Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Function of secondary structure of influenza A virus vRNA in ribonucleoprotein complex during viral life cycle

2017/24/C/NZ1/00219

Keywords:

secondary structure ribonucleic acid influenza virus ribonucleoprotein complex site-directed mutagenesis RNA function

Descriptors:

  • NZ1_1:
  • NZ1_4:
  • NZ1_10:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Elżbieta Lenartowicz 

Number of co-investigators in the project: 3

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 1 083 146 PLN

Project start date (Y-m-d): 2017-11-10

Project end date (Y-m-d): 2021-11-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing
    Authors:
    Dagny Lorent, Rafal Nowak, Monika Gazecka, Pawel Zmora, Elzbieta Lenartowicz Onyekaa
    Academic press:
    Open Life Sciences (rok: 2025, tom: 20, strony: 20251098), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/biol-2025-1098 - link to the publication
  2. Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides
    Authors:
    Michalak P, Soszynska-Jozwiak M, Biala E, Moss WN, Kesy J, Szutkowska B, Lenartowicz E, Kierzek R, Kierzek E
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 3801), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-40443-7 - link to the publication
  3. RNA Secondary Structure Motifs of the Influenza A Virus as Targets for siRNA-Mediated RNA Interference
    Authors:
    J. Piasecka, E. Lenartowicz, M. Soszynska-Jozwiak, B. Szutkowska, R. Kierzek, E. Kierzek
    Academic press:
    Molecular Therapy - Nucleic Acid (rok: 2020, tom: 19, strony: 627-642), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.o - link to the publication

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