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Information on the principal investigator and host institution

Information of the project and the call

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Role of autophagy and mitochondrial quality control mechanisms in the protective action of PGC-1alpha against oxidative stress-induced degeneration of aging retina

2017/27/B/NZ3/00872

Keywords:

senescence autophagy mitophagy retinal pigment epithelium oxidative stress

Descriptors:

  • NZ3_4:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Błasiak 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 032 500 PLN

Project start date (Y-m-d): 2018-09-14

Project end date (Y-m-d): 2023-09-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (16)
  • Articles in post-conference publications (4)
  1. Senescence in the Pathogenesis of Age-Related Macular Degeneration
    Authors:
    Blasiak J
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2020, tom: 77, strony: 789-805), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s00018-019-03420-x - link to the publication
  2. Autophagy in age-related macular degeneration
    Authors:
    Kai Kaarniranta, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky, Debasish Sinha
    Academic press:
    Autophagy (rok: 2023, tom: 19, strony: 388-400), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15548627.2022.2069437 - link to the publication
  3. The Aging Stress Response and Its Implication for AMD Pathogenesis
    Authors:
    JBlasiak J, Pawlowska E, Sobczuk A, Szczepanska J, Kaarniranta K
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 8840), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21228840 - link to the publication
  4. PGC-1α regulates the interplay between oxidative stress, senescence and autophagy in the aging retina important in age-related macular degeneration
    Authors:
    Gurubaran S, Watała C, Kostanek J, Szczepanska J, Pawlowska E, Kaarniranta K, Blasiak J
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2024, tom: 28, strony: e18051), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.18051 - link to the publication
  5. Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?
    Authors:
    Janusz Blasiak, Kai Kaarniranta
    Academic press:
    Expert Opinion on Therapeutic Targets (rok: 2022, tom: 26, strony: 883-895), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/14728222.2022.2157260 - link to the publication
  6. Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response
    Authors:
    Juha Hyttinen, Janusz Blasiak, Pasi Tavi & Kai Kaarniranta
    Academic press:
    Expert Opinion on Therapeutic Targets (rok: 2021, tom: bd, strony: bd), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/14728222.2021.1991913 - link to the publication
  7. PGC-1α regulates the interplay between oxidative stress, senescence and autophagy in the aging retina important in age-related macular degeneration
    Authors:
    Gurubaran S, Watała C, Kostanek J, Szczepanska J, Pawlowska E, Kaarniranta K, Blasiak J
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2024, tom: 28, strony: e18051), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.18051 - link to the publication
  8. Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)
    Authors:
    Kaarniranta K, Pawłowska E, Szczepańska J, Jabłkowska A, Błasiak J
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 2374), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20102374 - link to the publication
  9. Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration
    Authors:
    Blasiak J, Pawlowska E, Szczepanska J, Kaarniranta K
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: pi: E210), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20010210 - link to the publication
  10. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
    Authors:
    Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K
    Academic press:
    Redox Biology (rok: 2019, tom: 20, strony: 45677), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10,1016 - link to the publication
  11. Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1
    Authors:
    Janusz Blasiak,Joanna Szczepanska Janusz Blasiak, Michal Fila, Elzbieta Pawlowska, Kai Kaarniranta
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7194), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  12. Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
    Authors:
    Kaarniranta K, Uusitalo H, Błasiak J, Felszeghy S, Kannan R, Kauppinen A, Salminene A, Sinha D, Ferrington D
    Academic press:
    Progress in Retina and Eye Research (rok: 2020, tom: 79, strony: 100858), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD
    Status:
    Published
    DOI:
    10.1016/j.preteyeres.2020.100858 - link to the publication
  13. Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?
    Authors:
    Janusz Blasiak, Kai Kaarniranta
    Academic press:
    Expert Opinion on Therapeutic Targets (rok: 2022, tom: 26, strony: 883-895), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/14728222.2022.2157260 - link to the publication
  14. Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1a Double Knock-Out Mice
    Authors:
    Janusz Blasiak, Elzbieta Pawlowska, Elisa Toropainen, Juha M. T. Hyttinen, Johanna Viir, John E. Eriksson, Heping Xu, Szabolcs Felszeghy, Kai Kaarniranta
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1684), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041684 - link to the publication
  15. Interplay between aging and other factors of the pathogenesis of age-related macular degeneration
    Authors:
    Janusz Blasiak, Piotr Sobczuk, Elzbieta Pawlowska, Kai Kaarniranta
    Academic press:
    Ageing Research Reviews (rok: 2022, tom: 81, strony: 101735), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2022.101735 - link to the publication
  16. Interplay between aging and other factors of the pathogenesis of age-related macular degeneration
    Authors:
    Janusz Blasiak, Piotr Sobczuk, Elzbieta Pawlowska, Kai Kaarniranta
    Academic press:
    Ageing Research Reviews (rok: 2022, tom: 81, strony: 101735), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2022.101735 - link to the publication
  1. Oxidative stress induces mitochondrial dysfunction and autophagy in ARPE-19 cells
    Authors:
    Blasiak J, Barszczewska G, Gralewska P, Kaarniranta K
    Conference:
    2019 European Association for Vision and Eye Research Conference (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 17-19 października 2019
    Status:
    Published
  2. Peroxisome proliferator activated receptor alpha (PGC-1αα) regulates oxidative stress, cellular senescence and autophagy in the mouse retinal pigment epithelium
    Authors:
    Blasiak J, Gurubaran S, Kaarniranta K,
    Conference:
    Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), New Orleans LA (rok: 2023, ), Wydawca: ASSOC RESEARCH VISION OPHTHALMOLOGY INC12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606
    Data:
    konferencja 23-27 kwietnia 2023
    Status:
    Published
  3. Interplay between autophagy and mitochondrial metabolism in retinal pigment epithelium cells obtained by differentiation of induced pluripotent cells generated from wet AMD patients
    Authors:
    Janusz Blasiak, Ali Koskela, Tomi Toumainen, Heli Skottman, Pasi Tavi, Kai Kaarniranta
    Conference:
    2022 European Association for Vision and Eye Research Festival (rok: 2022, ), Wydawca: Wiley
    Data:
    konferencja 13-15 października 2022
    Status:
    Published
  4. Peroxisome Proliferator Activated Receptor Alpha Regulates Interplay between Senescence, Mitochondrial Functions and Autophagy in Retinal Cells
    Authors:
    J. Blasiak , M. Hytti , A. Koskela , S. Felszeghy , K. Kaarniranta
    Conference:
    American Society for Cell Biology and European Molecular Biology Organization Join Meeting, Dec. 3-7, 2022, Washington, DC, USA (rok: 2023, ), Wydawca: Molecular Biology of the Cell, American Society for Cell Biology
    Data:
    konferencja 3-7 grudnia 2022
    Status:
    Published

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