Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mechanisms of binding and transport in plasma of amyloid beta oligomers by human serum albumin (HSA) in presence of selected ligands

2017/27/B/ST4/00485

Keywords:

human serum albumin amyloid beta cystatin C ligand amyloid

Descriptors:

  • ST4_13:
  • ST4_3:
  • ST5_16:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Leszek Kozak 

Number of co-investigators in the project: 10

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 256 400 PLN

Project start date (Y-m-d): 2018-06-29

Project end date (Y-m-d): 2023-06-28

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (21)
  1. Characterization of uranyl (UO2 2+) ion binding to amyloid beta (Aβ) peptides: effects on Aβ structure and aggregation
    Authors:
    Elina Berntsson, Faraz Vosough, Andra Noormägi, Kärt Padari, Fanny Asplund, Maciej Gielnik, Suman Paul, Jüri Jarvet, Vello Tõugu, Per M. Roos, Maciej Kozak, Astrid Gräslund, Andreas Barth, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmlände
    Academic press:
    ACS Chemical Neuroscience (rok: 2023, tom: 14, strony: 2618–2633), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.3c00130 - link to the publication
  2. Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates
    Authors:
    Magdalena Chrabąszczewska, Maria Winiewska-Szajewska, Natalia Ostrowska, Elżbieta Bojarska, Janusz Stępiński, Łukasz Mancewicz, Maciej Łukaszewicz, Joanna Trylska, Michał Taube, Maciej Kozak, Edward Darżynkiewicz, Renata Grzela
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(20), strony: 45679), Wydawca: MDPI (Basel)
    Status:
    Published
    DOI:
    10.3390/ijms222010929 - link to the publication
  3. Magnetic moments of short-lived nuclei with part-per-million accuracy. Paving the way for applications of beta-detected NMR in chemistry and biology
    Authors:
    R. D. Harding, S. Pallada, J. Croese, A. Antusek, M. Baranowski, M. L. Bissell, L. Cerato, K. M. Dziubinska-Kuhn, W. Gins, F. P. Gustafsson, A. Javaji, R. B. Jolivet, A. Kanellakopoulos, B. Karg, M. Kempka, V. Kocman, M. Kozak, K. Kulesz, M. Madurga Flores, G. Neyens, R. Pietrzyk, J. Plavec, M. Pomorski, A. Skrzypczak, P. Wagenknecht, F. Wienholtz, J. Wolak, Z. Xu, D. Zakoucky and M. Kowalska
    Academic press:
    Physical Review X (rok: 2020, tom: 10, strony: 41061), Wydawca: American Physical Society
    Status:
    Published
    DOI:
    10.041061 - link to the publication
  4. Oligomerization of Human Cystatin C—An Amyloidogenic Protein: An Analysis of Small Oligomeric Subspecies
    Authors:
    Daria Wojciechowska, Michał Taube, Karolina Rucińska, Joanna Maksim, Maciej Kozak
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(21), strony: 13441), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113441 - link to the publication
  5. A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
    Authors:
    Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling & Matthew R. Groves
    Academic press:
    Communications Biology (rok: 2021, tom: 4, strony: Article number: 949), Wydawca: Springer-Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42003-021-02442-1 - link to the publication
  6. Identification of a Steric Zipper Motif in the Amyloidogenic Core of Human Cystatin C and Its Use for the Design of Self-Assembling Peptides
    Authors:
    Emilia Iłowska, Jakub Barciszewski, Mariusz Jaskólski, Augustyn Moliński, Maciej Kozak, Aneta Szymańska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(10), strony: 5800), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105800 - link to the publication
  7. Human cystatin C induces the disaggregation process of selected amyloid beta peptides – a structural and kinetic view
    Authors:
    Adriana Żyła, Anne Martel, Przemysław Jurczak, Augustyn Moliński, Aneta Szymańska & Maciej Kozak
    Academic press:
    Scientific Reports (rok: 2023, tom: 13,, strony: Article number: 20833), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-47514-w - link to the publication
  8. A bacteriophage mimic of the bacterial nucleoidassociated protein Fis
    Authors:
    Soumyananda Chakraborti, Dhanasekaran Balakrishnan, Alexander J. Trotter, William H. Gittens, Ally W.H. Yang, Arttu Jolma, Joy R. Paterson, Sylwia Świątek, Jacek Plewka, Fiona A. Curtis, Laura Y. Bowers, Lars-Olof Pålsson, Timothy R. Hughes, Michał Taube, Maciej Kozak, Jonathan G. Heddle, and Gary J. Sharples
    Academic press:
