Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Novel, two-stage delivery, nanohydroxyapatite (nHAP) - iron oxide (Fe2O3/Fe2O4) - miRNA scaffold with controlled by static magnetic field payload release for osteoporotic bone fracture regeneration.

2017/26/M/NZ5/01184

Keywords:

nanohydroxyapatite bone regeneration theranostic

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_9: Other related subjects
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Przyrodniczy we Wrocławiu

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Marycz 

Number of co-investigators in the project: 7

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 194 200 PLN

Project start date (Y-m-d): 2018-09-19

Project end date (Y-m-d): 2021-11-18

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (16)
  1. Hafnium (IV) oxide obtained by atomic layer deposition (ALD) technology promotes early osteogenesis via activation of Runx2-OPN-mir21A axis while inhibits osteoclasts activity
    Authors:
    A. Seweryn, Michalina Alicka, A. Fal, Katarzyna Kornicka-Garbowska, K. Lawniczak-Jablonska, M. Ozga, P. Kuzmiuk, M. Godlewski, Krzysztof Marycz
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 16), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1186/s12951-020-00692-5 - link to the publication
  2. Nanocrystalline Hydroxyapatite Loaded With Resveratrol in Colloidal Suspension Improves Viability, Metabolic Activity and Mitochondrial Potential in Human Adipose-Derived Mesenchymal Stromal Stem Cells (hASCs)
    Authors:
    Krzysztof Marycz, Agnieszka Smieszek, Justyna Trynda, Paulina Sobierajska, Sara Targonska, Lukasz Grosman , Rafal J Wiglusz
    Academic press:
    Polymers (rok: 2019, tom: 11, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym11010092 - link to the publication
  3. Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1
    Authors:
    Krzysztof Marycz , Agnieszka Smieszek, Klaudia Marcinkowska , Mateusz Sikora, Eliza Turlej , Paulina Sobierajska , Adrian Patej , Alina Bienko, Rafal J Wiglusz
    Academic press:
    International Journal of Nanomedicine (rok: 2021, tom: 18, strony: 28), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S303412 - link to the publication
  4. Novel Nanohydroxyapatite (nHAp)-Based Scaffold Doped with Iron Oxide Nanoparticles (IO), Functionalized with Small Non-Coding RNA (miR-21/124) Modulates Expression of Runt-Related Transcriptional Factor 2 and Osteopontin, Promoting Regeneration of Osteoporotic Bone in Bilateral Cranial Defects in a Senescence-Accelerated Mouse Model (SAM/P6). PART 2
    Authors:
    Krzysztof Marycz - Pierwszy autor, - Autor korespondencyjny Agnieszka Śmieszek Katarzyna Kornicka-Garbowska Ariadna Pielok Maciej Janeczek Anna Lipińska Anna Nikodem Jarosław Filipiak Paulina Sobierajska Jean-Marie Nedelec Rafał J. Wiglusz
    Academic press:
    International journal of nanomedicine (rok: 2021, tom: 16, strony: 17), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S316240 - link to the publication
  5. Small and Long Non-coding RNAs as Functional Regulators of Bone Homeostasis, Acting Alone or Cooperatively
    Authors:
    Mateusz Sikora, Krzysztof Marycz, Agnieszka Śmieszek
    Academic press:
    Molecular Therapy-Nucleic Acids (rok: 2020, tom: 21, strony: 792-803), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.omtn.2020.07.017 - link to the publication
  6. Co0.5Mn0.5Fe2O4@PMMA Nanoparticles Promotes Preosteoblast Differentiation through Activation of OPN-BGLAP2-DMP1 Axis and Modulates Osteoclastogenesis under Magnetic Field Conditions
    Authors:
    y Krzysztof Marycz, Eliza Turlej , Katarzyna Kornicka-Garbowska , Emilia Zachanowicz, Anna Tomaszewska, Magdalena Kulpa-Greszta, Robert Pązik
    Academic press:
    Materials (rok: 2021, tom: 14, strony: 20), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma14175010 - link to the publication
  7. Fe3O4 Magnetic Nanoparticles Under Static Magnetic Field Improve Osteogenesis via RUNX-2 and Inhibit Osteoclastogenesis by the Induction of Apoptosis
    Authors:
    Krzysztof Marycz, Paulina Sobierajska, Rafał J. Wiglusz, Rafał Idczak, Jean-Marie Nedelec, Andrzej Fal, Katarzyna Kornicka-Garbowska
    Academic press:
    International journal of nanomedicine (rok: 2020, tom: 15, strony: 22), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S256542 - link to the publication
