Zmiana języka

Projects search

Cannabidiol as potential therapeutic agent for psoriasis and its role in the stabilization of physiological level of lipid mediators.

2016/23/B/NZ7/02350

Keywords

Descriptors

  • NZ7_12: Prewencja chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Voivodeship: podlaskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Elżbieta Skrzydlewska

Number of co-investigators in the project: 18

Call

OPUS 12 – announced on 2016-09-15

Amount awarded
1 447 468 PLN
Project start date
2017-08-03
Project end date
2021-08-02
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny podajnik próbek UPLC. Cost: 112 000 PLN
  2. Pompa binarna UPLC. Cost: 187 900 PLN

Information in the final report

Publication in academic press/journals (26)

  1. Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients

    Authors:
    W.Łuczaj, I.Dobrzynska, A.Wronski, M.R.Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Int.J.Mol.Sci. (year: 2020, volume: 21, pages: 6592), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186592 – link to the publication

  2. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients

    Authors:
    E. Ambrożewicz,1 P. Wojcik,1 A. Wroński,2 W. Luczaj,1 A. Jastrząb,1 N. Zarkovic,3 E.Skrzydlewska1*
    Academic press:
    Cells (year: 2018, volume: 7(10), pages: 159), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells71001159 – link to the publication

  3. Lipidomic Analysis Reveals Specific Differences between Fibroblast and Keratinocyte Ceramide Profile of Patients with Psoriasis Vulgaris

    Authors:
    Łuczaj W., Wroński A., Domingues P., Domingues M.R., Skrzydlewska E.
    Academic press:
    Molecules (year: 2020, volume: 25, pages: Article ID 630, 14 pp), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030630 – link to the publication

  4. Analytical approaches to assess metabolic changes in psoriasis

    Authors:
    Wojciech Łuczaj, Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis 205 (2021) 11435 (year: 2021, volume: 205, pages: 46039), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2021.114359 – link to the publication

  5. Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients.

    Authors:
    Wójcik P., Gęgotek A., Wroński A., Jastrząb A., Żebrowska A., Skrzydlewska E.
    Academic press:
    J. Biochem. 2020,167,323-331; doi:10.1093/jb/mvz096 (year: 2020, volume: 167, pages: 323-331), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jb/mvz096 – link to the publication

  6. Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients

    Authors:
    P.Wójcik, M.Garley, A.Wronski, E.Jabłonska, E. Skrzydlewska
    Academic press:
    Int. J. Mol. Sci. (year: 2020, volume: 21, pages: 6795), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186795 – link to the publication

  7. The differences in proteome profile of cannabidiol treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures

    Authors:
    Gęgotek A., Atalay S., , Domingues P., Skrzydlewska
    Academic press:
    Cells (year: 2019, volume: 8, pages: 995), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8090995 – link to the publication

  8. Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

    Authors:
    A.Gęgotek, P.Domingues, A.Wroński E.Skrzydlewska
    Academic press:
    Int J Molec Sci (year: 2020, volume: 21, pages: 5363), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155363 – link to the publication

  9. Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.

    Authors:
    Wójcik P., Biernacki M., Wroński A., Łuczaj W., Waeg G., Žarković N. Skrzydlewska E.
    Academic press:
    Int. J. Molec. Sci. (year: 2019, volume: 20, pages: 4249), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20174249 – link to the publication

  10. Proteomic plasma profile of psoriatic patients

    Authors:
    Agnieszka Gęgotek, Pedro Domingues, Adam Wroński, Piotr Wojcik, Elżbieta Skrzydlewska1*
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2018, volume: 155, pages: 185-193), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.03.068 – link to the publication

  11. The proteomic profile of keratinocytes and lymphocytes in psoriatic patients

    Authors:
    Agnieszka Gęgotek1, Pedro Domingues2, Adam Wroński3, Ewa Ambrożewicz1, Elżbieta Skrzydlewska1*
    Academic press:
    Proteomic Clinical Application (year: 2019, volume: 1800119, pages: 1800119), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/prca.201800119 – link to the publication

  12. Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation.

    Authors:
    Jastrząb A., Gęgotek A., Skrzydlewska E.
    Academic press:
    Cells, (year: 2019, volume: 8, pages: 827), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8080827 – link to the publication

  13. Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients

    Authors:
    P.Karabowicz, A.Wronski, H.Ostrowska, G.Waeg, N.Zarkovic, E.Skrzydlewska
    Academic press:
    Int J Molec Sci (year: 2020, volume: 21, pages: 7608), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207608 – link to the publication

  14. UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol.

    Authors:
    Gęgotek A., Atalay S., Skrzydlewska E.
    Academic press:
    Sci.Reports 11 (2021) 20666. https://doi.org/10.1038/s41598-021-00134-8 (year: 2021, volume: 11, pages: 13, 20666), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-00134-8 – link to the publication

  15. Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol

    Authors:
    Michał Biernacki , Anna Jastrza˛b and Elz˙bieta Skrzydlewska
    Academic press:
    Antioxidants (year: 2021, volume: 10,, pages: 46038), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10081157 – link to the publication

  16. Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases

    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1, Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska 1,*
    Academic press:
    IJMS (year: 2021, volume: 22, pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020723 – link to the publication

  17. Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol

    Authors:
    W.Łuczaj, M.Rosário Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Antioxidants (year: 2020, volume: 9, pages: 1178), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121178 – link to the publication

  18. Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development

    Authors:
    Dobrzyńska I., Szachowicz-Petelska B., Wroński A., Jarocka-Karpowicz I., Skrzydlewska E.
    Academic press:
    IJMS (year: 2020, volume: 21, pages: 9129), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239129 – link to the publication

  19. Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation

    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1 , Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (year: 2021, volume: 22, pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189956 – link to the publication

  20. Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol

    Authors:
    Michał Biernacki 1 , Małgorzata Michalina Brzóska 2 , Agnieszka Markowska 1 , Małgorzata Gała˙zyn-Sidorczuk 2, Bogdan Cylwik 3 , Agnieszka G˛egotek 1 and El˙zbieta Skrzydlewska
    Academic press:
    Antioxidants (year: 2021, volume: 10, pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10060821 – link to the publication

  21. The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People

    Authors:
    Barbara Szachowicz-Petelska 1, Wojciech Łuczaj 2, Adam Wroński 3, Anna Jastrząb 2 and Izabela Dobrzyńska 1,*
    Academic press:
    Membranes (year: 2021, volume: 11, pages: 46039), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11020111 – link to the publication

  22. Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol

    Authors:
    Wojciech Łuczaj 1,* , Anna Jastrza˛b 1 , Maria do Rosário Domingues 2,3 , Pedro Domingues 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (year: 2021, volume: 22, pages: 46040), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168700 – link to the publication

  23. Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris.

    Authors:
    Jarocka-Karpowicz I., Biernacki M., Wroński A., Gęgotek A., Skrzydlewska E.:
    Academic press:
    Biomolecules 2020, 10, 3, Article ID 367, 20 pp. doi:10.3390/biom10030367. (year: 2020, volume: 10, pages: Article ID 367, 20 pp), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030367 – link to the publication

  24. Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation

    Authors:
    Anna Jastrząb,1 Iwona Jarocka-Karpowicz,1 Agnieszka Markowska,1 Adam Wroński,2 Agnieszka Gęgotek ,1 and Elżbieta Skrzydlewska
    Academic press:
    Hindawi Oxidative Medicine and Cellular Longevity (year: 2021, volume: 2021, pages: 13), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6647222 – link to the publication

  25. Cannabidiol decreases metalloproteinase activity and normalizes angiogenesis factor expression in UVB-irradiated keratinocytes from psoriatic patients

    Authors:
    Gęgotek A., Atalay S., Wroński A., Markowska A., Skrzydlewska E
    Academic press:
    Oxidative Medicine and Cellular Longevity (year: 2021, volume: 11, pages: Article ID 7624389, 11 pages), Publisher: HIndawi
    Status:
    Published
    DOI:
    10.3390/ijms22168700 – link to the publication

  26. Therapeutic application of cannabidiol on UVA and UVB irradiated ratskin. A proteomic study

    Authors:
    Sinemyiz Atalaya, Agnieszka G˛egoteka, Adam Wro´nskib, Pedro Domiguesc,El˙zbieta Skrzydlewskaa,∗
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2021, volume: 192, pages: 46031), Publisher: ELsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113656 – link to the publication

« New search

Graphic design and implementation: Jakub Piotrowski