka-Glubisz
    Academic press:
    Photochemistry and Photobiology (rok: 2023, ), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/php.13806 - link to the publication
  4. Riboflavin and its derivates as potential photosensitizers in photodynamic treatment of skin cancers
    Authors:
    Małgorzata Insinska-Rak, Marek Sikorski, Agnieszka Wolnicka-Glubisz
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 2304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12182304 - link to the publication
  5. 5-Deazaalloxazine as photosensitizer of singlet oxygen and potential redox-sensitive agent
    Authors:
    Małgorzata Insińska-Rak, Anna Golczak, Mateusz Gierszewski, Zubair Anwar, Volodymyr Cherkas, Dorota Kwiatek, Ewa Sikorska, Igor Khmelinskii, Gotard Burdziński, Radek Cibulka, Lucyna Mrówczyńska, Jacek Lukasz Kolanowski, Marek Sikorski
    Academic press:
    Photochemical and Photobiological Sciences (rok: 2023, tom: 22, strony: 1655–1671), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s43630-023-00401-9 - link to the publication
  6. Photophysical properties of alloxazine derivatives with extended aromaticity – potential redox-sensitive fluorescent probe.
    Authors:
    Anna Golczak, Małgorzata Insińska-Rak, Amirali Davoudpour, Daban Hama Saeed, Petra Menova, Viktor Mojr, Radek Cibulka, Igor Khmelinskii, Lucyna Mrówczyńska, , Marek Sikorski
    Academic press:
    Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy (rok: 2022, tom: 272, strony: 120985), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2022.120985 - link to the publication
  7. Robust photocatalytic method using ethylene‐bridged flavinium salts for the aerobic oxidation of unactivated benzylic substrates
    Authors:
    Pokluda, A., Anwar, Z., Boguschová, V., Anusiewicz, I., Skurski, P., Sikorski, M., & Cibulka, R.
    Academic press:
    Advanced Synthesis & Catalysis (rok: 2021, tom: 363, strony: 45301), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/adsc.202100024 - link to the publication
  8. Tetramethylalloxazines as efficient singlet oxygen photosensitizers and potential redox-sensitive agents
    Authors:
    Anna Golczak, Dorota Prukała, Ewa Sikorska, Mateusz Gierszewski, Volodymyr Cherkas, Dorota Kwiatek, Adam Kubiak, Naisargi Varma, Tomasz Pędziński, Shaun Murphree, Radek Cibulka, Lucyna Mrówczyńska, Jacek Lukasz Kolanowski, Marek Sikorski
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 13426), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-40536-4 - link to the publication
  9. Combining flavin photocatalysis and organocatalysis: Metal-free aerobic oxidation of unactivated benzylic substrates
    Authors:
    J. Zelenka, E. Svobodová, J. Tarábek, I. Hoskovcová, V. Boguschová, S. Bailly, M. Sikorski, J. Roithová, R. Cibulka
    Academic press:
    Org. Lett. (rok: 2019, tom: 21, strony: 114-119), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.orglett.8b03547 - link to the publication
  10. Tuning the Photophysical Properties of Flavins by Attaching an Aryl Moiety via Direct C-C Bond Coupling
    Authors:
    Čubiňák, M., Varma, N., Oeser, P., Adam Pokluda, Tetiana Pavlovska, Radek Cibulka*, Sikorski, M., Tobrman, T.
    Academic press:
    Journal of Organic Chemistry (rok: 2023, tom: 88(1), strony: 218-229), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.joc.2c02168 - link to the publication
  1. Fluorescence spectroscopy and imaging instruments for food quality evaluation,
    Authors:
    E. Sikorska, I. Khmelinskii, M. Sikorski
    Book:
    Evaluation technologies for food quality (rok: 2019, tom: 1, strony: 491-533), Wydawca: Woodhead Publishing An imprint of Elsevier
    Status:
    Published

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