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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of maternal immune activation on mitochondria function. Implication for neurodevelopmental disorders

2016/23/D/NZ4/03572

Keywords:

mitochondria Lipopolisaccharide autism

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Cieślik 

Number of co-investigators in the project: 5

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 559 800 PLN

Project start date (Y-m-d): 2017-09-12

Project end date (Y-m-d): 2021-09-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. profesjonalne oprogramowanie do komputera osobistego (GrapPad Prism, EndNote, TotalLab, CorelDraw) (7 000 PLN)
  2. Komora do czystej pracy z próbkami RNA/DNA i do przygotowywania roztworów do iniekcji (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (7)
  1. The role of maternal immune activation in the pathogenesis of autism: a review of the evidence, proposed mechanisms and implications for treatment.
    Authors:
    Zawadzka A, Cieślik M, Adamczyk A
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22(21), strony: 11516), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111516 - link to the publication
  2. Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficitsin the Adolescent Rat Offspring
    Authors:
    Cieślik M, Gąssowska-Dobrowolska M, Jęśko H, Czapski GA, Wilkaniec A, Zawadzka A, Dominiak A, Polowy R, Filipkowski RK, Boguszewski PM, Gewartowska M, Frontczak-Baniewicz M, Sun GY, Beversdorf DQ, Adamczyk A.
    Academic press:
    Int. J. Mol. Sci (rok: 2020, tom: 21, strony: 4097), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21114097 - link to the publication
  3. The synaptic dysregulation in adolescent rats exposed to maternal immune activation.
    Authors:
    Cieślik M, Gąssowska-Dobrowolska M, Zawadzka A, Frontczak-Baniewicz M, Gewartowska M, Dominiak A, Czapski GA, Adamczyk A.
    Academic press:
    Front. Mol. Neurosci. (rok: 2021, tom: 13, strony: 555290), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fnmol.2020.555290 - link to the publication
  1. Maternal immune activation leads to alterations of mitochondrial biogenesis and dynamics in offspring brain development.
    Authors:
    Cieślik M, Zawadzka A, Wilkaniec A, Adamczyk A,
    Conference:
    Virtual FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25-27 August 2021
    Status:
    Published
  2. Maternal immune activation during pregnancy alters the expression of mitochondrial dynamic markers in the brain of rat offspring.
    Authors:
    Zawadzka A, Cieślik M, Gewartowska M, Frontczak-Baniewicz M, Adamczyk A.
    Conference:
    XIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp 2019, 79, Exeley
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  3. Gestational exposure to lipopolysaccharide results in mitochondrial respiratory chain complexes alterations in the adolescent offspring.
    Authors:
    Zawadzka A, Cieślik M, Adamczyk A.
    Conference:
    23rd ESN Biennial Meeting 7th Conference on Molecular Mechanisms of Regulation in the Nervous System, Milan (rok: 2019, ), Wydawca: ESN
    Data:
    konferencja 2019-09-01-04
    Status:
    Published
  4. Alteration of mitochondrial morphology and function in juvenile rats exposed to maternal immune activation
    Authors:
    Cieślik M, Zawadzka A, Wilkaniec A, Gewartowska M, Frontczak-Baniewicz M, Beversdorf DQ, Adamczyk A.
    Conference:
    INSAR 2019 Annual Meeting, Montreal, Canada (rok: 2019, ), Wydawca: INSAR
    Data:
    konferencja 2019-05-01-04
    Status:
    Published
  5. The association between maternal immune activation and mitochondrial failure in adulthood: relevance to neurodevelopmental disorders.
    Authors:
    Cieślik M, Adamczyk A
    Conference:
    XIV International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiol Exp 2019, 79, Exeley
    Data:
    konferencja 2019-03-28-30
    Status:
    Published
  6. The role of maternal immune activation on transcriptional alteration of mitochondrial
    Authors:
    Zawadzka A., Wilkaniec A., Adamczyk A., Cieslik M.
    Conference:
    the 14th International Symposium Molecular Basis Of Pathology And Therapy In Neurological Disorders (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja 25-26.10.2018
    Status:
    Published
  7. Maternal immune activation results in long-lasting changes in mitochondrial function in the adult offspring
    Authors:
    Zawadzka A, Adamczyk A, Cieślik M
    Conference:
    8th MITOCHONDRION: in memory of Prof. L. Wojtczak, Warszawa 5.02.2020 (rok: 2020, ), Wydawca: Inst. Biol. Dośw. im. M. Nenckiego
    Data:
    konferencja 5.02.2020
    Status:
    Published

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