  8. Lithium Ions (Li +) and Nanohydroxyapatite (nHAp) Doped With Li + Enhance Expression of Late Osteogenic Markers in Adipose-Derived Stem Cells. Potential Theranostic Application of nHAp Doped With Li + and Co-Doped With Europium (III) and Samarium (III) Ions
    Authors:
    M Alicka , P Sobierajska , K Kornicka, R J Wiglusz, K Marycz
    Academic press:
    Materials Science and Engineering: C Materials for Biological Applications (rok: 2019, tom: 99, strony: 1257-1273), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.02.073 - link to the publication
  9. Promotion Through External Magnetic Field of Osteogenic Differentiation Potential in Adipose-Derived Mesenchymal Stem Cells: Design of Polyurethane/Poly(lactic) Acid Sponges Doped With Iron Oxide Nanoparticles
    Authors:
    Krzysztof Marycz, Michalina Alicka, Katarzyna Kornicka‐Garbowska, Joanna Polnar, Anna Lis‐Bartos, Rafał J. Wiglusz, Michael Roecken, Jean‐Marie Nedelec
    Academic press:
    Journal of Biomedical Materials Research PART B APPLIED MATERIALS (rok: 2019, tom: 2019, strony: 45305), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/jbm.b.34488 - link to the publication
  10. Titanium Dioxide Thin Films Obtained by Atomic Layer Deposition Promotes Osteoblasts' Viability and Differentiation Potential While Inhibiting Osteoclast Activity - Potential Application for Osteoporotic Bone Regeneration
    Authors:
    Agnieszka Śmieszek, Aleksandra Seweryn, Klaudia Marcinkowska, Mateusz Sikora, Krystyna Lawniczak-Jablonska, Bartłomiej S. Witkowski, Piotr Kuzmiuk, Marek Godlewski, Krzysztof Marycz
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 20), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13214817 - link to the publication
  11. Zirconium Oxide Thin Films Obtained by Atomic Layer Deposition Technology Abolish the Anti-Osteogenic Effect Resulting from miR-21 Inhibition in the Pre-Osteoblastic MC3T3 Cell Line
    Authors:
    Seweryn A, Pielok A, Lawniczak-Jablonska K, Pietruszka R, Marcinkowska K, Sikora M, Witkowski BS, Godlewski M, Marycz K, Smieszek A
    Academic press:
    International Journal of Nanomedicine (rok: 2020, tom: 2020, strony: 1595—1610), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S237898 - link to the publication
  12. Bone marrow stromal cells (BMSCs CD45-/CD44+/CD73+/CD90+) isolated from osteoporotic mice SAM/P6 as a novel model for osteoporosis investigation
    Authors:
    Mateusz Sikora, Agnieszka Śmieszek, Krzysztof Marycz
    Academic press:
    Journal of cellular and molecular medicine (rok: 2021, tom: 25, strony: 18), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jcmm.16667 - link to the publication
  13. Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action
    Authors:
    K. Marycz, P. Sobierajska, M. Roecken, K. Kornicka-Garbowska, M. Kępska, R. Idczak, J.-M. Nedelec & R. J. Wiglusz
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 45315), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1186/s12951-020-00590-w - link to the publication
  14. The Role of miR-21 in Osteoblasts-Osteoclasts Coupling In Vitro
    Authors:
    Agnieszka Smieszek , Klaudia Marcinkowska , Ariadna Pielok, Mateusz Sikora, Lukas Valihrach , Krzysztof Marycz
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9020479 - link to the publication
  15. Theranostic Applications of Nanostructured Silicate-Substituted Hydroxyapatite Codoped with Eu3+and Bi3+Ions—A Novel Strategy for Bone Regeneration
    Authors:
    Sara Targońska, Mateusz Sikora, Krzysztof Marycz, Agnieszka Śmieszek, Rafal J. Wiglusz
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2020, tom: 6, strony: 6148–6160), Wydawca: ACS publications
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.0c00824 - link to the publication
  16. Three dimensional (3D) printed polylactic acid with nano-hydroxyapatite doped with europium(III) ions (nHAp/PLLA@Eu3+) composite for osteochondral defect regeneration and theranostics
    Authors:
    Krzysztof Marycz, Agnieszka Smieszek , Sara Targonska , Susan A Walsh, Konrad Szustakiewicz , Rafal J Wiglusz
    Academic press:
    Materials Science and Engineering C: Materials for Biological Applications (rok: 2020, tom: 110, strony: 12785), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.110634 - link to the publication

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