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Rhinoviral infections of human vascular endothelium in the development of inflammation and airway remodeling in bronchial asthma

2017/25/B/NZ5/01575

Keywords

Descriptors

  • NZ5_1: Etiologia chorób człowieka
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, Międzywydziałowa Katedra Immunologii Klinicznej i Mikrobiologii

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maciej Zygmunt Chałubiński

Number of co-investigators in the project: 5

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 476 400 PLN
Project start date
2018-01-19
Project end date
2022-01-18
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny separator komórkowy AutoMACS Pro Separator. Cost: 250 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Human rhinovirus 16 induces antiviral and inflammatory response in the human vascular endothelium

    Authors:
    Chałubiński Maciej, Szulc Aleksandra, Pawełczyk Małgorzata, Gajewski Adrian, Gawrysiak Mateusz, Likońska Aleksandra, Kowalski Marek Leszek
    Academic press:
    Acta Pathologica, Microbiologica, et Immunologica Scandinavica (year: 2021, volume: 129(3), pages: 143-151), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/apm.13103 – link to the publication

  2. Human rhinovirus HRV16 impairs barrier functions and regeneration of human lung vascular endothelium

    Authors:
    Gawrysiak M, Gajewski A, Szewczyk R, Likońska A, Michlewska S, Chmiela M, Kowalski ML, Chałubiński M.
    Academic press:
    Allergy (year: 2020, volume: 0, pages: 46026), Publisher: Wiley and Sons, Ltd
    Status:
    Published
    DOI:
    10.1111/all.14671 – link to the publication

  3. IL-33 augments the effect of rhinovirus HRV16 on inflammatory activity of human lung vascular endothelium-possible implications for rhinoviral asthma exacerbations

    Authors:
    Gajewski A, Gawrysiak M, Szewczyk R, Gulbas I, Likońska A, Michlewska S, Kowalski ML, Chałubiński M
    Academic press:
    Allergy (year: 2021, volume: Jul;76(7), pages: 2282-2285), Publisher: Eauropean Academy of Allergy and Clinical Immunology
    Status:
    Published
    DOI:
    10.1111/all.14806 – link to the publication

  4. IL-33 prevents the enhancement of AP-N, DPP4, and ACE2 expression induced by rhinovirus HRV16 in the human lung endothelium—potential implications for coronaviral airway infections

    Authors:
    Gulbas I, Gajewski A, Gawrysiak M, Szewczyk R, Likońska A, Michlewska S, Kowalski ML, Chałubiński M.
    Academic press:
    Allergy (year: 2022, volume: 77(5), pages: 1610-1613), Publisher: Eauropean Academy of Allergy and Clinical Immunology
    Status:
    Published
    DOI:
    10.1111/all.15251 – link to the publication

Articles in post-conference publications (31)

  1. Human rhinovirus causes increase in angiogenetic activity of lung endothelial cells – potential involvement in enhanced vasculature in asthmatics

    Authors:
    Aleksandra Likonska, Adrian Gajewski, Mateusz Gawrysiak, Izabela Gulbas, Robert Szewczyk, Kinga Klimczak, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    European Respiratory Society International Congress (year: 2021, pages: 1), Publisher: ERS
    Date:
    conference 06.09.-09.09.
    Status:
    Published

  2. Analysis of transmission rhinovirus HRV-16 infection from airway epithelium to vascular pulmonary endothelium in an in vitro model

    Authors:
    Robert Szewczyk, Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likonska, Izabela Gulbas, Magdalena Chmiela, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    19th EAACI Immunology Winter School Basic Immunology Research in Allergy and Clinical Immunology (year: 2021, pages: 1), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 22-24.01.
    Status:
    Published

  3. IL-33 may augment the effect of rhinovirus HRV16 on the inflammatory activity of human lung vascular endothelium – possible implication for asthma exacerbations

    Authors:
    Adrian Gajewski, Mateusz Gawrysiak, Robert Szewczyk, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Respiratory Society International Congress (year: 2021, pages: 1), Publisher: ERS
    Date:
    conference 06.09.-09.09.
    Status:
    Published

  4. The Effect Of HRV16 On T2-Type Cytokine Profile Of Human Pulmonary Vascular Endothelium – Potential Intracellular Mechanisms

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Robert Szewczyk, Izabela Gulbas, Aleksandra Likońska, Sylwia Michlewska, Magdalena Chmiela, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    19th EAACI Immunology Winter School Basic Immunology Research in Allergy and Clinical Immunology (year: 2021, pages: 29), Publisher: European Academy of Allegy and Clinical Immunology
    Date:
    conference 22-24.01.
    Status:
    Published

