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The involvement of flavonoids on the development of pregnacy - induced hypertension in in vitro and in vivo studies

2017/25/B/NZ7/02741

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Włókien Naturalnych i Roślin Zielarskich

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Agnieszka Seremak-Mrozikiewicz

Number of co-investigators in the project: 10

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
864 947 PLN
Project start date
2018-02-22
Project end date
2021-02-21
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do pośredniego pomiaru ciśnienia skurczowego i rozkurczowego oraz akcji serca u szczurów przytomnych wraz z akcesoriami z wykorzystaniem telemetrii. Cost: 80 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Combined effects of methyldopa and flavonoids on the expression of selected factors related to inflammatory processes and vascular diseases in human placenta cells - an in vitro study

    Authors:
    Bogacz Anna, Mikołajczak Przemysław Ł., Wołek Marlena, Górska Aleksandra, Szulc Michał, Ożarowski Marcin, Kujawski Radosław, Czerny Bogusław, Wolski Hubert, Karpiński Tomasz M., Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Molecules (year: 2021, volume: 26(5), pages: 1259(1-20)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26051259 – link to the publication

  2. Plant phenolics and extracts in animal models of preeclampsia and clinical trials - review of perspectives for novel therapies

    Authors:
    Ożarowski Marcin, Karpiński Tomasz M., Szulc Michał, Wielgus Karolina, Kujawski Radosław, Wolski Hubert, Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Pharmaceuticals (year: 2021, volume: 14(3), pages: 269), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14030269 – link to the publication

  3. In vitro and in vivo activities of flavonoids - apigenin, baicalin, chrysin, scutellarin - in regulation of hypertension - a review for their possible effects in pregnancy-induced hypertension

    Authors:
    Ożarowski M, Kujawski R, Mikołajczak PŁ, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A.
    Academic press:
    Herba Polonica (year: 2019, volume: 65(1), pages: 55-70), Publisher: Sciendo
    Status:
    Published
    DOI:
    10.2478/hepo-2019-0001 – link to the publication

  4. Combined effects of methyldopa and baicalein or Scutellaria baicalensis roots extract on blood pressure, heart rate, and expression of inflammatory and vascular disease-related factors in spontaneously hypertensive pregnant rats.

    Authors:
    Szulc Michał, Kujawski Radosław, Mikołajczak Przemysław Ł., Bogacz Anna, Wolek Marlena, Górska Aleksandra, Czora-Poczwardowska Kamila, Ożarowski Marcin, Gryszczyńska Agnieszka, Baraniak Justyna, Kania-Dobrowolska Małgorzata, Adamczak Artur, Iwańczyk-Skalska Ewa, Jagodziński Paweł P., Czerny Bogusław, Kamiński Adam, Uzar Izabela, Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Pharmaceuticals (year: 2022, volume: 15(11), pages: 11689), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15111342 – link to the publication

  5. Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

    Authors:
    Ożarowski M, Mikołajczak PŁ, Kujawski R, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A
    Academic press:
    Evid Based Complement Alternat Med (year: 2018, volume: 7421489, pages: 46041), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/7421489 – link to the publication

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