Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of extracellular ATP fraction in induction of epithelial-mesenchymal transition - studies using analogs of nucleotide

2017/26/D/ST5/01046

Keywords:

ATP EMT nucleotide analogs

Descriptors:

  • NZ3_2: Cell physiology
  • ST5_16:
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Róża Pawłowska 

Number of co-investigators in the project: 3

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 675 500 PLN

Project start date (Y-m-d): 2018-04-19

Project end date (Y-m-d): 2023-04-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna (43 000 PLN)
  2. Inkubator hodowlany (25 000 PLN)
  3. System Vacusafe z pompą..
  4. notebook apple macbook.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (16)
  1. Highly fluorescent distyrylnaphthalene derivatives as a tool for visualization of cellular membranes
    Authors:
    Justyna Suwara, Beata Lukasik, Remigiusz Zurawinski, Roza Pawlowska, Arkadiusz Chworos
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 951), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13040951 - link to the publication
  2. Tissue-Nonspecific Alkaline Phosphatase (TNAP) as the Enzyme Involved in the Degradation of Nucleotide Analogues in the Ligand Docking and Molecular Dynamics Approaches
    Authors:
    Rafal Madaj, Bartlomiej Gostynski, Roza Pawlowska*, Arkadiusz Chworos*
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1104), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11081104 - link to the publication
  3. Visualization of Cellular Membranes in 2D and 3D Conditions Using a New Fluorescent Dithienothiophene S,S-Dioxide Derivative
    Authors:
    Aneta Rzewnicka, Jerzy Krysiak, Roza Pawłowska*, Remigiusz Zurawinski*
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(11), strony: 9620), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24119620 - link to the publication
  4. A novel route to a chiral building block for the preparation of cyclopentenyl carbocyclic nucleosides. Synthesis and anticancer activity of enantiomeric neplanocins A
    Authors:
    Beata Lukasik, Maciej Mikina, Marian Mikolajczyk, Roza Pawlowska, Remigiusz Zurawinski
    Academic press:
    RSC Advances (rok: 2020, tom: 10, strony: 31838–31847), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0ra06394k - link to the publication
  5. The ATP-dependent pathways and human diseases
    Authors:
    Justyna Suwara, Ewa Radzikowska-Cieciura, Arkadiusz Chworos, Roza Pawlowska*
    Academic press:
    Current Medicinal Chemistry (rok: 2023, tom: 30(11), strony: 1232-1255), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867329666220322104552 - link to the publication
  6. Modified Nucleotides for Chemical and Enzymatic Synthesis of Therapeutic RNA
    Authors:
    Anna Graczyk, Ewa Radzikowska-Cieciura, Renata Kaczmarek, Roza Pawlowska, Arkadiusz Chworos
    Academic press:
    Current Medicinal Chemistry (rok: 2023, tom: 30 (11), strony: 1320 - 1347), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867330666221014111403 - link to the publication
  1. The alpha-(di)thio and beta-gamma-phosphate modified ATP analogues - synthesis and hydrolytic stability
    Authors:
    Ewa Radzikowska-Cieciura, Julia Fastyn, Justyna Suwara, Anna Graczyk, Roza Pawlowska
    Conference:
    63 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2021, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 13-17.09.2021
    Status:
    Published
  2. The alpha-thio and beta-gamma-hypophosphate modified ATP analogs - synthesis and cytotoxicity
    Authors:
    Ewa Radzikowska-Cieciura, Roza Pawlowska, Dariusz Korczynski, Justyna Milczarek, Arkadiusz Chworos
    Conference:
    XXI International Symposium "Advances in the Chemistry of Heteroorganic Compounds" (rok: 2018, ), Wydawca: 21th International Symposium "Advances in the Chemistry of Heteroorganic Compounds"
    Data:
    konferencja 23.11.2018
    Status:
    Published
  3. The migration and invasiveness of cancer cells based on the fluorescent imaging techniques.
    Authors:
    Roza Pawlowska, Ewa Radzikowska, Justyna Milczarek and Arkadiusz Chworos
    Conference:
    SoftComp & EUSMI Annual Meeting (rok: 2018, ), Wydawca: SoftComp/EUSMI
    Data:
    konferencja 28-31.05.2018
    Status:
    Published
  4. ATP analogues as ligands for NPP1 protein - theoretical analysis
    Authors:
    Sepideh Jafari, Roza Pawlowska, Arkadiusz Chworos
    Conference:
    XIV Sesja Magistrantów i Doktorantów Łódzkiego Środowiska Chemików (rok: 2023, ), Wydawca: Wydawnictwo Uniwersytetu Łódzkiego
    Data:
    konferencja 13.06.2023