  5. Human rhinovirus HRV16 enhances angiogenic activity of the lung vascular endothelium – potential implications for enhanced airway vasculature in asthma

    Authors:
    Aleksandra Likońska, Adrian Gajewski, Mateusz Gawrysiak, Izabela Gulbas, Robert Szewczyk, Kinga Klimczak, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Academy of Allergy and Clinical Immunology Hybrid Congress (EAACI) (year: 2021, pages: 484), Publisher: Eauropean Academy of Allergy and Clinical Immunology
    Date:
    conference 10.07-12.07
    Status:
    Published

  6. The effect of human rhinovirus HRV-16 on the barrier properties and regeneration of human pulmonary endothelium

    Authors:
    Gawrysiak Mateusz, Gajewski Aadrian, Likonska Aleksandra, Szewczyk Robert, Chmiela Magdalena, Kowalski Marek Leszek, Chalubinski Maciej
    Conference:
    Eauropean Academy of Allergy and Clinical Immunology Annual Congress 2020 (year: 2020, pages: 27), Publisher: Wiley
    Date:
    conference 6-8 June
    Status:
    Published

  7. Interferon-dependant and immune cell-based mechanisms of antiviral resistance of the human lung vascular endothelium infected with rhinovirus HRV16

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Robert Szewczyk, Mateusz Kobierecki, Michał Szymański, Izabela Gulbas, Aleksandra Likońska, Sylwia Michlewska, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Respiratory Society International Congress (year: 2021, pages: 1), Publisher: ERS
    Date:
    conference 06.09.-09.09.
    Status:
    Published

  8. The effect of human rhinovirus HRV-16 on angiogenesis and remodeling in 3D cultures of human pulmonary endothelium

    Authors:
    Likonska Aleksandra Joanna, Gajewski Adrian, Gawrysiak, Mateusz, Klimczak Kinga, Kowalski Marek L., Chalubinski Maciej
    Conference:
    Eauropean Academy of Allergy and Clinical Immunology Annual Congress 2020 (year: 2020, pages: 328), Publisher: Wiley
    Date:
    conference 6-8 June
    Status:
    Published

  9. Airway cells infected by HRV-16 may pass infection to pulmonary microvascular endothelium in vitro- possible mechanism in asthma exacerbations

    Authors:
    Robert Szewczyk, Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likońska, Izabela Gulbas, Magdalena Chmiela, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Alergologicznego (year: 2021, pages: 9), Publisher: PTA
    Date:
    conference 29.09.-02.10.
    Status:
    Published

  10. The modulatory effect of IL- 33, IL- 25 and IL- 5 on human rhinovirus- induced anti- viral, inflammatory and Th2- type cytokine response by human pulmonary endothelium

    Authors:
    Gajewski Adrian, Gawrysiak Mateusz, Likonska Aleksandra, Szewczyk Robert, Chmiela Magdalena, Kowalski Marek L., Chalubinski Maciej
    Conference:
    European Academy of Allergy and Clinical Immunology Congress (year: 2020, pages: 28), Publisher: Wiley
    Date:
    conference 6-8 June
    Status:
    Published

  11. Human rhinovirus HRV16 may increase angiogenetic activity of lung vascular endothelial cells – potential contribution to airway remodelling in asthma

    Authors:
    Aleksandra Likońska, Adrian Gajewski, Mateusz Gawrysiak, Izabela Gulbas, Robert Szewczyk, Kinga Klimczak, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Alergologicznego (year: 2021, pages: 1), Publisher: PTA
    Date:
    conference 29.09.-02.10.
    Status:
    Published

  12. IL-33 may augment the effect of rhinovirus HRV16 on the inflammatory activity of human lung vascular endothelium – possible implication for rhinoviral asthma exacerbations

    Authors:
    Adrian Gajewski, Mateusz Gawrysiak, Robert Szewczyk, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Alergologicznego (year: 2021, pages: 4), Publisher: PTA
    Date:
    conference 29.09.-02.10.
    Status:
    Published

  13. WPŁYW RINOWIRUSA HRV16 NA ANGIOGENNE WŁAŚCIWOŚCI LUDZKICH KOMÓREK ŚRÓDBŁONKA NACZYŃ PŁUCNYCH W HODOWLI 3D I 2D

    Authors:
    Aleksandra Likońska, Adrian Gajewski, Mateusz Gawrysiak, Kinga Klimczak, Robert Szewczyk, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    I Interdyscyplinarna Konferencja Doktorantów Uniwersytetu Medycznego w Łodzi (year: 2020, pages: 21), Publisher: Uniwersytet Medyczny w Łodzi
    Date:
    conference 7 listopada
    Status:
    Published

