Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Influence of gut microbiome on induction of tumor-specific immunity

2017/25/B/NZ5/01949

Keywords:

microbiome metabolome tumor immunity

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ5_7: Human disease treatment
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Schmidt 

Number of co-investigators in the project: 8

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 708 744 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2022-01-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie TASQ - analiza sygnałów w skriningu i aplikacjach ilościowych (45 000 PLN)
  2. Oprogramowanie uzupełniające MetaboScape 2.0 do identyfikacji metabolitów w ludzkich płynach ustrojowych (20 000 PLN)
  3. Silnik do kompresora Jun-Air 2xOF1202-40M (15 000 PLN)
  4. Oprogramowanie MetaboScape 2.0 zintegrowane z systemem Compass Metabolomics (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells
    Authors:
    Pietrzak, Bernadeta; Tomela, Katarzyna; Olejnik-Schmidt, Agnieszka; Mackiewicz, Andrzej; Schmidt, Marcin
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 9254), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21239254 - link to the publication
  2. The Tumor and Host Immune Signature, and the Gut Microbiota as Predictive Biomarkers for Immune Checkpoint Inhibitor Response in Melanoma Patients
    Authors:
    Tomela, Katarzyna; Pietrzak, Bernadeta; Schmidt, Marcin; Mackiewicz, Andrzej
    Academic press:
    Life (rok: 2020, tom: 10, strony: 219), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/life10100219 - link to the publication
  3. A Clinical Outcome of the Anti-PD-1 Therapy of Melanoma in Polish Patients Is Mediated by Population-Specific Gut Microbiome Composition
    Authors:
    Pietrzak B, Tomela K, Olejnik-Schmidt A, Galus Ł, Mackiewicz J, Kaczmarek M, Mackiewicz A, Schmidt M
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 5369), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/cancers14215369 - link to the publication

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