    Status:
    Published
  5. Extracellular ATP enhances migration and invasion properties of human squamous carcinoma cells
    Authors:
    Roza Pawlowska, Julia Fastyn, Justyna Suwara, Anna Graczyk, Ewa Radzikowska-Cieciura, Arkadiusz Chworos
    Conference:
    Cell Bio Virtual 2021 - An online American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO) Meeting (rok: 2021, ), Wydawca: The American Society for Cell Biology
    Data:
    konferencja 01-10.12.2021
    Status:
    Published
  6. Molecular docking study of selected ATP derivatives in complexes with P2X and P2Y receptors
    Authors:
    Rafal Madaj, Roza Pawlowska, Arkadiusz Chworos
    Conference:
    XXII International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2019, ), Wydawca: Advances in the Chemistry of Heteroorganic Compounds
    Data:
    konferencja 43791
    Status:
    Published
  7. The epithelial-mesenchymal transition of A431 cells after treatment with ATP, ADP, AMP and adenosine
    Authors:
    Roza Pawlowska, Julia Fastyn, Anna Graczyk, Ewa Radzikowska-Cieciura, Arkadiusz Chworos
    Conference:
    IUBMB-FEBS-PABMB 2022 Congress (rok: 2022, ), Wydawca: Wiley
    Data:
    konferencja 09 - 14.07.2022
    Status:
    Published
  8. The impact of the clodronate-based ATP analogues on the skin cancer cells
    Authors:
    Roza Pawlowska, Ewa Radzikowska-Cieciura, Julia Fastyn, Anna Graczyk, Arkadiusz Chworos
    Conference:
    EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine (rok: 2022, ), Wydawca: The European Association for Cancer Research (EACR)
    Data:
    konferencja 20 - 23.06.2022
    Status:
    Published
  9. The influence of ectonucleotidases expression on ATP-dependent extracellular signalling
    Authors:
    Justyna Suwara, Ewa Radzikowska-Cieciura, Rafal Madaj, Anna Graczyk, Roza Pawlowska
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: WILEY
    Data:
    konferencja 03-08.07.2021
    Status:
    Published
  10. Extracellular ATP increases migration of osteosarcoma MG-63 cells
    Authors:
    Roza Pawlowska, Justyna Suwara, Anna Graczyk, Julia Fastyn, Ewa Radzikowska-Cieciura, Arkadiusz Chworos
    Conference:
    18th Biennial Congress of the Metastasis Research Society (rok: 2021, ), Wydawca: Metastasis Research Society
    Data:
    konferencja 15 – 17.11.2021
    Status:
    Published
  11. The metabolism of extracellular adenosine-5'-triphosphate in breast cancer cells.
    Authors:
    Roza Pawlowska, Renata Kaczmarek, Ewa Radzikowska-Cieciura, Justyna Milczarek
    Conference:
    Metabolism in Cancer and Stromal Cells (2nd edition) (rok: 2018, ), Wydawca: VIB Conference Series
    Data:
    konferencja 26-27.11.2018
    Status:
    Published
  12. Therapeutic potential of thiophosphate ATP analogues for wound healing.
    Authors:
    Roza Pawlowska, Julia Fastyn, Ewa Radzikowska-Cieciura, Arkadiusz Chworos
    Conference:
    The 29th Young Researcher Fellows Meeting (rok: 2022, ), Wydawca: School of Pharmacy, Nantes University
    Data:
    konferencja 04 - 06.07.2022
    Status:
    Published
  13. ATP and its degradation products as important elements of tumor microenvironment
    Authors:
    Justyna Suwara, Rafal Madaj, Ewa Radzikowska-Cieciura, Roza Pawlowska
    Conference:
    The 5th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer (rok: 2020, ), Wydawca: Maria Sklodowska-Curie National Research Institute of Oncology
    Data:
    konferencja 23-24.09.2020
    Status:
    Published
  14. Clodronate-based ATP analogs as extracellular signaling molecules
    Authors:
    Justyna Suwara, Ewa Radzikowska-Cieciura, Arkadiusz Chworos, Roza Pawlowska
    Conference:
    XXII International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2019, ), Wydawca: Advances in the Chemistry of Heteroorganic Compounds
    Data:
    konferencja 43791
    Status:
    Published
  15. The adenosine carbocyclic analogue and its impact on human squamous carcinoma cells
    Authors:
    Roza Pawlowska, Justyna Suwara, Beata Lukasik, Remigiusz Zurawinski, Arkadiusz Chworos
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: WILEY
    Data:
    konferencja 03-08.07.2021
    Status:
    Published
  16. Wpływ tiofosforanowych analogów ATP na ludzkie keratynocyty
    Authors:
    Julia Fastyn, Roza Pawlowska, Edyta Gendaszewska-Darmach
    Conference:
    XIII Sesja Magistrantów i Doktorantów Łódzkiego Środowiska Chemików (rok: 2022, ), Wydawca: Wydawnictwo Politechniki Łódzkiej
    Data:
    konferencja 22.06.2022
    Status:
    Published

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