Functional study of rare BRAF mutations on liver cancer development using CRISPR/Cas9 system
2017/25/N/NZ5/01885
Keywords
Descriptors
- NZ5_3: Patogeneza chorób człowieka
- NZ5_1: Etiologia chorób człowieka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Instytut Genetyki i Hodowli Zwierząt PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 13 – announced on 2017-03-15
- Amount awarded
- 180 000 PLN
- Project start date
- 2018-02-07
- Project end date
- 2021-08-06
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (2)
-
Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression
- Authors:
- Magdalena Śmiech, Paweł Leszczyński, Christopher Wardell, Piotr Poznański, Mariusz Pierzchała, Hiroaki Taniguchi
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 1548), Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
- Status:
- Published
- DOI:
- 10.3390/ijms23031548 – link to the publication
-
Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks
- Authors:
- Magdalena Śmiech, Paweł Leszczyński, Hidetoshi Kono, Christopher Wardell, Hiroaki Taniguchi
- Academic press:
- Genes (year: 2020, volume: 11, pages: 1–14), Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
- Status:
- Published
- DOI:
- 10.3390/genes11111342 – link to the publication
Book publications / chapters in book publications (1)
-
Cloning-Free (DNA-Free) CRISPR-Cas9-Mediated Gene Editing in Human Liver Cell Line and Its Detection
- Authors:
- Magdalena Śmiech, Paweł Leszczyński, Effi Haque, Hiroaki Taniguchi
- Book:
- CRISPR-Cas Methods (year: 2020, volume: brak, pages: 163-171), Publisher: Springer Protocols Handbooks
- Status:
- Published