Examining phenotype of mice carrying a novel dominant-negative, spontaneous mutation of spectrin alpha II encoding gene (Spna2)
2017/25/B/NZ3/03012
Keywords
Descriptors
- NZ3_6: Neurobiologia komórkowa
- NZ3_7: Przekaźnictwo sygnału
- NZ6_1: Odporność swoista i nieswoista
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 13 – announced on 2017-03-15
- Amount awarded
- 784 080 PLN
- Project start date
- 2018-02-16
- Project end date
- 2022-02-15
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Czytnik ELISPOT. Cost: 90 000 PLN
- Indywidualnie wentylowane klatki dla myszy z butelkami (40 sztuk) (40 pcs). Cost: 25 000 PLN
- Kompaktowy analizator komórkowy. Cost: 68 000 PLN
- Mini-spektrofotometr UV/Vis. Cost: 45 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
An alpha II spectrin mutant peptide with unstable scaffold structure and increased sensitivity to calpain cleavage
- Authors:
- Joanna Skrzymowska, Michał Zalas, Krzysztof Goszczyński, Arkadiusz Miazek
- Academic press:
- Biochemical and Biophysical Research Communications (year: 2021, volume: 581, pages: 68-73), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbrc.2021.10.021 – link to the publication
-
Age-dependent ataxia and neurodegeneration caused by an αΙΙ spectrin mutation with impaired regulation of its calpain sensitivity
- Authors:
- Arkadiusz Miazek, Michał Zalas, Joanna Skrzymowska, Bryan A. Bogin, Krzysztof Grzymajło, Tomasz Goszczynski, Zachary A. Levine, Jon S. Morrow and Michael C. Stankewich
- Academic press:
- Scientific Reports (year: 2021, volume: 11(1):7312, pages: 7312), Publisher: Nature Research
- Status:
- Published
- DOI:
- 10.1038/s41598-021-86470-1 – link to the publication