Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New usnic acid derivatives as anticancer therapeutics

2017/26/M/NZ7/00668

Keywords:

cell death antiproliferative potential cancer cells chemical synthesis lichens

Descriptors:

  • NZ3_1: Cell biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anna Herman-Antosiewicz 

Number of co-investigators in the project: 7

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 260 000 PLN

Project start date (Y-m-d): 2018-04-12

Project end date (Y-m-d): 2023-10-11

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Correction to synthesis of usnic acid derivatives and evaluation of their antiproliferative activity against cancer cells
    Authors:
    Agnieszka Pyrczak-Felczykowska, Rajeshwar Narlawar, Anna Pawlik, Beata Guzow-Krzemińska, Damian Artymiuk, Aleksandra Hać, Kamil Ryś, Louis M. Rendina Tristan A. Reekie Anna Herman-Antosiewicz, Michael Kassiou
    Academic press:
    Journal of Natural Products (rok: 2020, tom: 83, strony: 563-564), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jnatprod.0c00129 - link to the publication
  2. Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells
    Authors:
    Gunawan G.A. , Gimła M. , Gardiner M.G. , Herman-Antosiewicz A. , Reekie T.A.
    Academic press:
    Bioorganic and Medical Chemistry (rok: 2023, tom: 79, strony: 45303), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.bmc.2023.117157 - link to the publication
  3. Synthesis of usnic acid derivatives and evaluation of their antiproliferative activity against cancer cells
    Authors:
    Agnieszka Pyrczak-Felczykowska, Rajeshwar Narlawar, Anna Pawlik, Beata Guzow-Krzemińska, Damian Artymiuk, Aleksandra Hać, Kamil Ryś, Louis M. Rendina, Tristan A. Reekie, Anna Herman-Antosiewicz, Michael Kassiou
    Academic press:
    Journal of Natural Products (rok: 2019, tom: 82, strony: 1768-1778), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jnatprod.8b00980 - link to the publication
  4. The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo
    Authors:
    Mariola Gimła, Agnieszka Pyrczak‑Felczykowska, Marcelina Malinowska, Aleksandra Hać, Magdalena Narajczyk, Irena Bylińska, Tristan A. Reekie and Anna Herman‑Antosiewicz
    Academic press:
    Cancer Cell International (rok: 2023, tom: 23, strony: 45304), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12935-023-03054-x - link to the publication
  5. The Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death
    Authors:
    Agnieszka Pyrczak-Felczykowska, Tristan A. Reekie, Marcin Jąkalski, Aleksandra Hać, Marcelina Malinowska, Anna Pawlik, Kamil Ryś, Beata Guzow-Krzemińska, Anna Herman-Antosiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1802-1821), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms23031802 - link to the publication
  6. Usnic acid derivatives as cytotoxic agents against cancer cells and the mechanisms of their activity
    Authors:
    Beata Guzow-Krzemińska, Katarzyna Krzemińska, Anna Herman-Antosiewicz
    Academic press:
    Current Pharmacology Reports (rok: 2019, tom: 5, strony: 429-439), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s40495-019-00202-8 - link to the publication

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