Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The involvement of flavonoids on the development of pregnacy - induced hypertension in in vitro and in vivo studies

2017/25/B/NZ7/02741

Keywords:

flavonoids animal model pregnant markers antioxidant placenta heart aorta blood mRNA expression

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Włókien Naturalnych i Roślin Zielarskich

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Seremak-Mrozikiewicz 

Number of co-investigators in the project: 10

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 864 947 PLN

Project start date (Y-m-d): 2018-02-22

Project end date (Y-m-d): 2021-02-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do pośredniego pomiaru ciśnienia skurczowego i rozkurczowego oraz akcji serca u szczurów przytomnych wraz z akcesoriami z wykorzystaniem telemetrii (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Combined effects of methyldopa and baicalein or Scutellaria baicalensis roots extract on blood pressure, heart rate, and expression of inflammatory and vascular disease-related factors in spontaneously hypertensive pregnant rats.
    Authors:
    Szulc Michał, Kujawski Radosław, Mikołajczak Przemysław Ł., Bogacz Anna, Wolek Marlena, Górska Aleksandra, Czora-Poczwardowska Kamila, Ożarowski Marcin, Gryszczyńska Agnieszka, Baraniak Justyna, Kania-Dobrowolska Małgorzata, Adamczak Artur, Iwańczyk-Skalska Ewa, Jagodziński Paweł P., Czerny Bogusław, Kamiński Adam, Uzar Izabela, Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15(11), strony: 11689), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15111342 - link to the publication
  2. Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies
    Authors:
    Ożarowski M, Mikołajczak PŁ, Kujawski R, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A
    Academic press:
    Evid Based Complement Alternat Med (rok: 2018, tom: 7421489, strony: 45310), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/7421489 - link to the publication
  3. Plant phenolics and extracts in animal models of preeclampsia and clinical trials - review of perspectives for novel therapies
    Authors:
    Ożarowski Marcin, Karpiński Tomasz M., Szulc Michał, Wielgus Karolina, Kujawski Radosław, Wolski Hubert, Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14(3), strony: 269), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14030269 - link to the publication
  4. In vitro and in vivo activities of flavonoids - apigenin, baicalin, chrysin, scutellarin - in regulation of hypertension - a review for their possible effects in pregnancy-induced hypertension
    Authors:
    Ożarowski M, Kujawski R, Mikołajczak PŁ, Wielgus K, Klejewski A, Wolski H, Seremak-Mrozikiewicz A.
    Academic press:
    Herba Polonica (rok: 2019, tom: 65(1), strony: 55-70), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/hepo-2019-0001 - link to the publication
  5. Combined effects of methyldopa and flavonoids on the expression of selected factors related to inflammatory processes and vascular diseases in human placenta cells - an in vitro study
    Authors:
    Bogacz Anna, Mikołajczak Przemysław Ł., Wołek Marlena, Górska Aleksandra, Szulc Michał, Ożarowski Marcin, Kujawski Radosław, Czerny Bogusław, Wolski Hubert, Karpiński Tomasz M., Seremak-Mrozikiewicz Agnieszka
    Academic press:
    Molecules (rok: 2021, tom: 26(5), strony: 1259(1-20)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26051259 - link to the publication

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