Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Diffusion in a crowded environment of living cells: Effects of properties of macromolecules and cell metabolism

2017/25/B/ST3/02456

Keywords:

diffusion macromolecules metabolites living systems crowded environments metabolism

Descriptors:

  • NZ1_3: Biophysics
  • ST3_4: Electronic properties of materials, surfaces, interfaces, nanostructures, etc.

Panel:

ST3 - Condensed matter physics: structure, electronic properties, fluids, nanosciences, biological physics

Host institution :

Instytut Chemii Fizycznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Svyatoslav Kondrat 

Number of co-investigators in the project: 3

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 852 680 PLN

Project start date (Y-m-d): 2018-02-14

Project end date (Y-m-d): 2023-02-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. maly kluster komputerowy (60 000 PLN)
  2. QNAP file server (19 985 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Book publications / chapters in book publications (1)
  1. A minimal coarse-grained model for Immunoglobulin G (IgG): Diffusion and binding under crowding
    Authors:
    Edyta Slyk, Tomasz Skóra, and Svyatoslav Kondrat
    Academic press:
    Journal of Physical Chemistry B (rok: 2023, tom: 127, strony: 7442-7448), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.3c02383 - link to the publication
  2. Can enzyme proximity accelerate cascade reactions?
    Authors:
    Andrij Kuzmak, Sheiliza Carmali, Eric von Lieres, Alan J Russell, Svyatoslav Kondrat
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 455), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-37034-3 - link to the publication
  3. Crowding-regulated binding of divalent biomolecules
    Authors:
    Tomasz Skóra, Mathijs Janssen, Andreas Carlson, and Svyatoslav Kondrat
    Academic press:
    Physical Review Letters (rok: 2023, tom: 130, strony: 258401), Wydawca: American Physical Society
    Status:
    Published
    DOI:
    10.1103/PhysRevLett.130.258401 - link to the publication
  4. Macromolecular Crowding: How Shape and Interactions Affect Diffusion
    Authors:
    Tomasz Skóra, Farzaneh Vaghefikia, Jörg Fitter, Svyatoslav Kondrat
    Academic press:
    The Journal of Physical Chemistry B (rok: 2020, tom: 124, strony: 7537-7543), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c04846 - link to the publication
  5. Size Sensitivity of Metabolite Diffusion in Macromolecular Crowds
    Authors:
    Edyta Słyk, Dariusz Gołowicz, Tomasz Skóra, Krzysztof Kazimierczuk, and Svyatoslav Kondrat
    Academic press:
    Nano Letters (rok: 2024, tom: na, strony: na), Wydawca: ACS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. Brownian dynamics assessment of enhanced diffusion exhibited by 'fluctuating-dumbbell enzymes'
    Authors:
    Svyatoslav Kondrat and Mihail N. Popescu
    Academic press:
    Phys. Chem. Chem. Phys. (rok: 2019, tom: 21, strony: 18811-18815), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9CP02842K - link to the publication
  7. Conformation-changing enzymes and macromolecular crowding
    Authors:
    Tomasz Skóra, Mihail N. Popescu, and Svyatoslav Kondrat
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2021, tom: 23, strony: 9065-9069), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    0.1039/D0CP06631A - link to the publication
  8. Enzyme co-localisation: Mechanisms and benefits
    Authors:
    Svyatoslav Kondrat, Ulrich Krauss, Eric von Lieres
    Academic press:
    Current research in chemical biology (rok: 2022, tom: 2, strony: 100031), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.crchbi.2022.100031 - link to the publication
  9. How macromolecules softness affects diffusion under crowding
    Authors:
    Edyta Słyk, Tomasz Skóra, Svyatoslav Kondrat
    Academic press:
    Soft Matter (rok: 2022, tom: 18, strony: 5366-5370), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2SM00357K - link to the publication
  1. Mechanisms and Effects of Substrate Channelling in Enzymatic Cascades
    Authors:
    Svyatoslav Kondrat, Eric von Lieres
    Book:
    Multienzymatic Assemblies (rok: 2021, tom: 3, strony: 27-50), Wydawca: Springer US
    Status:
    Published

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