Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Examining phenotype of mice carrying a novel dominant-negative, spontaneous mutation of spectrin alpha II encoding gene (Spna2)

2017/25/B/NZ3/03012

Keywords:

cerebellar ataxia nonerythroid spectrin alpha chain point mutation signal transduction calmodulin lymphocyte activation

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Arkadiusz Miążek 

Number of co-investigators in the project: 3

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 784 080 PLN

Project start date (Y-m-d): 2018-02-16

Project end date (Y-m-d): 2022-02-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik ELISPOT (90 000 PLN)
  2. Kompaktowy analizator komórkowy (68 000 PLN)
  3. Mini-spektrofotometr UV/Vis (45 000 PLN)
  4. Indywidualnie wentylowane klatki dla myszy z butelkami (40 sztuk) (40 szt.) (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Age-dependent ataxia and neurodegeneration caused by an αΙΙ spectrin mutation with impaired regulation of its calpain sensitivity
    Authors:
    Arkadiusz Miazek, Michał Zalas, Joanna Skrzymowska, Bryan A. Bogin, Krzysztof Grzymajło, Tomasz Goszczynski, Zachary A. Levine, Jon S. Morrow and Michael C. Stankewich
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1):7312, strony: 7312), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-021-86470-1 - link to the publication
  2. An alpha II spectrin mutant peptide with unstable scaffold structure and increased sensitivity to calpain cleavage
    Authors:
    Joanna Skrzymowska, Michał Zalas, Krzysztof Goszczyński, Arkadiusz Miazek
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2021, tom: 581, strony: 68-73), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.021 - link to the publication

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