Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Metallophores - understanding (and lighting up) metal transport in pathogens to help the host trick the invaders

2017/26/A/ST5/00363

Keywords:

siderophores zincophores metallophores physico-chemical methods of analysis

Descriptors:

  • ST5_16:
  • ST5_14: Other related subjects
  • ST5_24:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Henryk Kozłowski 

Number of co-investigators in the project: 9

Call: MAESTRO 9 - announced on 2017-06-14

Amount awarded: 3 513 200 PLN

Project start date (Y-m-d): 2018-04-17

Project end date (Y-m-d): 2025-04-16

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (25)
  • Book publications / chapters in book publications (3)
  1. Cu(II) induced re-structuring of ZnuD, a Zn(II) transporter from Neisseria meningitidis
    Authors:
    Aleksandra Hecel, Magdalena Rowińska-Żyrek, Henryk Kozłowski
    Academic press:
    Inorganic Chemistry (rok: 2019, tom: 58, strony: 5932-5942), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b00265 - link to the publication
  2. Cyclic analogs of desferrioxamine E siderophore for 68Ga nuclear imaging: coordination chemistry and biological activity in staphylococcus aureus
    Authors:
    Mular Andrzej, Shanzer Abraham, Kozłowski Henryk, Hubmann Isabella, Misslinger Matthias, Krzywik Julia, Decristoforo Clemens, Gumienna-Kontecka Elżbieta
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 17846-17857), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c02453 - link to the publication
  3. Fe(II), Mn(II), and Zn(II) Binding to the C‑Terminal Region of FeoB Protein: An Insight into the Coordination Chemistry and Specificity of the Escherichia coli Fe(II) Transporter
    Authors:
    Bartosz Orzel, Alessio Pelucelli, Malgorzata Ostrowska, Slawomir Potocki, Henryk Kozlowski, Massimiliano Peana, and Elzbieta Gumienna-Kontecka
    Academic press:
    Inorganic Chemistry (rok: 2023, tom: 62, strony: 18607−18624), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c02910 - link to the publication
  4. How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores
    Authors:
    Bellotti Denise, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Current Medicinal Chemistry (rok: 2021, tom: 28, strony: 7312-7338), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389200222666210514012945 - link to the publication
  5. Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules
    Authors:
    Wątły Joanna, Miller Adriana, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2021, tom: 217, strony: 111386), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2021.111386 - link to the publication
  6. Pneumococcal HxxHxH triad – copper(II) interactions – How important is the 'x'?
    Authors:
    Sławomir Potocki, Paula Delgado, Dorota Dudek,Anna Janicka-Kłos,Henryk Kozłowski, Magdalena Rowińska-Żyrek
    Academic press:
    Inorganica Chimica Acta (rok: 2019, tom: 488, strony: 255-259), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2019.01.029 - link to the publication
  7. Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+ binding?
    Authors:
    Adriana Miller, Dorota Dudek, Sławomir Potocki, Hanna Czapor-Irzabek, Henryk Kozłowski, Magdalena Rowińska-Żyrek
    Academic press:
    Metallomics (rok: 2018, tom: 10, strony: 1631-1637), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c8mt00275d - link to the publication
  8. Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides
    Authors:
    Wątły Joanna, Hecel Aleksandra, Wieczorek Robert, Rowińska-Żyrek Magdalena, Kozłowski Henryk
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 14247-14251), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c02584 - link to the publication
  9. The diversity and utility of arylthiazoline and aryloxazoline siderophores: challenges of total synthesis
    Authors:
    Kamińska Karolina, Mular Andrzej, Olshvang Evgenia, Metzler Nolte Nils, Kozłowski Henryk, Wojaczyńska Elżbieta, Gumienna-Kontecka Elżbieta
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 25284-25322), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2ra03841b - link to the publication
  10. Thermodynamic stability and speciation of Ga(III) and Zr(IV) complexes with high-denticity hydroxamate chelators
    Authors:
    Toporivska Yuliya, Mular Andrzej, Piasta Karolina, Ostrowska Małgorzata, Illuminati Davide, Baldi Andrea, Albanese Valentina, Pacifico Salvatore, Fritsky Igor O., Remelli Maurizio, Guerrini Remo, Gumienna-Kontecka Elżbieta
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 13332-13347), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c01622 - link to the publication
  11. Metal coordination to solute binding proteins – exciting chemistry with potential biological meaning
    Authors:
    Kinga Garstka, Denise Bellotti, Joanna Wątły, Henryk Kozłowski, Maurizio Remelli, Magdalena Rowińska-Żyrek
    Academic press:
    Dalton Transactions (rok: 2023, tom: 52, strony: 16140-16150), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d3dt02417b - link to the publication
  12. The diversity and utility of arylthiazoline and aryloxazoline siderophores: Challenges of coordination chemistry, biological activity and selected applications
    Authors:
    Mular Andrzej, Piasta Karolina, Jedyńczuk Aleksandra, Kamińska Karolina, Olshvang Evgenia, Metzler Nolte Nils, Wojaczyńska Elżbieta, Kozłowski Henryk, Gumienna-Kontecka Elżbieta
    Academic press:
    Coordination Chemistry Reviews (rok: 2024, tom: 501, strony: 215551/1-215551/40), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2023.215551 - link to the publication
  13. Thermodynamic surprises of Cu(II)-amylin analogue complexes in membrane mimicking solutions
