Projects funded by the NCN
The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional characterization.
2017/25/B/NZ7/01290
Keywords:
tuberculosis RNA metabolism drug targets polyadenylation DNA repair
Descriptors:
- NZ7_14:
- NZ7_16:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Biologii Medycznej PAN
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 13 - announced on 2017-03-15
Amount awarded: 1 394 169 PLN
Project start date (Y-m-d): 2018-02-06
Project end date (Y-m-d): 2022-02-05
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Depletion of tRNA CCA-adding enzyme in Mycobacterium tuberculosis leads to polyadenylation of transcripts and precursor tRNAsAuthors:Błaszczyk E, Płociński P, Lechowicz E, Brzostek A, Dziadek B, Korycka-Machała M, Słomka M, Dziadek J.Academic press:Scientific Reports (rok: 2023, tom: 13, strony: 47944-6), Wydawca: Springer NatureStatus:PublishedDOI:10.1038/s41598-023-47944-6 - link to the publication
- Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase CAuthors:Brissett NC, Zabrady K, Płociński P, Bianchi J, Korycka-Machała M, Brzostek A, Dziadek J, Doherty AJ.Academic press:NATURE COMMUNICATIONS (rok: 2020, tom: 11, strony: Article Number 4196), Wydawca: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLANDStatus:PublishedDOI:10.1038/s41467-020-180 - link to the publication