Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modifying motoneuron synaptic excitability with trans-spinal direct current stimulation (tsDCS) - A new method for amyotrophic lateral sclerosis (ALS) management ?

2017/26/D/NZ7/00728

Keywords:

Amyotrophic Lateral Sclerosis Synaptic excitation Synapses ALS Motoneuron Mouse SOD1 G93A

Descriptors:

  • NZ7_7: Rehabilitation
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu, Wydział Wychowania Fizycznego, Sportu i Rehabilitacji

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Bączyk 

Number of co-investigators in the project: 5

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 1 430 630 PLN

Project start date (Y-m-d): 2018-04-19

Project end date (Y-m-d): 2023-04-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kapnometr dla myszy (66 000 PLN)
  2. Respirator dla małych zwierząt, SAR-830/AP, CWE (34 000 PLN)
  3. Uchwyty kręgosłupowe dla myszy (35 000 PLN)
  4. moduł kontroli konta podejścia dla manipulatora IVM.
  5. Program komputerowy Spike2 (11 000 PLN)
  6. Przyśpieszająca karuzela RotaRod, z ekranem dotykowym, dla 5 myszy (30 000 PLN)
  7. Power1401-3 interfejs do pobierania danych (35 000 PLN)
  8. Programowalna pompa infuzyjna (2 szt.).
  9. Stół antywibracyjny z klatką Faradaya (45 200 PLN)
  10. Mikromanipulator (46 200 PLN)
  11. Stymulator i wzmacniacz sygnału wewnątrzkomórkowego (71 000 PLN)
  12. Wzmacniacz prądu zmiennego (11 000 PLN)
  13. Zestaw do anestezji gazowej u myszy VetFlo™ (20 000 PLN)
  14. Oscyloskop cyfrowy (3 szt.).
  15. Przenośny wyciąg oparów ACD Jumbo-VF Filtertrolley (11 000 PLN)
  16. System kontroli temperatury u myszy ACT2000 (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (2)
  1. Differential Effects of Invasive Anodal Trans-spinal Direct Current Stimulation on Monosynaptic Excitatory Postsynaptic Potentials, Ia Afferents Excitability, and Motoneuron Intrinsic Properties Between Superoxide Dismutase Type-1 Glycine to Alanine Substitution at Position 93 and Wildtype Mice
    Authors:
    Tomasz Jankowiak, Marcin Cholewiński, Marcin Bączyk
    Academic press:
    Neuroscience (rok: 2022, tom: 1,22083333333333, strony: 125-143), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2022.06.035 - link to the publication
  2. Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?
    Authors:
    Marcin Bączyk Piotr Krutki Daniel Zytnicki
    Academic press:
    Physiological Reports (rok: 2020, tom: 9(2), strony: e14706), Wydawca: The Physiological Society
    Status:
    Published
    DOI:
    10.14814/phy2.14706 - link to the publication
  3. Polaryzacja układu nerwowego - ciekawostka, doping, czy terapia?
    Authors:
    Marcin Bączyk
    Academic press:
    Kosmos (rok: 2020, tom: 69(4), strony: 623-630), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    10.36921/kos.2020_2720 - link to the publication
  1. Diversity of Mammalian Motoneurons and Motor Units
    Authors:
    Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki
    Book:
    Vertebrate Motoneurons (rok: 2022, tom: 28, strony: 131-150), Wydawca: Springer
    Status:
    Published
  2. From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerosis
    Authors:
    Marcin Bączyk, Marin Manuel, Francesco Roselli, Daniel Zytnicki
    Book:
    Vertebrate Motoneurons (rok: 2022, tom: 28, strony: 375-394), Wydawca: Springer
    Status:
    Published