    Biochemical Journal (rok: 2020, tom: 477, strony: 1345–1362), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20200146 - link to the publication
  1. Structural studies and characteristics of interaction between amyloid-beta peptides and associated protein human cystatin c
    Authors:
    Adriana Żyła, Anne Martel, Michał Taube, Przemysław Jurczak, Igor Zhukov, Aneta Szymańska, Maciej Kozak
    Conference:
    NanoTech Poland 2021 (rok: 2021, ), Wydawca: NanoBioMedical Centre AMU
    Data:
    konferencja 2021-05-09 - 2021-05-11
    Status:
    Published
  2. Interactions between amyloid-beta peptides,human serum albumin and human cystatin C studied by the use of X-ray and light scattering, NMR spectroscopy and bioinformatics
    Authors:
    Adriana Żyła, Aneta Szymańska, Joanna Wolak, Michał Taube, Daria Grobys, Ewa Banachowicz, Igor Zhokov, Maciej Kozak
    Conference:
    The Joint Meeting of the Polish Synchrotron Radiation Society and SOLARIS Users (rok: 2020, ), Wydawca: PTPS
    Data:
    konferencja 2020-09-09 - 2020-09-11
    Status:
    Published
  3. Structural investigation of the amyloid aggregates in the presence of human serum albumin and human cystatin C
    Authors:
    Adriana Żyła, Augustyn Moliński, Michał Taube, Agnieszka Belczyk Ciesielska, Maciej Kozak, Wojciech Bal
    Conference:
    Konferencja międzynarodowa: Fourth Polish-Korean Conference on "Protein Folding: Theoretical and Experimental Approaches" (rok: 2018, ), Wydawca: Wydział Chemii UG, Fundacja PERSPEKTYWA
    Data:
    konferencja 43352
    Status:
    Published
  4. Molecular basis of selected neurodegenerative disorders – SAXS, SANS and MD studies
    Authors:
    Maciej Kozak, Adriana Żyła, Joanna Wolak, Aneta Szymańska, Maciej Gielnik, Michał Taube, Igor Zhukov, Kosma Szutkowski, Michał Nowakowski, Wojciech M. Kwiatek, A.I. Kuklin
    Conference:
    Konferencja międzynarodowa: 5th Polish-Korean Conference on "Protein Folding: Theoretical and Experimental Approaches" (rok: 2019, ), Wydawca: KIAS
    Data:
    konferencja 43724
    Status:
    Published
  5. The Study of Selected Complexes of Human Serum Albumin with Amyloid Beta Peptides and Human Cystatin C
    Authors:
    Adriana Żyła, Michał Taube, Augustyn Molinski, Igor Zhukov, Alexander Kuklin, Aneta Szymanska, Maciej Kozak
    Conference:
    64th Annual Meeting of Biophysical Society (rok: 2020, ), Wydawca: Cell Press
    Data:
    konferencja 2020-02-15 - 2020-02-19
    Status:
    Published
    DOI:
    link to the publication
  6. From disordered chain to fibrils SAXS and spectroscopic studies of protein fibrillation process
    Authors:
    Maciej Kozak, Maciej Gielnik, Michał Taube, Zuzanna Pietralik, Aneta Szymańska, Igor Zhukov, Michał Nowakowski, Wojciech Kwiatek
    Conference:
    Konferencja międzynarodowa: Fourth Polish-Korean Conference on "Protein Folding: Theoretical and Experimental Approaches" (rok: 2018, ), Wydawca: Wydział Chemii UG, Fundacja PERSPEKTYWA
    Data:
    konferencja 43352
    Status:
    Published
  7. Structural investigation interaction between amyloid-beta peptides and associated proteins the human serum albumin and human cystatin C
    Authors:
    Adriana Żyła, Przemysław Jurczak, Aneta Szymańska, Joanna Wolak, Michał Taube, Igor Zhukov, Alexander I. Kuklin, Maciej Kozak
    Conference:
    Condensed Matter Reserach at the IBR-2 - International Conference (rok: 2020, ), Wydawca: JINR Dubna (Russia)
    Data:
    konferencja 2020-10-12 - 2020-10-16
    Status:
    Published
  8. Influence of human serum albumin, human cystatin C and zinc ions on the amyloid  fibrilization process
    Authors:
    Joanna Wolak, Daria Wojciechowska, Augustyn Moliński, Maciej Kozak
    Conference:
    NanoTech Poland 2021 (rok: 2021, ), Wydawca: NanoBioMedical Centre AMU
    Data:
    konferencja 2021-05-09 - 2021-05-11
    Status:
    Published
  9. Flexibility of protein molecules in solution, crystals and in frozen state – some examples
    Authors:
    Maciej Kozak, Michał Taube, Daria Wojciechowska, Adriana Żyła, Maciej Gielnik, Michał Nowakowski, Igor Zhukov, Wojciech M. Kwiatek
    Conference:
    6th Polish-Korean Conference on Protein Folding: Theoretical and Experimental Approaches (rok: 2021, ), Wydawca: Wydział Chemii UG
    Data:
    konferencja 2021-09-17 - 2021-09-21
    Status:
    Published
  10. Small angle X-ray scattering studies concerning the oligomerization of human cystatin C.
    Authors:
    Daria Wojciechowska, Michał Taube, Augustyn Moliński, Maciej Kozak