    Authors:
    Dzień Emilia, Dudek Dorota, Witkowska Danuta, Rowińska-Żyrek Magdalena
    Academic press:
    Scientific Reports, 2022, 12, (rok: 2022, tom: 12, strony: 425/1-425/9), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-04197-5 - link to the publication
  14. Metal complexes of two specific regions of ZnuA, a periplasmic zinc(II) transporter from Escherichia coli
    Authors:
    Hecel Aleksandra, Kola Arian, Valensin Daniela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2020, tom: 59, strony: 1947-1958), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b03298 - link to the publication
  15. Metal specificity of the Ni(II) and Zn(II) binding sites of the N-terminal and G-domain of E. coli HypB
    Authors:
    Hecel Aleksandra, Kola Arian, Valensin Daniela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2021, tom: 50, strony: 12635-12647), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d1dt02126e - link to the publication
  16. The N-terminal domain of Helicobacter pylori's Hpn protein: The role of multiple histidine residues
    Authors:
    Bellotti Denise, Sinigaglia Angelica, Guerrini Remo, Marzola Erika, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2021, tom: 214, strony: 111304/1-111304/12), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2020.111304 - link to the publication
  17. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter of Candida albicans
    Authors:
    Bellotti Denise, Miller Adriana, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 121/1-121/16), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12010121 - link to the publication
  18. –HH and –HAAAH motifs act as fishing nets for biologically relevant metal ions in metallopeptides
    Authors:
    Aleksandra Hecel, Kinga Garstka, Henryk Kozłowski, Magdalena Rowińska-Żyrek
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2024, tom: 252, strony: 112456-112470), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2023.112456 - link to the publication
  19. Aspergillus fumigatus ZrfC Zn(II) transporter scavengers zincophore-bound Zn(II)
    Authors:
    Garstka Kinga, Potoczniak Gabriela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2024, tom: 53, strony: 2848-2858), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d3dt04083f - link to the publication
  20. Novel insights into the metal binding ability of ZinT periplasmic protein from Escherichia coli and Salmonella enterica
    Authors:
    Bellotti Denise, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Dalton Transactions (rok: 2020, tom: 49, strony: 9393-9403), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d0dt01626h - link to the publication
  21. Specific Zn(II)-binding site in the C-terminus of Aspf2, a zincophore from Aspergillus fumigatus
    Authors:
    Garstka Kinga, Hecel Aleksandra, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Metallomics (rok: 2022, tom: 14, strony: mfac042), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/mtomcs/mfac042 - link to the publication
  22. Uncapping the N-terminus of an ubiquitous His-tag peptide enhances its Cu2+ binding affinity
    Authors:
    Wątły Joanna, Hecel Aleksandra, Wieczorek Robert, Świątek-Kozłowska Jolanta, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2019, tom: 48, strony: 13567-13579), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c9dt01635j - link to the publication
  23. A comparative study on nickel binding to Hpn-like polypeptides from two Helicobacter pylori strains
    Authors:
    Witkowska Danuta, Szebesczyk Agnieszka, Wątły Joanna, Braczkowski Michał, Rowińska-Żyrek Magdalena
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 13210/1-13210/15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222413210 - link to the publication
  24. CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
    Authors:
    Kinga Garstka, Valentyn Dzyhovskyi, Joanna Wątły, Kamila Stokowa-Sołtys, Jolanta Świątek-Kozłowska, Henryk Kozłowski, Miquel Barceló-Oliver, Denise Bellotti, Magdalena Rowińska-Żyrek
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 3983-3997), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28103985 - link to the publication
  25. Zinc(II)—the overlooked éminence grise of chloroquine's fight against COVID-19?
    Authors:
    Hecel Aleksandra, Ostrowska Małgorzata, Stokowa-Sołtys Kamila, Wątły Joanna, Dudek Dorota, Miller Adriana, Potocki Sławomir, Matera-Witkiewicz Agnieszka, Domínguez-Martín Alicia, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Pharmaceuticals (rok: 2020, tom: 13, strony: 228/1-228/29), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph13090228 - link to the publication
  1. BUILDING A TROJAN HORSE: SIDEROPHORE-DRUG CONJUGATES FOR THE TREATMENT OF INFECTIOUS DISEASES
    Authors:
    Elżbieta Gumienna-Kontecka, Peggy Carver
    Book:
    Metal Ions in Life Sciences (rok: 2019, tom: 19, strony: 181-202), Wydawca: De Gruyter
    Status:
    Published
  2. Oddziaływanie przeciwdrobnoustrojowych peptydów z jonami metali - Relacja między chemią koordynacyjną, strukturą, termodynamiką a sposobem działania
    Authors:
    Dudek Dorota, Garstka Kinga, Miller Adriana, Dzień Emilia, Wątły Joanna, Hecel Aleksandra, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Book:
    Wiadomości Chemiczne (rok: 2022, tom: 76, strony: 365-391), Wydawca: Wiadomości Chemiczne
    Status:
    Published
  3. Homeostaza jonów Zn(II) w chorobach infekcyjnych = Homeostasis of Zn(II) ions in infectious diseases
    Authors:
    Błaszczok Aneta, Gumienna-Kontecka Elżbieta
    Book:
    Wiadomości Chemiczne (rok: 2021, tom: 75, strony: 271-291), Wydawca: Wiadomości Chemiczne
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy