Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Phenotype of macrophages activated in vitro with biofilm bacteria isolated from cystic fibrosis lung infections. Evaluation of a regulatory and antibcterial role of M1 and M2 "trained" macrophages in inflammation associated with biofilm infections.

2017/27/B/NZ6/01772

Keywords:

biofilm cystic fibrosis chronic inflammation neutrophils trained macrophaages P. aeruginosa S. aureus innate immunity

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_4: Bacteriology
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Marcinkiewicz 

Number of co-investigators in the project: 20

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 638 200 PLN

Project start date (Y-m-d): 2018-07-13

Project end date (Y-m-d): 2023-07-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (7 499 PLN)
  2. Laptop.
  3. Mini vortex laboratoryjny (1 000 PLN)
  4. Mini wirówka.
  5. Spektrofotometr (Nanodrop) (30 000 PLN)
  6. Komora Laminarna (65 000 PLN)
  7. Lampa UV statywowa.
  8. Laptop (7 312 PLN)
  9. Mikroskop odwrócony (40 000 PLN)
  10. Mini vortex laboratoryjny.
  11. Wytrząsarka do mikropłytek i probówek (5 000 PLN)
  12. Komputer z oprogramowaniem.
  13. Monitor (850 PLN)
  14. Chemiluminometr (46 000 PLN)
  15. Dewary z wyposażeniem do przechowywania i transportu komórek w ciekłym azocie (20 000 PLN)
  16. Stacja do bezpiecznego usuwania nadsączy z hodowli. (10 000 PLN)
  17. Komputer z oprogramowaniem (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Chronic bacterial pulmonary infections in advanced cystic fibrosis differently affect the level of sputum neutrophil elastase, IL-8 and IL-6
    Authors:
    Grzegorz Majka, Henryk Mazurek , Magdalena Strus , Marta Ciszek-Lenda , Rafał Szatanek , Agnieszka Pac , Edyta Golińska , Janusz Marcinkiewicz
    Academic press:
    Clinical and Experimental Immunology (rok: 2021, tom: 205 (3), strony: 391-405), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/cei.13624 - link to the publication
  2. Pseudomonas aeruginosa biofilm is a potent inducer of phagocyte hyperinflammation.
    Authors:
    Ciszek-Lenda M, Strus M, Walczewska M, Majka G, Machul-Żwirbla A, Mikołajczyk D, Górska S, Gamian A, Chain B, Marcinkiewicz J
    Academic press:
    Inflammation Research (rok: 2019, tom: 68(5), strony: 397-413), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-019-01227-x - link to the publication
  3. Are patients with lung cystic fibrosis at increased risk of severe and fatal COVID-19? Interleukin 6 as a predictor of COVID-19 outcomes.
    Authors:
    Marcinkiewicz J, Mazurek H, Majka G, Chain B
    Academic press:
    Polish Archives of Internal Medicine (rok: 2020, tom: 130, strony: 919-920), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.15630 - link to the publication
  4. Cytokines as predictors of COVID-19 severity: evidence from a meta-analysis. Authors' reply
    Authors:
    Marcinkiewicz J, Majka G
    Academic press:
    Polish Archives of Internal Medicine (rok: 2021, tom: 131, strony: bd), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.15794 - link to the publication
  5. Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages.
    Authors:
    Marta Ciszek-Lenda, Grzegorz Majka, Maciej Suski, Maria Walczewska, Sabina Górska, Edyta Golińska, Angelika Fedor, Andrzej Gamian, Rafał Olszanecki, Magdalena Strus, Janusz Marcinkiewicz
    Academic press:
    Inflammation Reaserch (rok: 2023, tom: 72(6), strony: 1275-1289), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-023-01743-x. - link to the publication

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