  14. The Effect Of Epithelium-Derived Innate Cytokines On The Expression Of Coronavirus 229E (AP-N) And Rhinovirus 16 (ICAM-1) Entry Receptors And Inflammatory Cytokines In Human Pulmonary Vascular Endothelium

    Authors:
    Izabela Gulbas, Mateusz Gawrysiak, Adrian Gajewski, Robert Szewczyk, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    19th EAACI Immunology Winter School Basic Immunology Research in Allergy and Clinical Immunology (year: 2021, pages: 40), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 22-24.01.
    Status:
    Published

  15. WPŁYW RINOWIRUSA HRV16 NA REGENERACJĘ ŚRÓDBŁONKA NACZYNIOWEGO I SYNTEZĘ CYTOKIN TYPU T2 – POTENCJALNE ZNACZENIE W IMMUNOPATOLOGII ZAOSTRZEŃ ASTMY OSKRZELOWEJ

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likońska, Robert Szewczyk, Sylwia Michlewska, Magdalena Chmiela, Marek Kowalski, Maciej Chałubiński
    Conference:
    I Interdyscyplinarna Konferencja Doktorantów Uniwersytetu Medycznego w Łodzi (year: 2020, pages: 17), Publisher: Uniwersytet medyczny w Łodzi
    Date:
    conference 7 listopada
    Status:
    Published

  16. Interferon-dependant mechanisms of antiviral resistance of the human lung vascular endothelium infected with rhinovirus HRV16 – relevance in asthma exacerbations

    Authors:
    Mateusz Gawrysiak, Michał Szymański, Mateusz Kobierecki, Adrian Gajewski, Robert Szewczyk, Izabela Gulbas, Aleksandra Likońska, Sylwia Michlewska, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XIV Międzynarodowy Kongres Polskiego Towarzystwa Alergologicznego (year: 2021, pages: 7), Publisher: PTA
    Date:
    conference 29.09.-02.10.
    Status:
    Published

  17. Mechanizmy oporności przeciwwirusowej śródbłonka naczyniowego płuc zakażonego HRV16 - znaczenie w zaostrzeniach astmy

    Authors:
    Mateusz Gawrysiak, Mateusz Kobierecki, Michał Szymański, Adrian Gajewski, Robert Szewczyk, Izabela Gulbas, Aleksandra Likońska, Sylwia Michlewska, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    IV Sesja Młodych Mikrobiologów Środowiska Łódzkiego (year: 2021, pages: 23), Publisher: Politechnika Łódzka
    Date:
    conference 23.06.
    Status:
    Published

  18. IL-33 may augment the effect of rhinovirus HRV16 on the inflammatory activity of human lung vascular endothelium – possible implication for rhinoviral asthma exacerbations

    Authors:
    Adrian Gajewski, Mateusz Gawrysiak, Robert Szewczyk, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Academy of Allergy and Clinical Immunology Hybrid Congress (EAACI) (year: 2021, pages: 729), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 10.07-12.07
    Status:
    Published

  19. The effect of human rhinovirus on the inflammatory response of human vascular endothelium

    Authors:
    Likońska Aleksandra, Gawrysiak Mateusz, Chałubiński Maciej, Kowalski Marek L.
    Conference:
    56th Polish and 14th International Juvenes Pro Medicina Conference (year: 2019, pages: 25), Publisher: Uniwersytet Medyczny w Łodzi
    Date:
    conference 24 maj
    Status:
    Published

  20. The Effect of Human Rhinovirus (HRV-16) on Angiogenic Properties of Human Pulmonary Vascular Endothelium

    Authors:
    Kinga Klimczak, Maciej Chałubiński, Aleksandra Likońska, Marek L. Kowalski
    Conference:
    Juvenes Pro Medicina (year: 2020, pages: 35), Publisher: Uniwersytet Medyczny w Łodzi
    Date:
    conference 15.05-16.05.
    Status:
    Published

  21. The modulatory effect of IL-33 on HRV-16 infection and inflammatory cytokine expression in the pulmonary endothelium in the immunopathology of asthma

    Authors:
    Adrian Lukasz Gajewski, Mateusz Gawrysiak, Aleksandra Likonska, Magdalena Chmiela, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    18th Immunology Winter School on Basic Immunology Research in Allergy and Clinical Immunology (year: 2020, pages: 31-32), Publisher: Eauropean Academy of Allergy and Clinical Immunology
    Date:
    conference 23-26 January
    Status:
    Published

  22. The effecto of human rhinovirus HRV-16 on angiogenesis in 3D cultures

    Authors:
    Aleksandra Likonska, Adrian Gajewski, Mateusz Gawrysiak, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    18th Immunology Winter School on Basic Immunology Research in Allergy and Clinical Immunology (year: 2020, pages: 77-78), Publisher: Eauropean Academy of Allergy and Clinical Immunology
    Date:
    conference 23-26 January
    Status:
    Published