    Conference:
    International School and Symposium on Synchrotron Radiation in Natural Science (rok: 2022, ), Wydawca: Polish Synchrotron Radiation Society
    Data:
    konferencja 22-25.08.2022
    Status:
    Published
  11. The domain swapping of human cystatin C induced by synchrotron radiation
    Authors:
    Michał Taube, Zuzanna Pietralik, Daria Wojciechowska, Aneta Szymańska, Kosma Szutkowski, Daniel Clemens, Anders Grubb, Maciej Kozak
    Conference:
    CYSTATINS 2022 (rok: 2022, ), Wydawca: Wydział Chemii UG
    Data:
    konferencja 16-18.06.2022
    Status:
    Published
  12. The Evidence of Cu2+ and Zn2+ Modulation of Key HSA, HCC, and Aβ Proteins Activity in Neurodegenerative Processes
    Authors:
    Wojciech M. Kwiatek, Michał Nowakowski, Joanna Wolak, Karolina Rucinska, Joanna Maksim, Michał Taube, Daria Wojciechowska, Ewa Banachowicz, Maciej Kozak
    Conference:
    Denver X-ray Conference - 72nd Annual Conference on Applications of X-ray Analysis (rok: 2023, ), Wydawca: DXC
    Data:
    konferencja 2023-08-07 - 2023-08-11
    Status:
    Published
  13. Human cystatin C - new challenges, new topics
    Authors:
    Maciej Kozak, Adriana Żyła, Augustyn Moliński, Joanna Wolak, Daria Wojciechowska, Michał Taube, Anne Martel, Przemysław Jurczak, Aneta Szymańska, Michał Nowakowski
    Conference:
    CYSTATINS 2022, (rok: 2022, ), Wydawca: Wydział Chemii UG
    Data:
    konferencja 16-18.06.2022
    Status:
    Published
  14. Structural studies of human serum albumin using cryo-EM up to 0.38 nm resolution
    Authors:
    Maciej Kozak, Michał Taube, Michał Rawski, Daria Wojciechowska Joanna Sławek
    Conference:
    67th Annual Biophysical Society Meeting (rok: 2023, ), Wydawca: Cell Press
    Data:
    konferencja 18-22 lutego
    Status:
    Published
    DOI:
    link to the publication
  15. Characteristics of the relationship between amyloid-beta oligomers with Human Cystatin C
    Authors:
    Adriana Żyła, Anne Martel, Michał Taube, Przemysław Jurczak, Igor Zhukov, Aneta Szymańska, Maciej Kozak
    Conference:
    Synchrotron Radiation in Investigations of Condensed Matter (rok: 2021, ), Wydawca: ZIBJ Dubna
    Data:
    konferencja 2021-10-12 - 2021-10-13
    Status:
    Published
  16. Conformational dynamics of human cystatin C - an extended view on the structure based on XAS, AFM, SAXS and SANS
    Authors:
    Maciej Kozak, Joanna Wolak, Daria Wojciechowska, Adriana Żyła, Augustyn Moliński, Michał Taube, Ewa Banachowicz, Anne Martel, Przemyslaw Jurczak, Aneta Szymanska, Michał Nowakowski
    Conference:
    Joint Meeting of the 20th KIAS Conference on Protein Structureand Function and The 7th Korean-Polish Conference on "ProteinFolding: Theoretical and Experimental Approaches" (rok: 2022, ), Wydawca: KIAS
    Data:
    konferencja 14-17.09.2022
    Status:
    Published
  17. Analysis molecular dynamic processes in human cystatin C in different environments based on 15N relaxation data collected by several NMR techniques
    Authors:
    Igor Zhukov, Przemysław Jurczak, Kosma Szutkowski, Aneta Szymańska, Maciej Kozak
    Conference:
    CYSTATINS 2022 (rok: 2022, ), Wydawca: Wydział Chemii UG
    Data:
    konferencja 16-18.06.2022
    Status:
    Published
  18. Structural and biophysical studies of the plant m6A methyltransferase complex
    Authors:
    M. Taube, I. Zhukov, K. Szutkowski, A. Jarmołowski, Z. Szweykowska-Kulinska, M. Kozak
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published
  19. Structural insights into an amyloid beta aggregation in presence of human serum albumin and human cystatin C
    Authors:
    Adriana Żyła, Michał Taube, Maciej Kozak, Kosma Szutkowski, Wojciech Bal
    Conference:
    NANOTECH Poland (rok: 2019, ), Wydawca: NanoBioMed Centre
    Data:
    konferencja 43621
    Status:
    Published
  20. Search for the perfect buffer - HCC oligomerization studies
    Authors:
    Daria Wojciechowska, Michał Taube, Maciej Kozak
    Conference:
    CYSTATINS 2022 (rok: 2022, ), Wydawca: Wydział Chemii UG
    Data:
    konferencja 16-18.06.2022
    Status:
    Published
  21. Structural analysis and molecular dynamic processes in the human cystatin C at presence of human serum albumin (HSA) by means NMR spectroscopy
    Authors:
    I. Zhukov, A. Szymanska, P. Jurczak, W. Bal, M. Kozak
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published

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