Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Role of TRIM28 multidomain protein in the maintenance of cancer stem cell population

2017/26/D/NZ3/00848

Keywords:

TRIM28 cancer stem cells pluripotency RING domain PHD domain

Descriptors:

  • NZ3_8: Stem cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Patrycja Czerwińska 

Number of co-investigators in the project: 2

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 1 284 055 PLN

Project start date (Y-m-d): 2018-06-04

Project end date (Y-m-d): 2025-12-03

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Bromodomain (BrD) family members as regulators of cancer stemness – a comprehensive review
    Authors:
    Czerwinska P, Mackiewicz AA
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24(2), strony: 995), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24020995 - link to the publication
  2. Melanoma Stem Cell-Like Phenotype and Significant Suppression of Immune Response within a Tumor Are Regulated by TRIM28 Protein
    Authors:
    Czerwinska P, Jaworska AM, Wlodarczyk NA, Mackiewicz AA
    Academic press:
    Cancers (Basel) (rok: 2020, tom: 12(10), strony: 2998-3018), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12102998 - link to the publication
  3. The Association between TIF1 Family Members and Cancer Stemness in Solid Tumors
    Authors:
    Czerwinska P, Wlodarczyk NA, Jaworska AM, Mackiewicz AA.
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 1528-1547), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13071528 - link to the publication
  4. The role of TRIM family proteins in the regulation of cancer stem cell self‐renewal
    Authors:
    Jaworska AM, Wlodarczyk NA, Mackiewicz A, Czerwinska P
    Academic press:
    Stem Cells (rok: 2020, tom: 38(2), strony: 165-173), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/stem.3109 - link to the publication
  5. Low Levels of TRIM28-Interacting KRAB-ZNF Genes Associate with Cancer Stemness and Predict Poor Prognosis of Kidney Renal Clear Cell Carcinoma Patients
    Authors:
    Czerwinska P, Mackiewicz AA
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13, strony: 4835-4854), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13194835 - link to the publication
  6. It Runs in the Bromodomain Family: Speckled Proteins (SP) Play a Role in the Antitumor Immune Response in Solid Tumors
    Authors:
    Rosochowicz MA, Lipowicz JM, Karwacka MI, Ostapowicz J, Cisek M, Mackiewicz AA, Czerwinska P
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24(1), strony: 549), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010549 - link to the publication
  7. Mining Transcriptomic Data to Uncover the Association between CBX Family Members and Cancer Stemness
    Authors:
    Czerwinska P, Mackiewicz AA
    Academic press:
    Int J Mol Sci (rok: 2022, tom: 23(21), strony: 13083), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232113083 - link to the publication
  8. The association between bromodomain proteins and cancer stemness in different solid tumor types
    Authors:
    Czerwinska P, Jaworska AM, Wlodarczyk NA, Cisek M, Karwacka M, Lipowicz J, Ostapowicz J, Rosochowicz M, Mackiewicz AA
    Academic press:
    Int J Cancer (rok: 2022, tom: 150(11), strony: 1838-1849), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/ijc.33937 - link to the publication

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