Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Dual-function tail phage proteins- determination of the function and the mechanism of action towards (poly)saccharides

2017/26/E/NZ1/00249

Keywords:

bacteriophage tail tubular protein polysaccharide fiber protein biofilm enzymes

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Brzozowska 

Number of co-investigators in the project: 7

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 1 511 900 PLN

Project start date (Y-m-d): 2018-05-18

Project end date (Y-m-d): 2022-12-17

Project duration:: 55 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Diuar do przechowywania kryształów (10L).
  2. Komputer wraz z oprogramowaniem (2 szt.) (10 000 PLN)
  3. System do szybkiej chromatografii cieczowej białek - FPLC wraz z komputerem i programem do obsługi (300 000 PLN)
  4. Wytrząsarka płytek z wyposażeniem.
  5. Miernik gęstości optycznej.
  6. blok grzejny typu łaźnia wodna.
  7. Diuar do transportu kryształów makrocząsteczek.
  8. mikroskop stereoskopowy z wyposażeniem.
  9. pompa próżniowa.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. Biochemical features of the novel Tail Tubular Protein A of Yersinia phage phiYeO3-12
    Authors:
    Anna Pyra, Natalia Urbańska, Karolina Filik, Katherine Tyrlik & Ewa Brzozowska
    Academic press:
    Scientific Reports (rok: 2020, tom: -, strony: 10(1), 4196), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-61145-5 - link to the publication
  2. New Insights on the Feature and Function of Tail Tubular Protein B and Tail Fiber Protein of the Lytic Bacteriophage φYeO3-12 Specific for Yersinia enterocolitica Serotype O:3
    Authors:
    Anna Pyra,Karolina Filik,Bożena Szermer-Olearnik, Anna Czarny, Ewa Brzozowska
    Academic press:
    Molecules (rok: 2020, tom: 25(19), strony: 4392), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25194392 - link to the publication
  3. The Podovirus ϕ80-18 Targets the Pathogenic American Biotype 1B Strains of Yersinia enterocolitica
    Authors:
    Karolina Filik, Bożena Szermer-Olearnik, Maciej Wernecki, Lotta J. Happonen, Maria I. Pajunen, Ayesha Nawaz, Muhammad Suleman Qasim, Jin Woo Jun Laura Mattinen, Mikael Skurnik and Ewa Brzozowska
    Academic press:
    Frontiers in Microbiology (rok: 2020, tom: 11, strony: 1356), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fmicb.2020.01356 - link to the publication
  4. Bacteriophage Tail Proteins as a Tool for Bacterial Pathogen Recognition—A Literature Review
    Authors:
    Filik, K.; Szermer-Olearnik, B.; Oleksy, S.; Brykała, J.; Brzozowska, E.
    Academic press:
    Antibiotics (rok: 2022, tom: 11, strony: 555), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antibiotics11050555 - link to the publication
  5. In silico analysis of bacteriophage tail tubular proteins suggests a putative sugar binding site and a catalytic mechanism
    Authors:
    Wiesław Świętnicki Ewa Brzozowska
    Academic press:
    Journal of Molecular Graphics and Modelling (rok: 2019, tom: 92, strony: 45520), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmgm.2019.07.002 - link to the publication
  6. φYeO3-12 phage tail fiber Gp17 as a promising high specific tool for recognition of Yersinia enterocolitica pathogenic serotype O:3
    Authors:
    Karolina Filik, Bożena Szermer-Olearnik, Joanna Niedziółka-Jönson, Ewa Roźniecka, Jarosław Ciekot, Anna Pyra, Irwin Matyjaszczyk, Mikael Skurnik & Ewa Brzozowska
    Academic press:
    AMB Express (rok: 2021, tom: 12, strony: 1), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s13568-021-01341-2 - link to the publication
  1. Characteristic of bacteriophage phi80-18 infecting Yersinia enterocolitica
    Authors:
    Bożena Szermer-Olearnik, Karolina Filik , Anna Wróblewska , Karolina Kichler , Ewa Brzozowska
    Conference:
    4 th International Wroclaw Scientific Meetings (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Tygiel Sp. z o.o.
    Data:
    konferencja 09-10.10
    Status:
    Published
  2. Dual-function tail tubular proteins of bacteriophages
    Authors:
    Anna Pyra, Karolina Filik, Ewa Brzozowska
    Conference:
    Joint Polish-German Crystallographic Meeting (rok: 2020, ), Wydawca: Walter de Gruyter GmbH & Co KG, 2020
    Data:
    konferencja 24-27.02
    Status:
    Published
  3. Badanie funkcji białek bakteriofagowych ze szczególnym uwzględnieniem zdolności do biodegradacji biofilmu
    Authors:
    Karolina Filik, Bożena Szermer-Olearnik, Jan Brykała, Ewa Brzozowska
    Conference:
    Multiomika III KONFERENCJA SZKOLENIOWA "MULTI-OMIKA – BIOLOGIA SYSTEMÓW W BADANIACH MEDYCZNYCH" (rok: 2019, ), Wydawca: Wydział Lekarski Uniwersytetu Medycznego
    Data:
    konferencja 28.XI
    Status:
    Published