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The role of DNMT2 methyltransferase in the regulation of genomic plasticity in cancer cells

2017/25/B/NZ2/01983

Keywords

Descriptors

  • NZ2_5: Cytogenetyka

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych; Instytut Biologii i Biotechnologii

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maciej Antoni Wnuk

Number of co-investigators in the project: 4

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 432 920 PLN
Project start date
2018-01-03
Project end date
2023-01-02
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Przepływowy cytometr obrazowy FlowSight. Cost: 498 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence

    Authors:
    Bloniarz D, Adamczyk-Grochala J, Lewinska A, Wnuk M.
    Academic press:
    Aging (year: 2021, volume: 13(12), pages: 15833-15874), Publisher: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203203 – link to the publication

  2. RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines.

    Authors:
    Betlej G, Ząbek T, Lewińska A, Błoniarz D, Rzeszutek I, Wnuk M.
    Academic press:
    Journal of Bone Oncology (year: 2022, volume: 36, pages: 100448), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbo.2022.100448 – link to the publication

  3. Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells

    Authors:
    Betlej G, Lewińska A, Adamczyk-Grochala J, Błoniarz D, Rzeszutek I, Wnuk M.
    Academic press:
    Toxicol In Vitro (year: 2022, volume: 80, pages: 105323), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2022.105323 – link to the publication

  4. c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells

    Authors:
    Lewinska A, Klukowska-Rötzler J, Deregowska A, Adamczyk-Grochala J, Wnuk M.
    Academic press:
    Redox Biology (year: 2019, volume: 24, pages: 101163), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2019.101163 – link to the publication

  5. Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells.

    Authors:
    Betlej G, Błoniarz D, Lewińska A, Wnuk M.
    Academic press:
    Chemico-Biological Interactions (year: 2023, volume: 369, pages: 110254), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2022.110254 – link to the publication

  6. Lapatinib- and fulvestrant-PAMAM dendrimer conjugates promote apoptosis in chemotherapy-induced senescent breast cancer cells with different receptor status

    Authors:
    Lewińska A, Wróbel K, Błoniarz D, Adamczyk-Grochala J, Wołowiec S, Wnuk M.
    Academic press:
    Biomaterials Advances (Formerly known as Materials Science and Engineering: C) (year: 2022, volume: 140, pages: 213047), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2022.213047 – link to the publication

  7. 5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells

    Authors:
    Filip K, Lewińska A, Adamczyk-Grochala J, Marino Gammazza A, Cappello F, Lauricella M, Wnuk M.
    Academic press:
    Cells (year: 2022, volume: 11(7), pages: 1213), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11071213 – link to the publication

  8. DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis

    Authors:
    Adamczyk-Grochala J, Bloniarz D, Zielinska K, Lewinska A, Wnuk M.
    Status:
    Accepted for publication

Articles in post-conference publications (5)

  1. The role of methyltransferase DNMT2 in the maintenance of telomere length and the regulation of genomic plasticity of cancer cells

    Authors:
    Adamczyk-Grochala J., Lewińska A., Maziarz K., Bednarska I., Noga M., Olszówka J., Bielak-Żmijewska A., Janiszewska D., Wnuk M.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 24), Publisher: IBB, Warsaw
    Date:
    conference 13-14.09.2018
    Status:
    Published

  2. The role of methyltransferase DNMT2 in the maintenance of telomere length in cancer cells

    Authors:
    Anna Lewinska, Jagoda Adamczyk-Grochala, Jakub Olszowka, Maciej Noga, Tomasz Zabek, Maciej Wnuk
    Conference:
    III Molecular Biology of Ageing Meeting (year: 2019, pages: 29), Publisher: Groningen Congres Bureau ERIBA
    Date:
    conference 2019-10-10-2019-10-12
    Status:
    Published

  3. The role of methyltransferase DNMT2 in the regulation of genomic plasticity of cancer cells

    Authors:
    Lewińska A., Adamczyk-Grochala J.
    Conference:
    EMBO EMBL Symposium: Principles of Chromosome Structure and Function (year: 2018, pages: 81), Publisher: EMBL, Heidelberg
    Date:
    conference 5-8.09.2018
    Status:
    Published

  4. The loss of DNMT2/TRDMT1 gene promotes the retrotransposon activity-mediated genome plasticity in cancer cells

    Authors:
    Wnuk M., Adamczyk-Grochala J., Maziarz K., Bednarska I., Noga M., Olszówka J., Lewinska A.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 49), Publisher: IBB, Warsaw
    Date:
    conference 13-14.09.2018
    Status:
    Published

  5. Relationship between the levels of DNMT2/TRDMT1, telomere length and TERRA expression in cancer cells

    Authors:
    Lewińska A., Adamczyk-Grochala J., Noga M., Olszówka J., Maziarz K., Bednarska I., Wnuk M.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 34), Publisher: IBB, Warsaw
    Date:
    conference 13-14.09.2018
    Status:
    Published

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