  23. Human rhinovirus HRV16 induces antiviral responses and inhibits regeneration of human lung microvascular endothelium

    Authors:
    Maciej Chalubinski, Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Szulc, Malgorzata Pawelczyk, Aleksandra Likonska, Robert Szewczyk, Magdalena Chmiela, Marek Kowalski
    Conference:
    AAAAI Annual Meeting (year: 2020, pages: 554), Publisher: Elsevier
    Date:
    conference 12.03.-16.03.
    Status:
    Published

  24. The Effect Of Rhinovirus HRV-16 On Barrier Properties And Regeneration Of Vascular Endothelium In The Pathogenesis Of Asthma

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likonska, Robert Szewczyk, Magdalena Chmiela, Marek L. Kowalski, Maciej Chalubinski
    Conference:
    18th Immunology Winter School on Basic Immunology Research in Allergy and Clinical Immunology (year: 2020, pages: 62), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 23-26 January
    Status:
    Published

  25. Wpływ rinowirusa HRV-16 na właściwości barierowe śródbłonka naczyniowego w patogenezie astmy oskrzelowej

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likońska, Magdalena Chmiela, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XVIII Konferencja Naukowo-szkoleniowa ALERGIA ASTMA IMMUNOLOGIA KLINICZNA (year: 2019, pages: 108), Publisher: Mediton
    Date:
    conference 13-15.06.2019
    Status:
    Published

  26. Ludzki rinowirus HRV-16 może zwiększać aktywność proangiogenną ludzkich komórek mikrowaskularnych naczyń płucnych – ocena potencjalnego wpływu na remodeling oskrzeli w astmie

    Authors:
    Aleksandra Likońska, Adrian Gajewski, Mateusz Gawrysiak, Izabela Gulbas, Robert Szewczyk, Kinga Klimczak, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    IV Sesja Młodych Mikrobiologów Środowiska Łódzkiego (year: 2021, pages: 26), Publisher: Uniwersytet Łódzki
    Date:
    conference 23.06.
    Status:
    Published

  27. Wpływ ludzkiego rinowirusa na odpowiedź zapalną śródbłonka naczyniowego

    Authors:
    Aleksandra Likońska, Mateusz Gawrysiak, Aleksandra Szulc, Małgorzata Pawełczyk, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    XVIII Konferencja Naukowo-szkoleniowa ALERGIA ASTMA IMMUNOLOGIA KLINICZNA (year: 2019, pages: 108), Publisher: Mediton
    Date:
    conference 13-15.06.2019
    Status:
    Published

  28. The effect of rhinovirus HRV16 on barrier properties and regeneration of lung vascular endothelium in the immunopathology of asthma

    Authors:
    Mateusz Gawrysiak, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    16th International and 58th Polish Conference JUVENES PRO MEDICINA (year: 2020, pages: 47), Publisher: Uniwersytet Medyczny w Łodzi
    Date:
    conference 15-16 maja
    Status:
    Published

  29. Primary infection of vascular endothelium with human rhinovirus HRV16 may induce and sustain cellular anti- viral resistance

    Authors:
    Chalubinski M ; Szulc A ; Pawelczyk M ; Kowalski ML
    Conference:
    European Academy of Allergy and Clinical Immunology Congress (year: 2019, pages: 351), Publisher: EAACI and John Wiley and Sons A/S
    Date:
    conference 1-5.06
    Status:
    Published

  30. HRV16 infection may spread from infected airway epithelium and lung vascular endothelium to uninfected endothelium – possible consequences for asthma exacerbations

    Authors:
    Robert Szewczyk, Mateusz Gawrysiak, Adrian Gajewski, Aleksandra Likońska, Izabela Gulbas, Magdalena Chmiela, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Academy of Allergy and Clinical Immunology Hybrid Congress (EAACI) (year: 2021, pages: 806), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 10.07-12.07
    Status:
    Published

  31. Interferon-dependant and immune cell based mechanisms of antiviral resistance of the human lung vascular endothelium infected with rhinovirus HRV16 – relevance in asthma exacerbations

    Authors:
    Mateusz Gawrysiak, Adrian Gajewski, Robert Szewczyk, Michał Szymański, Mateusz Kobierecki, Izabela Gulbas, Aleksandra Likońska, Sylwia Michlewska, Marek L. Kowalski, Maciej Chałubiński
    Conference:
    European Academy of Allergy and Clinical Immunology Hybrid Congress (EAACI) (year: 2021, pages: 411), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 10.07-12.07.
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski