Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The mechanisms of hypotensive effectiveness of a stable analogue of 14,15-epoksyeicosatrienoic acid: EET-A

2017/26/M/NZ5/00367

Keywords:

Hypertension epoxyeicosatrienoic acids: EETs end-stage organ damage

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Kompanowska-Jezierska 

Number of co-investigators in the project: 5

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 200 000 PLN

Project start date (Y-m-d): 2018-04-27

Project end date (Y-m-d): 2022-01-26

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Effects of renal nerves and plasma EETs on blood pressure, renal hemodynamics and excretion in spontaneously hypertensive rats
    Authors:
    Agnieszka Walkowska, Olga Gawryś , Luděk Červenka , Elżbieta Kompanowska-Jezierska
    Academic press:
    Nitric Oxide , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats
    Authors:
    Agnieszka Walkowska, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski and Elżbieta Kompanowska-Jezierska
    Academic press:
    Frontiers in Physiology (rok: 2021, tom: 12, strony: 622882), Wydawca: www.frontiers.org
    Status:
    Published
    DOI:
    10.3389/fphys.2021.622882 - link to the publication
  3. Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats
    Authors:
    Iwona Baranowska, Olga Gawrys, Agnieszka Walkowska, Krzysztof H Olszynski, Luděk Červenka, John R Falck, Adeniyi M Adebesin, John D Imig, Elżbieta Kompanowska-Jezierska
    Academic press:
    Frontiers in Pharmacology (rok: 2022, tom: 12, strony: 798642), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fphar.2021.798642 - link to the publication
  4. Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats
    Authors:
    Gawrys, Olgaa,∗; Husková, Zuzanab,∗; Baranowska, Iwona; Walkowska, Agnieszka; Sadowski, Janusz; Kikerlová, Soňa; Vaňourková, Zdeňka; Honetschlägerová, Zuzana; Škaroupková, Petra; Červenka, Luděk; Falck, John Rd; Imig, John D.; Kompanowska-Jezierska, Elzbieta
    Academic press:
    Journal of Hypertension (rok: 2020, tom: 38(8), strony: 1802-1810), Wydawca: Wolters Kluwer Health, Inc.
    Status:
    Published
    DOI:
    10.1097/HJH.0000000000002462 - link to the publication
  1. Acute hypotensive effect of EET‐A, a stable analog of epoxyeicosatrienic acid (EET), in spontaneously hypertensive rats: dependence on endogenous EETs activity
    Authors:
    Agnieszka Walkowska Janusz Sadowski Ludek Cervenka John R. Falck Elzbieta Kompanowska-Jezierska
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: Federation of American Societies for Experimental Biology
    Data:
    konferencja 2020-04-4-7
    Status:
    Published
    DOI:
    link to the publication
  2. Treatment of hypertension with stable analogue of 14,15-Epoxyeicosatrienoic Acid (EET-A) in Spontaneously Hypertensive Rats
    Authors:
    Iwona Baranowska, Olga Gawryś, Agnieszka Walkowska, Zuzana Huskova, Zuzana Honetshlagerova, Ludek Cervenka, John Falck and Elzbieta Kompanowska-Jezierska
    Conference:
    Experimental Biology 2019 (rok: 2019, ), Wydawca: Federation of American Societies for Experimental Biology
    Data:
    konferencja 2019-04-6-9
    Status:
    Published
  3. Hypotensive efficiency of epoxyeicosatrienoic acid analog (EET-A) and 20-HETE agonist (AAA) in spontaneously hypertensive rats (SHR).
    Authors:
    Baranowska I, Gawryś O, Walkowska A, Huskova Z, Honetschlagerova Z, Falck JR, Imig JD, Cervenka L, Kompanowska-Jezierska E
    Conference:
    XXVIII Congress of the Polish Physiological Society "FROM DIVERSITY IN PHYSIOLOGY TO INTERDISCIPLINARY COOPERATION" (rok: 2021, ), Wydawca: Polish Physiological Society
    Data:
    konferencja 15-17.09.2021
    Status:
    Published
    DOI:
    link to the publication
  4. Effective Antihypertensive Treatment with Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Antagonist (AAA) of Spontaneously Hypertensive Rats (SHR)
    Authors:
    Olga Gawrys, Agnieszka Walkowska, Elzbieta Kompanowska-Jezierska, Zuzana Huskova, Zuzana Honetschlägerová, John Falck, John D Imig, Ludĕk Cervenka
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: Federation of American Societes for Experimental Biology
    Data:
    konferencja 2020-04-4-7
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy