Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Cannabidiol as potential therapeutic agent for psoriasis and its role in the stabilization of physiological level of lipid mediators.

2016/23/B/NZ7/02350

Keywords:

psoriasis cannabidiol lipid mediators

Descriptors:

  • NZ7_12:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Skrzydlewska 

Number of co-investigators in the project: 18

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 447 468 PLN

Project start date (Y-m-d): 2017-08-03

Project end date (Y-m-d): 2021-08-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pompa binarna UPLC (187 900 PLN)
  2. Automatyczny podajnik próbek UPLC (112 000 PLN)

Information in the final report

  • Publication in academic press/journals (37)
  1. Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.
    Authors:
    Wójcik P., Biernacki M., Wroński A., Łuczaj W., Waeg G., Žarković N. Skrzydlewska E.
    Academic press:
    Int. J. Molec. Sci. (rok: 2019, tom: 20, strony: 4249), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20174249 - link to the publication
  2. Oxidative Stress and Lipid Mediators Modulate Immune Cell Functions in Autoimmune Diseases
    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1, Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska 1,*
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020723 - link to the publication
  3. Proteomic plasma profile of psoriatic patients
    Authors:
    Agnieszka Gęgotek, Pedro Domingues, Adam Wroński, Piotr Wojcik, Elżbieta Skrzydlewska1*
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2018, tom: 155, strony: 185-193), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.03.068 - link to the publication
  4. Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation.
    Authors:
    Jastrząb A., Gęgotek A., Skrzydlewska E.
    Academic press:
    Cells, (rok: 2019, tom: 8, strony: 827), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8080827 - link to the publication
  5. Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation
    Authors:
    Piotr Wójcik 1 , Agnieszka G˛egotek 1 , Neven Žarkovi´c 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45676), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189956 - link to the publication
  6. Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients
    Authors:
    P.Wójcik, M.Garley, A.Wronski, E.Jabłonska, E. Skrzydlewska
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 6795), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186795 - link to the publication
  7. Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions
    Authors:
    A.Gęgotek, P.Domingues, A.Wroński E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 5363), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155363 - link to the publication
  8. UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol.
    Authors:
    Gęgotek A., Atalay S., Skrzydlewska E.
    Academic press:
    Sci.Reports 11 (2021) 20666. https://doi.org/10.1038/s41598-021-00134-8 (rok: 2021, tom: 11, strony: 13, 20666), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-00134-8 - link to the publication
  9. The differences in proteome profile of cannabidiol treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures
    Authors:
    Gęgotek A., Atalay S., , Domingues P., Skrzydlewska
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 995), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8090995 - link to the publication
  10. Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients
    Authors:
    P.Karabowicz, A.Wronski, H.Ostrowska, G.Waeg, N.Zarkovic, E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 7608), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207608 - link to the publication
  11. The proteomic profile of keratinocytes and lymphocytes in psoriatic patients
    Authors:
    Agnieszka Gęgotek1, Pedro Domingues2, Adam Wroński3, Ewa Ambrożewicz1, Elżbieta Skrzydlewska1*
    Academic press:
    Proteomic Clinical Application (rok: 2019, tom: 1800119, strony: 1800119), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/prca.201800119 - link to the publication
  12. Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients
    Authors:
    W.Łuczaj, I.Dobrzynska, A.Wronski, M.R.Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Int.J.Mol.Sci. (rok: 2020, tom: 21, strony: 6592), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186592 - link to the publication
  13. The Differential Effect of Cannabidiol on the Composition and Physicochemical Properties of Keratinocyte and Fibroblast Membranes from Psoriatic Patients and Healthy People
    Authors:
    Barbara Szachowicz-Petelska 1, Wojciech Łuczaj 2, Adam Wroński 3, Anna Jastrząb 2 and Izabela Dobrzyńska 1,*
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11020111 - link to the publication
  14. Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol
    Authors:
    Michał Biernacki 1 , Małgorzata Michalina Brzóska 2 , Agnieszka Markowska 1 , Małgorzata Gała˙zyn-Sidorczuk 2, Bogdan Cylwik 3 , Agnieszka G˛egotek 1 and El˙zbieta Skrzydlewska
    Academic press:
    Antioxidants (rok: 2021, tom: 10, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10060821 - link to the publication
  15. Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation
    Authors:
    Anna Jastrząb,1 Iwona Jarocka-Karpowicz,1 Agnieszka Markowska,1 Adam Wroński,2 Agnieszka Gęgotek ,1 and Elżbieta Skrzydlewska
    Academic press:
    Hindawi Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 2021, strony: 13), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6647222 - link to the publication
  16. Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation.
    Authors:
    Jastrząb A., Gęgotek A., Skrzydlewska E.
    Academic press:
    Cells, (rok: 2019, tom: 8, strony: 827), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8080827 - link to the publication
  17. Cannabidiol decreases metalloproteinase activity and normalizes angiogenesis factor expression in UVB-irradiated keratinocytes from psoriatic patients
    Authors:
    Gęgotek A., Atalay S., Wroński A., Markowska A., Skrzydlewska E
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 11, strony: Article ID 7624389, 11 pages), Wydawca: HIndawi
    Status:
    Published
    DOI:
    10.3390/ijms22168700 - link to the publication
  18. Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions
    Authors:
    A.Gęgotek, P.Domingues, A.Wroński E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 5363), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155363 - link to the publication
  19. Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients.
    Authors:
    Wójcik P., Gęgotek A., Wroński A., Jastrząb A., Żebrowska A., Skrzydlewska E.
    Academic press:
    J. Biochem. 2020,167,323-331; doi:10.1093/jb/mvz096 (rok: 2020, tom: 167, strony: 323-331), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jb/mvz096 - link to the publication
  20. The differences in proteome profile of cannabidiol treated skin fibroblasts following UVA or UVB irradiation in 2D and 3D cell cultures
    Authors:
    Gęgotek A., Atalay S., , Domingues P., Skrzydlewska
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 995), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8090995 - link to the publication
  21. Cannabidiol decreases metalloproteinase activity and normalizes angiogenesis factor expression in UVB-irradiated keratinocytes from psoriatic patients
    Authors:
    Gęgotek A., Atalay S., Wroński A., Markowska A., Skrzydlewska E
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 11, strony: Article ID 7624389, 11 pages), Wydawca: HIndawi
    Status:
    Published
    DOI:
    10.3390/ijms22168700 - link to the publication
  22. Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
    Authors:
    Wojciech Łuczaj 1,* , Anna Jastrza˛b 1 , Maria do Rosário Domingues 2,3 , Pedro Domingues 2 and El˙zbieta Skrzydlewska
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168700 - link to the publication
  23. Antioxidant and Anti-inflammatory Effect of Cannabidiol Contributes to the Decreased Lipid Peroxidation of Keratinocytes of Rat Skin Exposed to UV Radiation
    Authors:
    Anna Jastrząb,1 Iwona Jarocka-Karpowicz,1 Agnieszka Markowska,1 Adam Wroński,2 Agnieszka Gęgotek ,1 and Elżbieta Skrzydlewska
    Academic press:
    Hindawi Oxidative Medicine and Cellular Longevity (rok: 2021, tom: 2021, strony: 13), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6647222 - link to the publication
  24. Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis.
    Authors:
    Wójcik P., Biernacki M., Wroński A., Łuczaj W., Waeg G., Žarković N. Skrzydlewska E.
    Academic press:
    Int. J. Molec. Sci. (rok: 2019, tom: 20, strony: 4249), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20174249 - link to the publication
  25. Effect of redox imbalance on protein modifications in lymphocytes of psoriatic patients.
    Authors:
    Wójcik P., Gęgotek A., Wroński A., Jastrząb A., Żebrowska A., Skrzydlewska E.
    Academic press:
    J. Biochem. 2020,167,323-331; doi:10.1093/jb/mvz096 (rok: 2020, tom: 167, strony: 323-331), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/jb/mvz096 - link to the publication
  26. Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development
    Authors:
    Dobrzyńska I., Szachowicz-Petelska B., Wroński A., Jarocka-Karpowicz I., Skrzydlewska E.
    Academic press:
    IJMS (rok: 2020, tom: 21, strony: 9129), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239129 - link to the publication
  27. Therapeutic application of cannabidiol on UVA and UVB irradiated ratskin. A proteomic study
    Authors:
    Sinemyiz Atalaya, Agnieszka G˛egoteka, Adam Wro´nskib, Pedro Domiguesc,El˙zbieta Skrzydlewskaa,∗
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2021, tom: 192, strony: 45666), Wydawca: ELsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113656 - link to the publication
  28. Analytical approaches to assess metabolic changes in psoriasis
    Authors:
    Wojciech Łuczaj, Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis 205 (2021) 11435 (rok: 2021, tom: 205, strony: 45674), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2021.114359 - link to the publication
  29. Changes in Hepatic Phospholipid Metabolism in Rats under UV Irradiation and Topically Treated with Cannabidiol
    Authors:
    Michał Biernacki , Anna Jastrza˛b and Elz˙bieta Skrzydlewska
    Academic press:
    Antioxidants (rok: 2021, tom: 10,, strony: 45673), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10081157 - link to the publication
  30. Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris.
    Authors:
    Jarocka-Karpowicz I., Biernacki M., Wroński A., Gęgotek A., Skrzydlewska E.:
    Academic press:
    Biomolecules 2020, 10, 3, Article ID 367, 20 pp. doi:10.3390/biom10030367. (rok: 2020, tom: 10, strony: Article ID 367, 20 pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030367 - link to the publication
  31. Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris.
    Authors:
    Jarocka-Karpowicz I., Biernacki M., Wroński A., Gęgotek A., Skrzydlewska E.:
    Academic press:
    Biomolecules 2020, 10, 3, Article ID 367, 20 pp. doi:10.3390/biom10030367. (rok: 2020, tom: 10, strony: Article ID 367, 20 pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030367 - link to the publication
  32. Reduced Proteasome Activity and Enhanced Autophagy in Blood Cells of Psoriatic Patients
    Authors:
    P.Karabowicz, A.Wronski, H.Ostrowska, G.Waeg, N.Zarkovic, E.Skrzydlewska
    Academic press:
    Int J Molec Sci (rok: 2020, tom: 21, strony: 7608), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207608 - link to the publication
  33. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients
    Authors:
    E. Ambrożewicz,1 P. Wojcik,1 A. Wroński,2 W. Luczaj,1 A. Jastrząb,1 N. Zarkovic,3 E.Skrzydlewska1*
    Academic press:
    Cells (rok: 2018, tom: 7(10), strony: 159), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells71001159 - link to the publication
  34. Lipidomic Analysis Reveals Specific Differences between Fibroblast and Keratinocyte Ceramide Profile of Patients with Psoriasis Vulgaris
    Authors:
    Łuczaj W., Wroński A., Domingues P., Domingues M.R., Skrzydlewska E.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: Article ID 630, 14 pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030630 - link to the publication
  35. Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol
    Authors:
    W.Łuczaj, M.Rosário Domingues, P.Domingues, E.Skrzydlewska
    Academic press:
    Antioxidants (rok: 2020, tom: 9, strony: 1178), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121178 - link to the publication
  36. UV induced changes in proteome of rats plasma are reversed by dermally applied cannabidiol.
    Authors:
    Gęgotek A., Atalay S., Skrzydlewska E.
    Academic press:
    Sci.Reports 11 (2021) 20666. https://doi.org/10.1038/s41598-021-00134-8 (rok: 2021, tom: 11, strony: 13, 20666), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-00134-8 - link to the publication
  37. Changes in the Physicochemical Properties of Blood and Skin Cell Membranes as a Result of Psoriasis Vulgaris and Psoriatic Arthritis Development
    Authors:
    Dobrzyńska I., Szachowicz-Petelska B., Wroński A., Jarocka-Karpowicz I., Skrzydlewska E.
    Academic press:
    IJMS (rok: 2020, tom: 21, strony: 9129), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239129 - link to the publication

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