Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of DNMT2 methyltransferase in the regulation of genomic plasticity in cancer cells

2017/25/B/NZ2/01983

Keywords:

DNMT2 telomerase cancer genomic plasticity

Descriptors:

  • NZ2_5: Cell genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych, Instytut Biologii i Biotechnologii

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Wnuk 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 432 920 PLN

Project start date (Y-m-d): 2018-01-03

Project end date (Y-m-d): 2023-01-02

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Przepływowy cytometr obrazowy FlowSight (498 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (5)
  1. Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells.
    Authors:
    Betlej G, Błoniarz D, Lewińska A, Wnuk M.
    Academic press:
    Chemico-Biological Interactions (rok: 2023, tom: 369, strony: 110254), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cbi.2022.110254 - link to the publication
  2. The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence
    Authors:
    Bloniarz D, Adamczyk-Grochala J, Lewinska A, Wnuk M.
    Academic press:
    Aging (rok: 2021, tom: 13(12), strony: 15833-15874), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/aging.203203 - link to the publication
  3. Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells
    Authors:
    Tomasz Zabek, Tomasz Szmatola, Jagoda Adamczyk-Grochala, Anna Lewinska, Maciej Wnuk
    Academic press:
    Journal of Neuro-Oncology (rok: 2023, ), Wydawca: Springer (dostęp do artykułu będzie otwarty w ramach umowy PL z wydawnictwem Springer, jeśli artykuł zostanie przyjęty do druku)
    Status:
    Submitted
    DOI:
    Submission - link to the publication
  4. RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines.
    Authors:
    Betlej G, Ząbek T, Lewińska A, Błoniarz D, Rzeszutek I, Wnuk M.
    Academic press:
    Journal of Bone Oncology (rok: 2022, tom: 36, strony: 100448), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbo.2022.100448 - link to the publication
  5. c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells
    Authors:
    Lewinska A, Klukowska-Rötzler J, Deregowska A, Adamczyk-Grochala J, Wnuk M.
    Academic press:
    Redox Biology (rok: 2019, tom: 24, strony: 101163), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2019.101163 - link to the publication
  6. Lapatinib- and fulvestrant-PAMAM dendrimer conjugates promote apoptosis in chemotherapy-induced senescent breast cancer cells with different receptor status
    Authors:
    Lewińska A, Wróbel K, Błoniarz D, Adamczyk-Grochala J, Wołowiec S, Wnuk M.
    Academic press:
    Biomaterials Advances (Formerly known as Materials Science and Engineering: C) (rok: 2022, tom: 140, strony: 213047), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2022.213047 - link to the publication
  7. 5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells
    Authors:
    Filip K, Lewińska A, Adamczyk-Grochala J, Marino Gammazza A, Cappello F, Lauricella M, Wnuk M.
    Academic press:
    Cells (rok: 2022, tom: 11(7), strony: 1213), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11071213 - link to the publication
  8. Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells
    Authors:
    Betlej G, Lewińska A, Adamczyk-Grochala J, Błoniarz D, Rzeszutek I, Wnuk M.
    Academic press:
    Toxicol In Vitro (rok: 2022, tom: 80, strony: 105323), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2022.105323 - link to the publication
  9. DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis
    Authors:
    Adamczyk-Grochala J, Bloniarz D, Zielinska K, Lewinska A, Wnuk M.
    Academic press:
    Apoptosis (rok: 2022, ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s10495-022-01779-0 - link to the publication
  1. The role of methyltransferase DNMT2 in the regulation of genomic plasticity of cancer cells
    Authors:
    Lewińska A., Adamczyk-Grochala J.
    Conference:
    EMBO EMBL Symposium: Principles of Chromosome Structure and Function (rok: 2018, ), Wydawca: EMBL, Heidelberg
    Data:
    konferencja 5-8.09.2018
    Status:
    Published
  2. Relationship between the levels of DNMT2/TRDMT1, telomere length and TERRA expression in cancer cells
    Authors:
    Lewińska A., Adamczyk-Grochala J., Noga M., Olszówka J., Maziarz K., Bednarska I., Wnuk M.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (rok: 2018, ), Wydawca: IBB, Warsaw
    Data:
    konferencja 13-14.09.2018
    Status:
    Published
  3. The loss of DNMT2/TRDMT1 gene promotes the retrotransposon activity-mediated genome plasticity in cancer cells
    Authors:
    Wnuk M., Adamczyk-Grochala J., Maziarz K., Bednarska I., Noga M., Olszówka J., Lewinska A.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (rok: 2018, ), Wydawca: IBB, Warsaw
    Data:
    konferencja 13-14.09.2018
    Status:
    Published
  4. The role of methyltransferase DNMT2 in the maintenance of telomere length and the regulation of genomic plasticity of cancer cells
    Authors:
    Adamczyk-Grochala J., Lewińska A., Maziarz K., Bednarska I., Noga M., Olszówka J., Bielak-Żmijewska A., Janiszewska D., Wnuk M.
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (rok: 2018, ), Wydawca: IBB, Warsaw
    Data:
    konferencja 13-14.09.2018
    Status:
    Published
  5. The role of methyltransferase DNMT2 in the maintenance of telomere length in cancer cells
    Authors:
    Anna Lewinska, Jagoda Adamczyk-Grochala, Jakub Olszowka, Maciej Noga, Tomasz Zabek, Maciej Wnuk
    Conference:
    III Molecular Biology of Ageing Meeting (rok: 2019, ), Wydawca: Groningen Congres Bureau ERIBA
    Data:
    konferencja 2019-10-10-2019-10-12
    Status:
    Published

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