Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Design and validation of a novel form of therapy in intestinal inflammation and colitis associated colorectal cancer based on gold (III) complexes

2017/25/B/NZ5/02848

Keywords:

inflammatory bowel disease colorectal cancer inflammation gold derivatives fatty acids

Descriptors:

  • NZ7_14:
  • NZ4_12:
  • NZ5_9:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jakub Jerzy Fichna 

Number of co-investigators in the project: 13

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 443 848 PLN

Project start date (Y-m-d): 2018-02-13

Project end date (Y-m-d): 2023-02-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (4)
  • Book publications / chapters in book publications (1)
  1. A new gold(III) complex TGS 703 shows potent an-ti-inflammatory activity in colitis via the enzymatic and non-enzymatic antioxidant system – an in vitro, in silico, and in vivo study
    Authors:
    Jakub Włodarczyk, Julia Krajewska, Łukasz Szeleszczuk, Patrycja Szałwińska, Agata Gurba, Szymon Lipiec, Przemysław Taciak, Remigiusz Szczepaniak, Izabela Mlynarczuk-Bialy, Jakub Fichna
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 7025), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  2. Organometallic Compounds and Metal Complexes in Current and Future Treatments of Inflammatory Bowel Disease and Colorectal Cancer—a Critical Review
    Authors:
    Adrian Szczepaniak i Jakub Fichna
    Academic press:
    Biomolecules (rok: 2019, tom: 9, strony: 45680), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom9090398 - link to the publication
  3. Gold (III) Derivatives in Colon Cancer Treatment
    Authors:
    Agata Gurba, Przemysław Taciak, Mariusz Sacharczuk, Izabela Młynarczuk-Biały, Magdalena Bujalska-Zadrożny, Jakub Fichna
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45708), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020724 - link to the publication
  4. New Class of Anti‐Inflammatory Therapeutics Based on Gold (III) Complexes in Intestinal Inflammation - Proof of Concept Based on In Vitro and In Vivo Studies.
    Authors:
    Julia B. Krajewska, Jakub Włodarczyk, Damian Jacenik, Radzisław Kordek, Przemysław Taciak, Remigiusz Szczepaniak, Jakub Fichna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45703), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063121 - link to the publication
  5. New gold (III) cyanide complex TGS 121 induces ER stress, proteasome inhibition and death of Ras-hyperactivated cells
    Authors:
    Szymon Lipiec, Agata Gurba, Izabela M. Agnieszczak, Andrzej Antoni Szczepankiewicz, Przemysław Szymanski, Przemysław Taciak, Remigiusz Szczepaniak, Łukasz Szeleszczuk, Hanna Nieznanska, Jakub Włodarczyk, Jakub Fichna, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
    Academic press:
    Toxicology in Vitro (rok: 2023, tom: 88, strony: 105556), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2023.105556 - link to the publication
  6. Innovative gold complexes with CN group as anticancer agents – possible mechanisms of action
    Authors:
    Szymon Lipiec, Przemysław Szymański, Agata Gurba, Łukasz Szeleszczuk, Przemysław Taciak, Jakub Fichna, Izabela Młynarczuk-Biały
    Academic press:
    Review and Research on Cancer Treatment (rok: 2021, tom: 7, strony: 45761), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Status:
    Published
    DOI:
    link to the publication
  7. New Class of Anti‐Inflammatory Therapeutics Based on Gold (III) Complexes in Intestinal Inflammation - Proof of Concept Based on In Vitro and In Vivo Studies.
    Authors:
    Julia B. Krajewska, Jakub Włodarczyk, Damian Jacenik, Radzisław Kordek, Przemysław Taciak, Remigiusz Szczepaniak, Jakub Fichna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45703), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063121 - link to the publication
  8. Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain
    Authors:
    Anna Zielińska, Maciej Sałaga, Marcin Włodarczyk, Jakub Fichna
    Academic press:
    International Journal of Colorectal Disease (rok: 2019, tom: 34 (6), strony: 217-227 (2019)), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00384-018-3218-0 - link to the publication
  9. Gold (III) Derivatives in Colon Cancer Treatment
    Authors:
    Agata Gurba, Przemysław Taciak, Mariusz Sacharczuk, Izabela Młynarczuk-Biały, Magdalena Bujalska-Zadrożny, Jakub Fichna
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45708), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020724 - link to the publication
  10. New gold (III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitisinduced colorectal cancer – an in vitro and in vivo study
    Authors:
    Jakub Włodarczyk, Julia Krajewska, Marcin Talar, Łukasz Szeleszczuk, Agata Gurba, Szymon Lipiec, Przemysław Taciak, Remigiusz Szczepaniak, Izabela Młynarczuk-Biały, Jakub Fichna
    Status:
    Accepted for publication
  1. DEVELOPMENT AND VALIDATION OF AN IN VITRO MODEL OF COLITIS FOR THE SCREENING OF POTENTIAL THERAPEUTIC AGENTS IN INFLAMMATORY BOWEL DISEASE (IBD)
    Authors:
    Julia Krajewska, Jakub Włodarczyk, Karolina Niewinna, Przemysław Taciak, Remigiusz Szczepaniak, Jakub Fichna
    Conference:
    The 44 th FEBS CONGRESS (rok: 2019, ), Wydawca: The FEBS Congress
    Data:
    konferencja 43652
    Status:
    Published
  2. Challenges In Design Of Novel Treatment Options In Inflammatory Bowel Diseases Employing Gold And Silver
    Authors:
    Jakub Fichna, Julia Krajewska, Jakub Włodarczyk, Damian Jacenik, Marta Zielińska
    Conference:
    11th Joint Meeting on Medicinal Chemistry 2019 (rok: 2019, ), Wydawca: The Faculty of Pharmacy, Charles University
    Data:
    konferencja 2019-06-27-30
    Status:
    Published
  3. New class of anti-inflammatory therapeutics based on gold (III) complexes in intestinal inflammation – proof of concept based on in vitro and in vivo studies
    Authors:
    Julia Krajewska, Jakub Włodarczyk, Przemysław Taciak, Remigiusz Szczepaniak, Jakub Fichna
    Conference:
    Digestive Disease Week 2019 (rok: 2019, ), Wydawca: AGA
    Data:
    konferencja 2019-05-18-21
    Status:
    Published
  4. Mouse models of inflammatory bowel diseases and colitis-associated colorectal cancer –successes and failures
    Authors:
    Jakub Ficha
    Conference:
    XXI Zjazd Polskiego Towarzystwa PATOLOGÓW (rok: 2019, ), Wydawca: Polskie Towarzystwo Patalogów
    Data:
    konferencja 2019-09-26-28
    Status:
    Published
  1. Silver nanoparticles for drug delivery in inflammatory bowel disease
    Authors:
    Aleksandra Tarasiuk, Jakub Fichna
    Book:
    Status:
    Accepted for publication

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