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Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered modified nucleosides: ct6A, ms2ct6A, ges2U

2017/25/B/ST5/00971

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • ST5_23: Chemia organiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Politechnika Łódzka, Wydział Chemiczny

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Elżbieta Jadwiga Sochacka

Number of co-investigators in the project: 9

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 390 200 PLN
Project start date
2018-02-21
Project end date
2022-02-20
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw HPLC. Cost: 340 000 PLN
  2. pompa próżniowa. Cost: 10 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Thermodynamic and structural contributions of the 6-thioguanosine residue to helical properties of RNA

    Authors:
    Michał Gładysz, Witold Andrałojć , Tomasz Czapik , Zofia Gdaniec, Ryszard Kierzek
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 4385), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-40715-2 – link to the publication

  2. Chemical synthesis of oligoribonucleotide (ASL of tRNALys T.brucei) containing a recently discovered cyclic form of 2-methylthio-N6-threonylcarbamoyladenosine (ms2ct6A)

    Authors:
    Debiec K, Matuszewski M, Podskoczyj K, Leszczynska G, Sochacka E.
    Academic press:
    Chemistry, A European Journal (year: 2019, volume: 25, pages: 13309-13317), Publisher: Wiley – VCH
    Status:
    Published
    DOI:
    10.1002/chem.201902411 – link to the publication

  3. Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair

    Authors:
    Indrajit Deb, Łukasz Popenda, Joanna Sarzyńska, Magdalena Małgowska, Ansuman Lahiri, Zofia Gdaniec, Ryszard Kierzek
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 16278), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-52637-0 – link to the publication

  4. Efficient access to 3'-O-phosphoramidite derivatives of tRNA related N6-threonylcarbamoyladenosine (t6A) and 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)

    Authors:
    Katarzyna Debiec, Elzbieta Sochacka
    Academic press:
    RSC Advances (year: 2021, volume: 11, pages: 1992-1999), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0ra09803e – link to the publication

  5. New efficient synthesis of tRNA related adenosines bearing the hydantoin ring (ct6A, ms2ct6A) by intramolecular cyclization of N6-Boc-α-aminoacyl)adenosine derivatives-

    Authors:
    Katarzyna Frankowska, Elżbieta Sochacka
    Academic press:
    ChemBioChem (year: 2022, volume: 23, pages: e2002100655), Publisher: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/cbic.202100655 – link to the publication

  6. Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levels

    Authors:
    L. P. Sarin, S. D. Kienast, J. Leufken, R. L. Ross, A. Dziergowska, K. Debiec, E. Sochacka, P. A. Limbach,
    Academic press:
    RNA (year: 2018, volume: 24, pages: 1403-1417), Publisher: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.065482.117 – link to the publication

  7. Synthesis of nucleobase-modified RNA oligonucleotides by post-synthetic approach

    Authors:
    Karolina Bartosik, Katarzyna Debiec, Anna Czarnecka, Elzbieta Sochacka, grazyna Leszczynska
    Academic press:
    Molecules (year: 2020, volume: 25, pages: 3344), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153344 – link to the publication

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