Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Phosphorus dendrimers as carriers of photosensitizers - in vivo studies

2017/25/B/NZ7/01304

Keywords:

nanomedicine dendrimer photodynamic therapy cancer

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Klajnert-Maculewicz 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 263 200 PLN

Project start date (Y-m-d): 2018-10-01

Project end date (Y-m-d): 2023-09-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Lampa Q.Light (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Nanocarriers in photodynamic therapy - in vitro and in vivo studies
    Authors:
    Krzysztof Sztandera, Michał Gorzkiewicz, Barbara Klajnert-Maculewicz
    Academic press:
    WIREs: Nanomedicine and Nanobiotechnology (rok: 2019, tom: e1509, strony: 45315), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/wnan.1599 - link to the publication
  2. Noncovalent interactions with PAMAM and PPI dendrimers promote the cellular uptake and photodynamic activity of Rose Bengal: The role of dendrimer structure
    Authors:
    K. Sztandera, M. Gorzkiewicz, A. S. Dias Martins, L. Pallante, E. A. Zicci, M. Miceli, M. Batal, C. Pinto Reis, M. A. Deriu, B. Klajnert-Maculewicz
    Academic press:
    Journal of Medicinal Chemistry (rok: 2021, tom: 64, strony: 15758-15771), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c01080 - link to the publication
  3. pH-stable polymersome as nanocarrier for post-loaded Rose Bengal in photodynamic therapy
    Authors:
    K. Sztandera, M. Gorzkiewicz, X. Wang, S. Boye, D. Appelhans, B. Klajnert-Maculewicz
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2022, tom: 217, strony: 112662-112671), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2022.112662 - link to the publication
  4. In search of a phosphorus dendrimer-based carrier of rose bengal: Tyramine linker limits fluorescent and phototoxic properties of a photosensitizer
    Authors:
    K. Sztandera, M. Marcinkowska, M. Gorzkiewicz, A. Janaszewska, R. Laurent, M. Zabłocka, S. Mignani, J. P. M. Majoral, B. Klajnert-Maculewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 4456-4576), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124456 - link to the publication
  5. Triazine-carbosilane dendrimersomes enhance cellular uptake and phototoxic activity of Rose Bengal in basal cell skin carcinoma cells
    Authors:
    K. Sztandera, M. Gorzkiewicz, M. Bątal, V. Arkhipova, N. Knauer, J. Sanchez-Nieves, F.J. de la Mata, R. Gomez, E. Apartsin, B. Klajnert-Maculewicz
    Academic press:
    International Journal of Nanomedicine (rok: 2022, tom: 17, strony: 11-39-1154), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S352349 - link to the publication
  6. Cellular uptake of rose bengal is mediated by OATP1B1/1B3 transporters
    Authors:
    K. Sztandera, M. Gorzkiewicz, E.A. Zizzi, N. Dybczak, L. Poltorak, M. A. Deriu, B. Klajnert-Maculewicz
    Academic press:
    Bioelectrochemistry (rok: 2023, tom: 152, strony: 108449), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2023.108449 - link to the publication
  1. Phosphorus dendrimers as Rose Bengal carriers in photodynamic therapy
    Authors:
    Krzysztof Sztandera, Magdalena Milczarek, Marta Majkowska, Joanna Wietrzyk, Barbara Klajnert-Maculewicz
    Conference:
    11th International Dendrimer Symposium (rok: 2019, ), Wydawca: University of Madeira
    Data:
    konferencja 14-18 lipca 2019 r.
    Status:
    Published

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