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Mechanisms of binding and transport in plasma of amyloid beta oligomers by human serum albumin (HSA) in presence of selected ligands

2017/27/B/ST4/00485

Keywords

Descriptors

  • ST4_13: Chemia fizyczna układów biologicznych
  • ST4_3: Metody spektroskopowe i spektrometryczne
  • ST5_16: Chemia biologiczna

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Maciej Leszek Kozak

Number of co-investigators in the project: 10

Call

OPUS 14 – announced on 2017-09-15

Amount awarded
1 256 400 PLN
Project start date
2018-06-29
Project end date
2023-06-28
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (8)

  1. Characterization of uranyl (UO2 2+) ion binding to amyloid beta (Aβ) peptides: effects on Aβ structure and aggregation

    Authors:
    Elina Berntsson, Faraz Vosough, Andra Noormägi, Kärt Padari, Fanny Asplund, Maciej Gielnik, Suman Paul, Jüri Jarvet, Vello Tõugu, Per M. Roos, Maciej Kozak, Astrid Gräslund, Andreas Barth, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmlände
    Academic press:
    ACS Chemical Neuroscience (year: 2023, volume: 14, pages: 2618–2633), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.3c00130 – link to the publication

  2. Human cystatin C induces the disaggregation process of selected amyloid beta peptides – a structural and kinetic view

    Authors:
    Adriana Żyła, Anne Martel, Przemysław Jurczak, Augustyn Moliński, Aneta Szymańska & Maciej Kozak
    Academic press:
    Scientific Reports (year: 2023, volume: 13,, pages: Article number: 20833), Publisher: Springer-Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-47514-w – link to the publication

  3. A bacteriophage mimic of the bacterial nucleoidassociated protein Fis

    Authors:
    Soumyananda Chakraborti, Dhanasekaran Balakrishnan, Alexander J. Trotter, William H. Gittens, Ally W.H. Yang, Arttu Jolma, Joy R. Paterson, Sylwia Świątek, Jacek Plewka, Fiona A. Curtis, Laura Y. Bowers, Lars-Olof Pålsson, Timothy R. Hughes, Michał Taube, Maciej Kozak, Jonathan G. Heddle, and Gary J. Sharples
    Academic press:
    Biochemical Journal (year: 2020, volume: 477, pages: 1345–1362), Publisher: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20200146 – link to the publication

  4. A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

    Authors:
    Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling & Matthew R. Groves
    Academic press:
    Communications Biology (year: 2021, volume: 4, pages: Article number: 949), Publisher: Springer-Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42003-021-02442-1 – link to the publication

  5. Identification of a Steric Zipper Motif in the Amyloidogenic Core of Human Cystatin C and Its Use for the Design of Self-Assembling Peptides

    Authors:
    Emilia Iłowska, Jakub Barciszewski, Mariusz Jaskólski, Augustyn Moliński, Maciej Kozak, Aneta Szymańska
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23(10), pages: 5800), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105800 – link to the publication

  6. Oligomerization of Human Cystatin C—An Amyloidogenic Protein: An Analysis of Small Oligomeric Subspecies

    Authors:
    Daria Wojciechowska, Michał Taube, Karolina Rucińska, Joanna Maksim, Maciej Kozak
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23(21), pages: 13441), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113441 – link to the publication

  7. Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates

    Authors:
    Magdalena Chrabąszczewska, Maria Winiewska-Szajewska, Natalia Ostrowska, Elżbieta Bojarska, Janusz Stępiński, Łukasz Mancewicz, Maciej Łukaszewicz, Joanna Trylska, Michał Taube, Maciej Kozak, Edward Darżynkiewicz, Renata Grzela
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22(20), pages: 46044), Publisher: MDPI (Basel)
    Status:
    Published
    DOI:
    10.3390/ijms222010929 – link to the publication

  8. Magnetic moments of short-lived nuclei with part-per-million accuracy. Paving the way for applications of beta-detected NMR in chemistry and biology

    Authors:
    R. D. Harding, S. Pallada, J. Croese, A. Antusek, M. Baranowski, M. L. Bissell, L. Cerato, K. M. Dziubinska-Kuhn, W. Gins, F. P. Gustafsson, A. Javaji, R. B. Jolivet, A. Kanellakopoulos, B. Karg, M. Kempka, V. Kocman, M. Kozak, K. Kulesz, M. Madurga Flores, G. Neyens, R. Pietrzyk, J. Plavec, M. Pomorski, A. Skrzypczak, P. Wagenknecht, F. Wienholtz, J. Wolak, Z. Xu, D. Zakoucky and M. Kowalska
    Academic press:
    Physical Review X (year: 2020, volume: 10, pages: 41061), Publisher: American Physical Society
    Status:
    Published
    DOI:
    10.1103/PhysRevX.10.041061 – link to the publication

Articles in post-conference publications (21)

  1. Human cystatin C - new challenges, new topics

    Authors:
    Maciej Kozak, Adriana Żyła, Augustyn Moliński, Joanna Wolak, Daria Wojciechowska, Michał Taube, Anne Martel, Przemysław Jurczak, Aneta Szymańska, Michał Nowakowski
    Conference:
    CYSTATINS 2022, (year: 2022, pages: 10), Publisher: Wydział Chemii UG
    Date:
    conference 16-18.06.2022
    Status:
    Published

  2. Analysis molecular dynamic processes in human cystatin C in different environments based on 15N relaxation data collected by several NMR techniques

    Authors:
    Igor Zhukov, Przemysław Jurczak, Kosma Szutkowski, Aneta Szymańska, Maciej Kozak
    Conference:
    CYSTATINS 2022 (year: 2022, pages: 16), Publisher: Wydział Chemii UG
    Date:
    conference 16-18.06.2022
    Status:
    Published

  3. The domain swapping of human cystatin C induced by synchrotron radiation

    Authors:
    Michał Taube, Zuzanna Pietralik, Daria Wojciechowska, Aneta Szymańska, Kosma Szutkowski, Daniel Clemens, Anders Grubb, Maciej Kozak
    Conference:
    CYSTATINS 2022 (year: 2022, pages: 17), Publisher: Wydział Chemii UG
    Date:
    conference 16-18.06.2022
    Status:
    Published

  4. Structural studies of human serum albumin using cryo-EM up to 0.38 nm resolution

    Authors:
    Maciej Kozak, Michał Taube, Michał Rawski, Daria Wojciechowska Joanna Sławek
    Conference:
    67th Annual Biophysical Society Meeting (year: 2023, pages: Biophysical Journal 122(3), SUPPLEMENT 1, 465A,), Publisher: Cell Press
    Date:
    conference 18-22 lutego
    Status:
    Published
    DOI:
    link to the publication

  5. Flexibility of protein molecules in solution, crystals and in frozen state – some examples

    Authors:
    Maciej Kozak, Michał Taube, Daria Wojciechowska, Adriana Żyła, Maciej Gielnik, Michał Nowakowski, Igor Zhukov, Wojciech M. Kwiatek
    Conference:
    6th Polish-Korean Conference on Protein Folding: Theoretical and Experimental Approaches (year: 2021, pages: 14), Publisher: Wydział Chemii UG
    Date:
    conference 2021-09-17 - 2021-09-21
    Status:
    Published

  6. Characteristics of the relationship between amyloid-beta oligomers with Human Cystatin C

    Authors:
    Adriana Żyła, Anne Martel, Michał Taube, Przemysław Jurczak, Igor Zhukov, Aneta Szymańska, Maciej Kozak
    Conference:
    Synchrotron Radiation in Investigations of Condensed Matter (year: 2021, pages: 17), Publisher: ZIBJ Dubna
    Date:
    conference 2021-10-12 - 2021-10-13
    Status:
    Published

  7. Structural analysis and molecular dynamic processes in the human cystatin C at presence of human serum albumin (HSA) by means NMR spectroscopy

    Authors:
    I. Zhukov, A. Szymanska, P. Jurczak, W. Bal, M. Kozak
    Conference:
    44th FEBS Congress (year: 2019, pages: 277-288), Publisher: FEBS
    Date:
    conference 43652
    Status:
    Published

  8. Small angle X-ray scattering studies concerning the oligomerization of human cystatin C.

    Authors:
    Daria Wojciechowska, Michał Taube, Augustyn Moliński, Maciej Kozak
    Conference:
    International School and Symposium on Synchrotron Radiation in Natural Science (year: 2022, pages: -), Publisher: Polish Synchrotron Radiation Society
    Date:
    conference 22-25.08.2022
    Status:
    Published

  9. Molecular basis of selected neurodegenerative disorders – SAXS, SANS and MD studies

    Authors:
    Maciej Kozak, Adriana Żyła, Joanna Wolak, Aneta Szymańska, Maciej Gielnik, Michał Taube, Igor Zhukov, Kosma Szutkowski, Michał Nowakowski, Wojciech M. Kwiatek, A.I. Kuklin
    Conference:
    Konferencja międzynarodowa: 5th Polish-Korean Conference on Protein Folding: Theoretical and Experimental Approaches (year: 2019, pages: 17), Publisher: KIAS
    Date:
    conference 43724
    Status:
    Published

  10. Search for the perfect buffer - HCC oligomerization studies

    Authors:
    Daria Wojciechowska, Michał Taube, Maciej Kozak
    Conference:
    CYSTATINS 2022 (year: 2022, pages: 32), Publisher: Wydział Chemii UG
    Date:
    conference 16-18.06.2022
    Status:
    Published

  11. Structural and biophysical studies of the plant m6A methyltransferase complex

    Authors:
    M. Taube, I. Zhukov, K. Szutkowski, A. Jarmołowski, Z. Szweykowska-Kulinska, M. Kozak
    Conference:
    44th FEBS Congress (year: 2019, pages: 122), Publisher: FEBS
    Date:
    conference 43652
    Status:
    Published

  12. Structural insights into an amyloid beta aggregation in presence of human serum albumin and human cystatin C

    Authors:
    Adriana Żyła, Michał Taube, Maciej Kozak, Kosma Szutkowski, Wojciech Bal
    Conference:
    NANOTECH Poland (year: 2019, pages: 169), Publisher: NanoBioMed Centre
    Date:
    conference 43621
    Status:
    Published

  13. The Evidence of Cu2+ and Zn2+ Modulation of Key HSA, HCC, and Aβ Proteins Activity in Neurodegenerative Processes

    Authors:
    Wojciech M. Kwiatek, Michał Nowakowski, Joanna Wolak, Karolina Rucinska, Joanna Maksim, Michał Taube, Daria Wojciechowska, Ewa Banachowicz, Maciej Kozak
    Conference:
    Denver X-ray Conference - 72nd Annual Conference on Applications of X-ray Analysis (year: 2023, pages: 1), Publisher: DXC
    Date:
    conference 2023-08-07 - 2023-08-11
    Status:
    Published

  14. The Study of Selected Complexes of Human Serum Albumin with Amyloid Beta Peptides and Human Cystatin C

    Authors:
    Adriana Żyła, Michał Taube, Augustyn Molinski, Igor Zhukov, Alexander Kuklin, Aneta Szymanska, Maciej Kozak
    Conference:
    64th Annual Meeting of Biophysical Society (year: 2020, pages: 369A), Publisher: Cell Press
    Date:
    conference 2020-02-15 - 2020-02-19
    Status:
    Published
    DOI:
    link to the publication

  15. Conformational dynamics of human cystatin C - an extended view on the structure based on XAS, AFM, SAXS and SANS

    Authors:
    Maciej Kozak, Joanna Wolak, Daria Wojciechowska, Adriana Żyła, Augustyn Moliński, Michał Taube, Ewa Banachowicz, Anne Martel, Przemyslaw Jurczak, Aneta Szymanska, Michał Nowakowski
    Conference:
    Joint Meeting of the 20th KIAS Conference on Protein Structureand Function and The 7th Korean-Polish Conference on ProteinFolding: Theoretical and Experimental Approaches (year: 2022, pages: -), Publisher: KIAS
    Date:
    conference 14-17.09.2022
    Status:
    Published

  16. From disordered chain to fibrils SAXS and spectroscopic studies of protein fibrillation process

    Authors:
    Maciej Kozak, Maciej Gielnik, Michał Taube, Zuzanna Pietralik, Aneta Szymańska, Igor Zhukov, Michał Nowakowski, Wojciech Kwiatek
    Conference:
    Konferencja międzynarodowa: Fourth Polish-Korean Conference on Protein Folding: Theoretical and Experimental Approaches (year: 2018, pages: 27), Publisher: Wydział Chemii UG, Fundacja PERSPEKTYWA
    Date:
    conference 43352
    Status:
    Published

  17. Structural studies and characteristics of interaction between amyloid-beta peptides and associated protein human cystatin c

    Authors:
    Adriana Żyła, Anne Martel, Michał Taube, Przemysław Jurczak, Igor Zhukov, Aneta Szymańska, Maciej Kozak
    Conference:
    NanoTech Poland 2021 (year: 2021, pages: 171), Publisher: NanoBioMedical Centre AMU
    Date:
    conference 2021-05-09 - 2021-05-11
    Status:
    Published

  18. Influence of human serum albumin, human cystatin C and zinc ions on the amyloid  fibrilization process

    Authors:
    Joanna Wolak, Daria Wojciechowska, Augustyn Moliński, Maciej Kozak
    Conference:
    NanoTech Poland 2021 (year: 2021, pages: 169), Publisher: NanoBioMedical Centre AMU
    Date:
    conference 2021-05-09 - 2021-05-11
    Status:
    Published

  19. Interactions between amyloid-beta peptides,human serum albumin and human cystatin C studied by the use of X-ray and light scattering, NMR spectroscopy and bioinformatics

    Authors:
    Adriana Żyła, Aneta Szymańska, Joanna Wolak, Michał Taube, Daria Grobys, Ewa Banachowicz, Igor Zhokov, Maciej Kozak
    Conference:
    The Joint Meeting of the Polish Synchrotron Radiation Society and SOLARIS Users (year: 2020, pages: 98), Publisher: PTPS
    Date:
    conference 2020-09-09 - 2020-09-11
    Status:
    Published

  20. Structural investigation interaction between amyloid-beta peptides and associated proteins the human serum albumin and human cystatin C

    Authors:
    Adriana Żyła, Przemysław Jurczak, Aneta Szymańska, Joanna Wolak, Michał Taube, Igor Zhukov, Alexander I. Kuklin, Maciej Kozak
    Conference:
    Condensed Matter Reserach at the IBR-2 - International Conference (year: 2020, pages: 227), Publisher: JINR Dubna (Russia)
    Date:
    conference 2020-10-12 - 2020-10-16
    Status:
    Published

  21. Structural investigation of the amyloid aggregates in the presence of human serum albumin and human cystatin C

    Authors:
    Adriana Żyła, Augustyn Moliński, Michał Taube, Agnieszka Belczyk Ciesielska, Maciej Kozak, Wojciech Bal
    Conference:
    Konferencja międzynarodowa: Fourth Polish-Korean Conference on Protein Folding: Theoretical and Experimental Approaches (year: 2018, pages: 49), Publisher: Wydział Chemii UG, Fundacja PERSPEKTYWA
    Date:
    conference 43352
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski